-
1
-
-
0033565880
-
In vivo activity of leflunomide: Pharmacokinetic analyses and mechanism of immunosuppression
-
Chong AS, Huang W, Liu W et al. In vivo activity of leflunomide: Pharmacokinetic analyses and mechanism of immunosuppression. Transplantation 1999; 68:100-109.
-
(1999)
Transplantation
, vol.68
, pp. 100-109
-
-
Chong, A.S.1
Huang, W.2
Liu, W.3
-
2
-
-
0026060988
-
Prevention of kidney and skin graft rejection in rats by leflunomide, a new immunomodulating agent
-
Kuchle CC, Thoenes GH, Langer KH et al. Prevention of kidney and skin graft rejection in rats by leflunomide, a new immunomodulating agent. Transplant Proc 1991; 23:1083-1086.
-
(1991)
Transplant Proc
, vol.23
, pp. 1083-1086
-
-
Kuchle, C.C.1
Thoenes, G.H.2
Langer, K.H.3
-
3
-
-
0029808510
-
In vivo mechanism of action of leflunomide: Selective inhibition of the capacity of B lymphocytes to make T-independent xenoantibodies
-
Lin Y, Waer M. In vivo mechanism of action of leflunomide: Selective inhibition of the capacity of B lymphocytes to make T-independent xenoantibodies. Transplant Proc 1996; 28:3085.
-
(1996)
Transplant Proc
, vol.28
, pp. 3085
-
-
Lin, Y.1
Waer, M.2
-
4
-
-
0031906108
-
Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment
-
Lin Y, Goebels J, Xia G et al. Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment. Nat Med 1998; 4:173-180.
-
(1998)
Nat Med
, vol.4
, pp. 173-180
-
-
Lin, Y.1
Goebels, J.2
Xia, G.3
-
5
-
-
0028354267
-
Leflunomide in experimental transplantation. Control of rejection and alloantibody production. Reversal of acute rejection, and interaction with cyclosporine
-
Williams JW, Xiao F, Foster P et al. Leflunomide in experimental transplantation. Control of rejection and alloantibody production. Reversal of acute rejection, and interaction with cyclosporine. Transplantation 1994; 57:1223-1231.
-
(1994)
Transplantation
, vol.57
, pp. 1223-1231
-
-
Williams, J.W.1
Xiao, F.2
Foster, P.3
-
6
-
-
0028846444
-
Pharmacologically induced regression of chronic transplant rejection
-
Xiao F, Chong A, Shen J et al. Pharmacologically induced regression of chronic transplant rejection. Transplantation 1995; 60:1065-1072.
-
(1995)
Transplantation
, vol.60
, pp. 1065-1072
-
-
Xiao, F.1
Chong, A.2
Shen, J.3
-
7
-
-
0029917751
-
Control and reversal of chronic xenograft rejection in hamster-to-rat cardiac transplantation
-
Xiao F, Shen J, Chong A et al. Control and reversal of chronic xenograft rejection in hamster-to-rat cardiac transplantation. Transplant Proc 1996; 28:691-692.
-
(1996)
Transplant Proc
, vol.28
, pp. 691-692
-
-
Xiao, F.1
Shen, J.2
Chong, A.3
-
8
-
-
0035862995
-
Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide
-
Knight DA, Hejmanowski AQ, Dierksheide JE et al. Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide. Transplantation 2001; 71:170-174.
-
(2001)
Transplantation
, vol.71
, pp. 170-174
-
-
Knight, D.A.1
Hejmanowski, A.Q.2
Dierksheide, J.E.3
-
9
-
-
0033610251
-
Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide
-
Waldman WJ, Knight DA, Lurain NS et al. Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide. Transplantation 1999; 68:814-825.
-
(1999)
Transplantation
, vol.68
, pp. 814-825
-
-
Waldman, W.J.1
Knight, D.A.2
Lurain, N.S.3
-
10
-
-
0343114297
-
Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide
-
Waldman WJ, Knight DA, Blinder L et al. Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide. Intervirology 1999; 42:412-418.
