-
1
-
-
0025980747
-
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection
-
Bartlett RR, Dimitrijevic M, Mattar T, Zielinski T, Germann T, Rüde E, Thoenes GH, Küchle CCA, Schorlemmer HU, Bremer E, Finnegan A and Schleyerbach R (1991) Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection. Agents Actions 32:10-21.
-
(1991)
Agents Actions
, vol.32
, pp. 10-21
-
-
Bartlett, R.R.1
Dimitrijevic, M.2
Mattar, T.3
Zielinski, T.4
Germann, T.5
Rüde, E.6
Thoenes, G.H.7
Küchle, C.C.A.8
Schorlemmer, H.U.9
Bremer, E.10
Finnegan, A.11
Schleyerbach, R.12
-
2
-
-
0002188965
-
Leflunomide (HWA 486): A novel immunorestoring drug
-
(Lewis AJ, Doherty NS and Ackerman NR eds) Elsevier Science Publishing, New York
-
Bartlett RR, Mattar T, Weithmann U, Anagnostopoulos H, Popovic S and Schleyerbach R (1989) Leflunomide (HWA 486): A novel immunorestoring drug, in Therapeutic Approaches to Inflammatory Diseases (Lewis AJ, Doherty NS and Ackerman NR eds) pp 215-228, Elsevier Science Publishing, New York.
-
(1989)
Therapeutic Approaches to Inflammatory Diseases
, pp. 215-228
-
-
Bartlett, R.R.1
Mattar, T.2
Weithmann, U.3
Anagnostopoulos, H.4
Popovic, S.5
Schleyerbach, R.6
-
3
-
-
0024250889
-
Development of autoimmunity in MRL/lpr mice and the effects of drugs on this murine disease
-
Bartlett RR, Popovic S and Raiss RX (1988) Development of autoimmunity in MRL/lpr mice and the effects of drugs on this murine disease. Scand J Rheumatol Suppl 75:290-299.
-
(1988)
Scand J Rheumatol Suppl
, vol.75
, pp. 290-299
-
-
Bartlett, R.R.1
Popovic, S.2
Raiss, R.X.3
-
4
-
-
0021957656
-
Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity-I. Disease modifying action on adjuvant arthritis of the rat
-
Bartlett RR and Schleyerbach R (1985) Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity-I. Disease modifying action on adjuvant arthritis of the rat. Int J Immunopharmacol 7:7-18.
-
(1985)
Int J Immunopharmacol
, vol.7
, pp. 7-18
-
-
Bartlett, R.R.1
Schleyerbach, R.2
-
5
-
-
0030064262
-
Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro
-
Chong ASF, Rezai K, Gebel HM, Finnegan A, Foster P, Xu XL and Williams JW (1996) Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro. Transplantation 61:140-145.
-
(1996)
Transplantation
, vol.61
, pp. 140-145
-
-
Chong, A.S.F.1
Rezai, K.2
Gebel, H.M.3
Finnegan, A.4
Foster, P.5
Xu, X.L.6
Williams, J.W.7
-
6
-
-
0027452977
-
Disruption of the murine IL-4 gene blocks Th2 cytokine responses
-
Kopf M, Gros GL, Bachmann M, Lamers MC, Bluethmann H and Köhler G (1993) Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature (Lond) 362:245-248.
-
(1993)
Nature (Lond)
, vol.362
, pp. 245-248
-
-
Kopf, M.1
Gros, G.L.2
Bachmann, M.3
Lamers, M.C.4
Bluethmann, H.5
Köhler, G.6
-
7
-
-
0026060988
-
Prevention of kidney and skin graft rejection in rats by leflunomide, a new immunomodulating agent
-
Küchle CCA, Thoenes GH, Langer KH, Schorlemmer HU, Bartlett RR and Schleyerbach R (1991) Prevention of kidney and skin graft rejection in rats by leflunomide, a new immunomodulating agent. Transplant Proc 23:1083-1086.
-
(1991)
Transplant Proc
, vol.23
, pp. 1083-1086
-
-
Küchle, C.C.A.1
Thoenes, G.H.2
Langer, K.H.3
Schorlemmer, H.U.4
Bartlett, R.R.5
Schleyerbach, R.6
-
8
-
-
0027501428
-
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide
-
Mattar T, Kochhar K, Bartlett R, Bremer EG and Finnegan A (1993) Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. FEBS Lett 334:161-164.