-
(1999)
Intervirology
, vol.42
, pp. 412-418
-
-
Waldman, W.J.1
Knight, D.A.2
Blinder, L.3
-
11
-
-
33744780534
-
Hoechst Marion Roussel. Summary of Nda 20-905. Clinical Pharmacology/Biopharmaceutics Review
-
Sponsor: Hoechst Marion Roussel. Summary of Nda 20-905. Clinical Pharmacology/Biopharmaceutics Review 1998; 31-33.
-
(1998)
, pp. 31-33
-
-
Sponsor1
-
12
-
-
0037083864
-
Experiences with leflunomide in solid organ transplantation
-
Williams JW, Mital D, Chong A et al. Experiences with leflunomide in solid organ transplantation. Transplantation 2002; 73:358-366.
-
(2002)
Transplantation
, vol.73
, pp. 358-366
-
-
Williams, J.W.1
Mital, D.2
Chong, A.3
-
13
-
-
0031179645
-
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
-
Elder RT, Xu X, Williams JW et al. The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. J Immunol 1997; 159:22-27.
-
(1997)
J Immunol
, vol.159
, pp. 22-27
-
-
Elder, R.T.1
Xu, X.2
Williams, J.W.3
-
14
-
-
0031785254
-
Alpha-cyano-beta-hydroxy-beta-methyl-N-[4- (Trifluoromethoxy)phenyl] propenamide: An inhibitor of the epidermal growth factor receptor tyrosine kinase with potent cytotoxic activity against breast cancer cells
-
Ghosh S, Zheng Y, Jun X et al. Alpha-cyano-beta-hydroxy-beta-methyl-N-[4- (Trifluoromethoxy)phenyl] propenamide: An inhibitor of the epidermal growth factor receptor tyrosine kinase with potent cytotoxic activity against breast cancer cells. Clin Cancer Res 1998; 4:2657-2668.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 2657-2668
-
-
Ghosh, S.1
Zheng, Y.2
Jun, X.3
-
15
-
-
0033515450
-
Rational design and synthesis of a novel anti-leukemic agent targeting bruton's tyrosine kinase (Btk), Lfm-A13 [Alpha-Cyano-Beta-Hydroxy-Beta-Methyl-N-(2, 5-Dibromophenyl)propenamide]
-
Mahajan S, Ghosh S, Sudbeck EA et al. Rational design and synthesis of a novel anti-leukemic agent targeting bruton's tyrosine kinase (Btk), Lfm-A13 [Alpha-Cyano-Beta-Hydroxy-Beta-Methyl-N-(2, 5-Dibromophenyl)propenamide]. J Biol Chem 1999; 274:9587-9599.
-
(1999)
J Biol Chem
, vol.274
, pp. 9587-9599
-
-
Mahajan, S.1
Ghosh, S.2
Sudbeck, E.A.3
-
16
-
-
0027501428
-
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide
-
Mattar T, Kochhar K, Bartlett R et al. Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. Febs Lett 1993; 334:161-164.
-
(1993)
Febs Lett
, vol.334
, pp. 161-164
-
-
Mattar, T.1
Kochhar, K.2
Bartlett, R.3
-
17
-
-
0030811256
-
Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(Trifluoromethyl)-Phenyl]5-Methylisoxazole-4-Carboxamide
-
Shawver LK, Schwartz DP, Mann E et al. Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(Trifluoromethyl)-Phenyl]5-Methylisoxazole-4-Carboxamide. Clin Cancer Res 1997; 3:1167-1177.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 1167-1177
-
-
Shawver, L.K.1
Schwartz, D.P.2
Mann, E.3
-
18
-
-
0032519992
-
Inhibition of Jak3 and Stat6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in Igg1 production
-
Siemasko K, Chong AS, Jack HM et al. Inhibition of Jak3 and Stat6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in Igg1 production. J Immunol 1998; 160:1581-1588.
-
(1998)
J Immunol
, vol.160
, pp. 1581-1588
-
-
Siemasko, K.1
Chong, A.S.2
Jack, H.M.3
-
19
-
-
0029052321
-
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
-
Xu X, Williams JW, Bremer EG et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem 1995; 270:12398-12403.
-
(1995)
J Biol Chem
, vol.270
, pp. 12398-12403
-
-
Xu, X.1
Williams, J.W.2
Bremer, E.G.3
-
20
-
-
0031180972
-
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in Mrl/Mpj-Lpr/Lpr mice
-
Xu X, Blinder L, Shen J et al. In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in Mrl/Mpj-Lpr/Lpr mice. J Immunol 1997; 159:167-174.
-
(1997)
J Immunol
, vol.159
, pp. 167-174
-
-
Xu, X.1
Blinder, L.2
Shen, J.3
-
21
-
-
0032845287
-
In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: Mechanisms of action
-
Xu X, Shen J, Mall JW et al. In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: Mechanisms of action. Biochem Pharmacol 1999; 58:1405-1413.
-
(1999)
Biochem Pharmacol
, vol.58
, pp. 1405-1413
-
-
Xu, X.1
Shen, J.2
Mall, J.W.3
-
23
-
-
0032532194
-
Fk506 treatment in combination with leflunomide in hamster-to-rat heart and liver Xenograft transplantation
-
Sankary HN, Yin DP, Chong AS et al. Fk506 treatment in combination with leflunomide in hamster-to-rat heart and liver Xenograft transplantation. Transplantation 1998; 66:832-837.
-
(1998)
Transplantation
, vol.66
, pp. 832-837
-
-
Sankary, H.N.1
Yin, D.P.2
Chong, A.S.3
-
24
-
-
0029591467
-
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
-
Cherwinski HM, Cohn RG, Cheung P et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 1995; 275:1043-1049.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1043-1049
-
-
Cherwinski, H.M.1
Cohn, R.G.2
Cheung, P.3
-
25
-
-
0030032806
-
The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase
-
Davis JP, Cain GA, Pitts WJ et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 1996; 35:1270-1273.
-
(1996)
Biochemistry
, vol.35
, pp. 1270-1273
-
-
Davis, J.P.1
Cain, G.A.2
Pitts, W.J.3
-
26
-
-
0344653661
-
Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives
-
Knecht W, Loffler M. Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives. Biochem Pharmacol 1998; 56:1259-1264.
-
(1998)
Biochem Pharmacol
, vol.56
, pp. 1259-1264
-
-
Knecht, W.1
Loffler, M.2
-
27
-
-
0029127555
-
Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound
-
Williamson RA, Yea CM, Robson PA et al. Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J Biol Chem 1995; 270:22467-22472.
-
(1995)
J Biol Chem
, vol.270
, pp. 22467-22472
-
-
Williamson, R.A.1
Yea, C.M.2
Robson, P.A.3
-
28
-
-
0033557695
-
Immunosuppressive leflunomide metabolite (A77 1726) blocks tnf-dependent nuclear factor-kappa B activation and gene expression
-
Manna SK, Aggarwal BB. Immunosuppressive leflunomide metabolite (A77 1726) blocks tnf-dependent nuclear factor-kappa B activation and gene expression. J Immunol 1999; 162:2095-2102.
-
(1999)
J Immunol
, vol.162
, pp. 2095-2102
-
-
Manna, S.K.1
Aggarwal, B.B.2
-
29
-
-
0029144186
-
Leflunomide interferes with pyrimidine nucleotide biosynthesis
-
Cherwinski HM, Byars N, Ballaron SJ et al. Leflunomide interferes with pyrimidine nucleotide biosynthesis. Inflamm Res 1995; 44:317-322.