-
(1993)
FEBS Lett
, vol.334
, pp. 161-164
-
-
Mattar, T.1
Kochhar, K.2
Bartlett, R.3
Bremer, E.G.4
Finnegan, A.5
-
9
-
-
0028792355
-
Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study
-
Mladenovic V, Domljan Z, Rozman B, Jajic I, Mihajlovic D, Dordevic J, Popovic M, Dimitrijevic M, Zivkovic M, Campion G, Musikic P, Löw-Friedrich I, Oed C, Seifert H and Strand V (1995) Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study. Arthritis & Rheum 38:1595-1603.
-
(1995)
Arthritis & Rheum
, vol.38
, pp. 1595-1603
-
-
Mladenovic, V.1
Domljan, Z.2
Rozman, B.3
Jajic, I.4
Mihajlovic, D.5
Dordevic, J.6
Popovic, M.7
Dimitrijevic, M.8
Zivkovic, M.9
Campion, G.10
Musikic, P.11
Löw-Friedrich, I.12
Oed, C.13
Seifert, H.14
Strand, V.15
-
10
-
-
0028358709
-
Prevention of the acute graft-versus-host disease (GVHD) in rats by the immunomodulating drug leflunomide
-
Mrowka C, Thoenes GH, Langer KH and Bartlett RR (1994) Prevention of the acute graft-versus-host disease (GVHD) in rats by the immunomodulating drug leflunomide. Ann Hematol 68:195-199.
-
(1994)
Ann Hematol
, vol.68
, pp. 195-199
-
-
Mrowka, C.1
Thoenes, G.H.2
Langer, K.H.3
Bartlett, R.R.4
-
11
-
-
0023554171
-
The use of the murine chronic graft Vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery
-
Popovic S and Bartlett RR (1987) The use of the murine chronic graft Vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery. Agents Actions 21:284-286.
-
(1987)
Agents Actions
, vol.21
, pp. 284-286
-
-
Popovic, S.1
Bartlett, R.R.2
-
12
-
-
0029743653
-
Ganglioside GM3 inhibition of EGF receptor mediated signal transduction
-
Rebbaa A, Hurh J, Yamamoto H, Kersey DS and Bremer EG (1996) Ganglioside GM3 inhibition of EGF receptor mediated signal transduction. Glycobiology 6:399-406.
-
(1996)
Glycobiology
, vol.6
, pp. 399-406
-
-
Rebbaa, A.1
Hurh, J.2
Yamamoto, H.3
Kersey, D.S.4
Bremer, E.G.5
-
13
-
-
0028124203
-
Therapeutic activity of leflunomide in acute and chronic relapsing experimental allergic encephalomyelitis
-
Schorlemmer HU and Bartlett RR (1994) Therapeutic activity of leflunomide in acute and chronic relapsing experimental allergic encephalomyelitis. Agents Actions 41:C271-C273.
-
(1994)
Agents Actions
, vol.41
-
-
Schorlemmer, H.U.1
Bartlett, R.R.2
-
14
-
-
0027536435
-
Prolongation of allogeneic transplanted skin grafts and induction of tolerance by leflunomide, a new immunosuppressive isoxazol derivative
-
Schorlemmer HU, Seiler FR and Bartlett RR (1993) Prolongation of allogeneic transplanted skin grafts and induction of tolerance by leflunomide, a new immunosuppressive isoxazol derivative. Transplant Proc 25:763-767.
-
(1993)
Transplant Proc
, vol.25
, pp. 763-767
-
-
Schorlemmer, H.U.1
Seiler, F.R.2
Bartlett, R.R.3
-
15
-
-
0029913383
-
Regulation of B cell function by the immunosuppressive agent leflunomide
-
Siemasko KF, Chong ASF, Williams JW, Bremer EG and Finnegan A (1996) Regulation of B cell function by the immunosuppressive agent leflunomide. Transplantation 61:635-642.