-
(1995)
Inflamm Res
, vol.44
, pp. 317-322
-
-
Cherwinski, H.M.1
Byars, N.2
Ballaron, S.J.3
-
30
-
-
12644249109
-
In vitro and in vivo effects of leflunomide, brequinar, and cyclosporine on pyrimidine biosynthesis
-
Silva Jr HT, Cao W, Shorthouse RA et al. In vitro and in vivo effects of leflunomide, brequinar, and cyclosporine on pyrimidine biosynthesis. Transplant Proc 1997; 29:1292-1293.
-
(1997)
Transplant Proc
, vol.29
, pp. 1292-1293
-
-
Silva Jr, H.T.1
Cao, W.2
Shorthouse, R.A.3
-
31
-
-
0034098326
-
Immunosuppressive drugs: The first 50 years and a glance forward
-
Allison AC. Immunosuppressive drugs: The first 50 years and a glance forward. Immunopharmacology 2000; 47:63-83.
-
(2000)
Immunopharmacology
, vol.47
, pp. 63-83
-
-
Allison, A.C.1
-
32
-
-
0028895216
-
-
Nair RV, Cao W, Morris RE. Inhibition of smooth muscle cell proliferation in vitro by leflunomide. A new immunosuppressant, is antagonized by uridine Immunol. Lett 1995; 47:171-174.
-
Nair RV, Cao W, Morris RE. Inhibition of smooth muscle cell proliferation in vitro by leflunomide. A new immunosuppressant, is antagonized by uridine Immunol. Lett 1995; 47:171-174.
-
-
-
-
33
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999; 79:1283-1316.
-
(1999)
Physiol Rev
, vol.79
, pp. 1283-1316
-
-
Heldin, C.H.1
Westermark, B.2
-
34
-
-
0025277164
-
Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1
-
Border WA, Okuda S, Languino LR et al. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature 1990; 346:371-374.
-
(1990)
Nature
, vol.346
, pp. 371-374
-
-
Border, W.A.1
Okuda, S.2
Languino, L.R.3
-
35
-
-
0028968622
-
Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
-
Buchdunger E, Zimmermann J, Mett H et al. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci USA 1995; 92:2558-2562.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2558-2562
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
-
36
-
-
0026603130
-
Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor
-
Doi T, Vlassara H, Kirstein M et al. Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor. Proc Nad Acad Sci USA 1992; 89:2873-2877.
-
(1992)
Proc Nad Acad Sci USA
, vol.89
, pp. 2873-2877
-
-
Doi, T.1
Vlassara, H.2
Kirstein, M.3
-
37
-
-
0027136163
-
Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats
-
Floege J, Eng E, Young BA et al. Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats. J Clin Invest 1993; 92:2952-2962.
-
(1993)
J Clin Invest
, vol.92
, pp. 2952-2962
-
-
Floege, J.1
Eng, E.2
Young, B.A.3
-
38
-
-
0029125438
-
Multiple roles for platelet-derived growth factor in renal disease
-
Floege J, Johnson RJ. Multiple roles for platelet-derived growth factor in renal disease. Miner Electrolyte Metab 1995; 21:271-282.
-
(1995)
Miner Electrolyte Metab
, vol.21
, pp. 271-282
-
-
Floege, J.1
Johnson, R.J.2
-
39
-
-
0032896149
-
Novel approach to specific growth factor inhibition in vivo: Antagonism of platelet-derived growth factor in glomerulonephritis by aptamers
-
Floege J, Ostendorf T, Janssen U et al. Novel approach to specific growth factor inhibition in vivo: Antagonism of platelet-derived growth factor in glomerulonephritis by aptamers. Am J Pathol 1999; 154:169-179.
-
(1999)
Am J Pathol
, vol.154
, pp. 169-179
-
-
Floege, J.1
Ostendorf, T.2
Janssen, U.3
-
40
-
-
0035074267
-
Pdgf signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis
-
Gilbert RE, Kelly DJ, Mckay T et al. Pdgf signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. Kidney Int 2001; 59:1324-1332.
-
(2001)
Kidney Int
, vol.59
, pp. 1324-1332
-
-
Gilbert, R.E.1
Kelly, D.J.2
Mckay, T.3
-
41
-
-
0026000337
-
Platelet-derived growth factor (Pdgf) and Pdgf receptor are induced in mesangial proliferative nephritis in the rat
-
Iida H, Seifert R, Alpers CE et al. Platelet-derived growth factor (Pdgf) and Pdgf receptor are induced in mesangial proliferative nephritis in the rat. Proc Natl Acad Sci USA 1991; 88:6560-6564.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 6560-6564
-
-
Iida, H.1
Seifert, R.2
Alpers, C.E.3
-
42
-
-
0027138877
-
Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney
-
Isaka Y, Fujiwara Y, Ueda N et al. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney. J Clin Invest 1993; 92:2597-2601.
-
(1993)
J Clin Invest
, vol.92
, pp. 2597-2601
-
-
Isaka, Y.1
Fujiwara, Y.2
Ueda, N.3
-
43
-
-
0029905441
-
Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
-
Isaka Y, Brees DK, Ikegaya K et al. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 1996; 2:418-423.
-
(1996)
Nat Med
, vol.2
, pp. 418-423
-
-
Isaka, Y.1
Brees, D.K.2
Ikegaya, K.3
-
44
-
-
0026562550
-
Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor
-
Johnson RJ, Raines EW, Floege J et al. Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 1992; 175:1413-1416.
-
(1992)
J Exp Med
, vol.175
, pp. 1413-1416
-
-
Johnson, R.J.1
Raines, E.W.2
Floege, J.3
-
45
-
-
0035034653
-
Specific antagonism of Pdgf prevents renal scarring in experimental glomerulonephritis
-
Ostendorf T, Kunter U, Grone HJ et al. Specific antagonism of Pdgf prevents renal scarring in experimental glomerulonephritis. J Am Soc Nephrol 2001; 12:909-918.
-
(2001)
J Am Soc Nephrol
, vol.12
, pp. 909-918
-
-
Ostendorf, T.1
Kunter, U.2
Grone, H.J.3
-
46
-
-
0036189252
-
The effects of platelet-derived growth factor antagonism in experimental glomerulonephritis are independent of the transforming growth factor-beta system
-
Ostendorf T, Kunter U, Van Roeyen C et al. The effects of platelet-derived growth factor antagonism in experimental glomerulonephritis are independent of the transforming growth factor-beta system. J Am Soc Nephrol 2002; 13:658-667.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 658-667
-
-
Ostendorf, T.1
Kunter, U.2
Van Roeyen, C.3
-
47
-
-
0029869237
-
Platelet-derived growth factor-bb induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis
-
Tang WW, Ulich TR, Lacey DI et al. Platelet-derived growth factor-bb induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Am J Pathol 1996; 148:1169-1180.
-
(1996)
Am J Pathol
, vol.148
, pp. 1169-1180
-
-
Tang, W.W.1
Ulich, T.R.2
Lacey, D.I.3
-
48
-
-
0028980435
-
Pdgf and Tgf-beta mediate collagen production by mesangial cells exposed to advanced glycosylation end products
-
Throckmorton DC, Brogden AP, Min B et al. Pdgf and Tgf-beta mediate collagen production by mesangial cells exposed to advanced glycosylation end products. Kidney Int 1995; 48:111-117.
-
(1995)
Kidney Int
, vol.48
, pp. 111-117
-
-
Throckmorton, D.C.1
Brogden, A.P.2
Min, B.3
-
49
-
-
0032212098
-
Beneficial effects of a novel inhibitor of platelet-derived growth factor Receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis
-
Yagi M, Kato S, Kobayashi Y et al. Beneficial effects of a novel inhibitor of platelet-derived growth factor Receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis. Gen Pharmacol 1998; 31:765-773.