-
(1996)
Transplantation
, vol.61
, pp. 635-642
-
-
Siemasko, K.F.1
Chong, A.S.F.2
Williams, J.W.3
Bremer, E.G.4
Finnegan, A.5
-
16
-
-
0029807651
-
Single- and multiple-dose pharmacokinetics and pharmacodynamics of leflunomide's active metabolite A77 1726 in normal Lewis rats
-
Silva HT, Shorthouse R and Morris RE (1996) Single- and multiple-dose pharmacokinetics and pharmacodynamics of leflunomide's active metabolite A77 1726 in normal Lewis rats. Transplant Proc 28:3092-3094.
-
(1996)
Transplant Proc
, vol.28
, pp. 3092-3094
-
-
Silva, H.T.1
Shorthouse, R.2
Morris, R.E.3
-
17
-
-
0029134647
-
Protective effect of leflunomide on the natural course of Leishmania major-induced disease in genetically susceptible BALB/c mice
-
Solbach W, Asmuß PA, Zimmermann S, Humborg C and Röllinghoff M (1995) Protective effect of leflunomide on the natural course of Leishmania major-induced disease in genetically susceptible BALB/c mice. Int J Immunopharmacol 17:481-488.
-
(1995)
Int J Immunopharmacol
, vol.17
, pp. 481-488
-
-
Solbach, W.1
Asmuß, P.A.2
Zimmermann, S.3
Humborg, C.4
Röllinghoff, M.5
-
18
-
-
0024787777
-
Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats
-
Thoenes GH, Sitter T, Langer KH, Bartlett RR and Schleyerbach R (1989) Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats. Int J Immunopharmacol 11:921-929.
-
(1989)
Int J Immunopharmacol
, vol.11
, pp. 921-929
-
-
Thoenes, G.H.1
Sitter, T.2
Langer, K.H.3
Bartlett, R.R.4
Schleyerbach, R.5
-
19
-
-
0029127555
-
Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound
-
Williamson RA, Yea CM, Robson PA, Curnock AP, Gadher S, Hambleton AB, Woodward K, Bruneau JM, Hambleton P, Moss D, Thomson TA, Spinella-Jaegle S, Morand P, Courtin O, Sautés C, Westwood R, Hercend T, Kuo EA and Ruuth E (1995) Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J Biol Chem 270:22467-22472.
-
(1995)
J Biol Chem
, vol.270
, pp. 22467-22472
-
-
Williamson, R.A.1
Yea, C.M.2
Robson, P.A.3
Curnock, A.P.4
Gadher, S.5
Hambleton, A.B.6
Woodward, K.7
Bruneau, J.M.8
Hambleton, P.9
Moss, D.10
Thomson, T.A.11
Spinella-Jaegle, S.12
Morand, P.13
Courtin, O.14
Sautés, C.15
Westwood, R.16
Hercend, T.17
Kuo, E.A.18
Ruuth, E.19
-
20
-
-
0029052321
-
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
-
Xu X, Williams JW, Bremer EG, Finnegan A and Chong AS-F (1995) Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem 270:12398-12403
-
(1995)
J Biol Chem
, vol.270
, pp. 12398-12403
-
-
Xu, X.1
Williams, J.W.2
Bremer, E.G.3
Finnegan, A.4
Chong, A.S.-F.5
-
21
-
-
0030014489
-
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726: Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation
-
Xu X, Williams JW, Gong H, Finnegan A and Chong AS-F (1996) Two activities of the immunosuppressive metabolite of leflunomide, A77 1726: Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation. Biochem Pharmacol 52:527-534.
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 527-534
-
-
Xu, X.1
Williams, J.W.2
Gong, H.3
Finnegan, A.4
Chong, A.S.-F.5
-
22
-
-
0029098762
-
Leflunomide, a reversible inhibitor of pyrimidine biosynthesis?
-
Zielinski T, Zeitter D, Müllner S and Bartlett RR (1995) Leflunomide, a reversible inhibitor of pyrimidine biosynthesis? Inflamm Res 44(Suppl 2):S207-S208.
-
(1995)
Inflamm Res
, vol.44
, Issue.SUPPL. 2
-
-
Zielinski, T.1
Zeitter, D.2
Müllner, S.3
Bartlett, R.R.4
|