-
(1998)
Gen Pharmacol
, vol.31
, pp. 765-773
-
-
Yagi, M.1
Kato, S.2
Kobayashi, Y.3
-
50
-
-
0029830377
-
Leflunomide, A novel immunomodulating drug. Inhibits homotypic adhesion of mononuclear cells in rheumatoid arthritis
-
Dimitrijevic M, Bartlett RR. Leflunomide, A novel immunomodulating drug. Inhibits homotypic adhesion of mononuclear cells in rheumatoid arthritis. Transplant Proc 1996; 28:3086-3087.
-
(1996)
Transplant Proc
, vol.28
, pp. 3086-3087
-
-
Dimitrijevic, M.1
Bartlett, R.R.2
-
51
-
-
0033947789
-
Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: Findings in a prospective, randomized, double-blind clinical trial in fifteen patients
-
Kraan MC, De Koster BM, Elferink JG et al. Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: Findings in a prospective, randomized, double-blind clinical trial in fifteen patients. Arthritis Rheum 2000; 43:1488-1495.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 1488-1495
-
-
Kraan, M.C.1
De Koster, B.M.2
Elferink, J.G.3
-
52
-
-
0036387286
-
Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast I1-6 production by distinct mechanisms
-
Miljkovic D, Samardzic T, Drakulic D et al. Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast I1-6 production by distinct mechanisms. Cytokine 2002; 19:181-186.
-
(2002)
Cytokine
, vol.19
, pp. 181-186
-
-
Miljkovic, D.1
Samardzic, T.2
Drakulic, D.3
-
53
-
-
0029913383
-
Regulation of B cell function by the immunosuppressive agent leflunomide
-
Siemasko KF, Chong AS, Williams JW et al. Regulation of B cell function by the immunosuppressive agent leflunomide. Transplantation 1996; 61:635-642.
-
(1996)
Transplantation
, vol.61
, pp. 635-642
-
-
Siemasko, K.F.1
Chong, A.S.2
Williams, J.W.3
-
54
-
-
0033058631
-
Oral administration of leflunomide (Hwa486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model
-
Mizushima Y, Amano Y, Kitagawa H et al. Oral administration of leflunomide (Hwa486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model. J Pharmacol Exp Ther 1999; 288:849-857.
-
(1999)
J Pharmacol Exp Ther
, vol.288
, pp. 849-857
-
-
Mizushima, Y.1
Amano, Y.2
Kitagawa, H.3
-
55
-
-
0037238591
-
The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes
-
Burger D, Begue-Pastor N, Benavent S et al. The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes. Rheumatology (Oxford) 2003; 42:89-96.
-
(2003)
Rheumatology (Oxford)
, vol.42
, pp. 89-96
-
-
Burger, D.1
Begue-Pastor, N.2
Benavent, S.3
-
56
-
-
0035959338
-
Leflunomide-mediated suppression of antiviral antibody and T cell responses: Differential restoration by uridine
-
Pinschewer DD, Ochsenbein AF, Fehr T et al. Leflunomide-mediated suppression of antiviral antibody and T cell responses: Differential restoration by uridine. Transplantation 2001; 72:712-719.
-
(2001)
Transplantation
, vol.72
, pp. 712-719
-
-
Pinschewer, D.D.1
Ochsenbein, A.F.2
Fehr, T.3
-
57
-
-
0035890446
-
Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide
-
Waldman WJ, Bickerstaff A, Gordillo G et al. Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide. Transplantation 2001; 72:1578-1582.
-
(2001)
Transplantation
, vol.72
, pp. 1578-1582
-
-
Waldman, W.J.1
Bickerstaff, A.2
Gordillo, G.3
-
58
-
-
0028856439
-
Immunosuppressive effects of leflunomide in experimental chronic vascular rejection
-
Swan SK, Crary GS, Guijarro C et al. Immunosuppressive effects of leflunomide in experimental chronic vascular rejection. Transplantation 1995; 60:887-890.
-
(1995)
Transplantation
, vol.60
, pp. 887-890
-
-
Swan, S.K.1
Crary, G.S.2
Guijarro, C.3
-
59
-
-
0028846444
-
Pharmacologically induced regression of chronic transplant rejection
-
Xiao F, Chong A, Shen J et al. Pharmacologically induced regression of chronic transplant rejection. Transplantation 1995; 60:1065-72.
-
(1995)
Transplantation
, vol.60
, pp. 1065-1072
-
-
Xiao, F.1
Chong, A.2
Shen, J.3
-
60
-
-
0028317333
-
Newer immunosuppressive drugs in concordant Xenografting-transplantation of hamster heart to rat
-
Kemp E, Dieperink H, Jensen J et al. Newer immunosuppressive drugs in concordant Xenografting-transplantation of hamster heart to rat. Xenotransplantation 1994; 1:102-108.
-
(1994)
Xenotransplantation
, vol.1
, pp. 102-108
-
-
Kemp, E.1
Dieperink, H.2
Jensen, J.3
-
61
-
-
0042467489
-
Leflunomide analogue Fk778 is vasculoprotective independent of its immunosuppressive effect: Potential applications for restenosis and chronic rejection
-
Savikko J, Von Willebrand E, Hayry P. Leflunomide analogue Fk778 is vasculoprotective independent of its immunosuppressive effect: Potential applications for restenosis and chronic rejection. Transplantation 2003; 76:455-458.
-
(2003)
Transplantation
, vol.76
, pp. 455-458
-
-
Savikko, J.1
Von Willebrand, E.2
Hayry, P.3
-
62
-
-
0036819728
-
Prospective, Pilot, Open-label, Short-term study of conversion to leflunomide reverses chronic renal allograft dysfunction
-
Hardinger KL, Wang CD, Schnitzler MA et al. Prospective, Pilot, Open-label, Short-term study of conversion to leflunomide reverses chronic renal allograft dysfunction. Am J Transplant 2002; 2:867-871.
-
(2002)
Am J Transplant
, vol.2
, pp. 867-871
-
-
Hardinger, K.L.1
Wang, C.D.2
Schnitzler, M.A.3
-
63
-
-
19944382834
-
Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection
-
Avery RK, Bolwell BJ, Yen-Lieberman B et al. Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection. Bone Marrow Transplant 2004.
-
(2004)
Bone Marrow Transplant
-
-
Avery, R.K.1
Bolwell, B.J.2
Yen-Lieberman, B.3
-
64
-
-
2442717552
-
Leflunomide therapy for cytomegalovirus disease in renal allograft recepients
-
John GT, Manivannan J, Chandy S et al. Leflunomide therapy for cytomegalovirus disease in renal allograft recepients. Transplantation 2004; 77:1460-1461.
-
(2004)
Transplantation
, vol.77
, pp. 1460-1461
-
-
John, G.T.1
Manivannan, J.2
Chandy, S.3
-
65
-
-
33744819810
-
The use of Leflunomide in vitally infected transplant patients
-
Josephson MA, Kadambi PV, Javaid B et al. The use of Leflunomide in vitally infected transplant patients. J Am Soc Nephrol 2004; 15:523a.
-
(2004)
J Am Soc Nephrol
, vol.15
-
-
Josephson, M.A.1
Kadambi, P.V.2
Javaid, B.3
-
66
-
-
0032910625
-
The Banff 97 working classification of renal allograft pathology
-
Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55:713-723.
-
(1999)
Kidney Int
, vol.55
, pp. 713-723
-
-
Racusen, L.C.1
Solez, K.2
Colvin, R.B.3
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