FK506 treatment in combination with leflunomide in hamster-to-rat heart and liver xenograft transplantation

Transplantation

Volumn 66, Issue 7, 1998, Pages 832-837

  Sankary, Howard N ^a   Yin, Deng Ping ^a   Chong, Anita S F ^a   Ma, Lian Li ^a   Blinder, Leonard ^a   Shen, Ji Kun ^a   Foster, Preston ^a   Williams, James W ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERIMMUNE GLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEFLUNOMIDE; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNE RESPONSE; INTRAMUSCULAR DRUG ADMINISTRATION; LIVER TRANSPLANTATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SERUM; SYRIAN HAMSTER; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES; ANTIBODY FORMATION; CRICETINAE; DRUG COMBINATIONS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNE SERA; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES; LIVER TRANSPLANTATION; MALE; MESOCRICETUS; RATS; TACROLIMUS; TISSUE DONORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0032532194     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199810150-00004     Document Type: Article

References (29)

1. Sigal NH, Dumont FJ. Cyclosporin A, FK506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu Rev Immunol 1992; 10: 519.
2. Murase N, Starzl TE, Demetris AJ, et al. Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. Transplantation 1993; 55: 701.
3. Muphy B, Auchincloss H Jr, Carpenter CB, Sayegh MH. T cell recognition of xeno-MHC peptides during concordant xenograft rejection. Transplantation 1996; 61: 1133.
4. Kaufman CL, Gaines BA, Ildstad ST. Xenotransplantation. Annu Rev Immunol 1995;13: 339.
5. Bach FH, Winkler H, Ferran C, Hancock WW, Robson SC. Delayed xenograft rejection. Immunol Today 1996; 17: 379.
6. Steinbruchel DA. Pathogenesis and mechanisms of graft rejection in concordant xenotransplantation with special reference to hamster-to-rat cardiac transplantation. APMIS 1996; 104 (suppl): 5.
7. Lin Y, Vandeputte M, Waer M. NK cell- and macrophage-mediated rejection of concordant xenograft rejection in the absence of T- and B-cell responses. J Immunol 1997; 158: 5658.
8. Schorlemmer HU, Seiler FR, Bartlett RR. Prolongation of allogeneic transplanted skin grafts and induction of tolerance by leflunomide, a new immunosuppressive isoxazol derivative. Transplant Proc 1993; 25: 763.
9. Lang R, Wagner H, Heeg K. Differential effects of the immuno-suppressive agents cyclosporine and leflunomide in vivo. Transplantation 1995; 59: 382.
10. Williams JW, Xiao F, Foster P, Kociss K, Chong A, Sankary H. Leflunomide and cyclosporine A in rat cardiac transplantation. Transplant Proc 1993; 25: 745.
11. D'Silva M, Candinas D, Achilleos O, et al. The immunomodulatory effect of leflunomide in rat cardiac allotransplantation. Transplantation 1995; 60: 430.
12. Foster PF, Xiao F, Kociss K, et al. Leflunomide immunosuppression in rat small intestinal transplantation. Transplant Proc 1994; 26: 1599.
13. Niederkorn JY, Lang LS, Ross J, Robertson SM. Promotion of corneal allograft survival with leflunomide. Ophthalmol Vis Sci 1994; 35: 3783.
14. Cao WW, Kao PN, Chao AC, et al. Mechanism of the antiproliferative action of leflunomide. J Heart Lung Transplant 1995; 14: 1016.
15. Xiao F, Chong A, Shen J, et al. Pharmacologically induced regression of chronic transplant rejection. Transplantation 1995; 60: 1065.
16. Xiao F, Chong AS, Foster P, et al. Leflunomide controls rejection in hamster to rat cardiac xenografts. Transplantation 1994; 58: 828.
17. Thomas F, Araneda D, Quarantillo P. Long-term survival of disparate cardiac xenografts: induction of tolerance and humoral accommodation. Transplant Proc 1994; 26: 1220.
18. Chong ASF, Finnegan A, Jiang X, et al. Leflunomide, a novel immunosuppressive agent: the mechanism of inhibition of T cell proliferation. Transplantation 1993; 55: 1361.
19. Cherwinski HM, Cohn RG, Cheung P, et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 1995; 275: 1043.
20. Langer A, Valdivia LA, Murase N, et al. Humoral and cellular immunopathology of hepatic and cardiac master-into-rat xenograft rejection: marked stimulation of IgM++ bright/IgD+ dull splenic B cells. Am J Pathol 1993; 143: 85.
21. Chong ASF, Rezai K, Gebel HM, et al. Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro. Transplantation 1996; 61: 140.
22. Siemasko KF, Chong ASF, Williams JW, Bremer EG, Finnegan A. Regulation of B cell function by the immunosuppressive agent leflunomide. Transplantation 1996; 61: 635.
23. Chong ASF, Shen J, Xiao F, et al. Delayed xenograft rejection in the concordant hamster heart into Lewis rat model. Transplantation 1996; 62: 90.
24. Chong ASF, Ma, LL, Shen J, et al. Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts. Transplantation 1997; 64: 1650
25. Lin Y, Vandeputte M, Waer, M. Effect of leflunomide and cyclosporine on the occurrence of chronic xenograft lesions. Kidney Int 1995; 48: S23.
26. Lin Y, Vandeputte M, Waer, M. Accommodation and T-independent B cell tolerance in rats with long term surviving hamster heart xenografts. J Immunol 1997; 160: 369.
27. Fryer JP, Leventhal JR, Dalmasso AP, et al. Cellular rejection in discordant xenografts when hyperacute rejection is prevented: analysis using adoptive and passive transfer. Transplant Immunol 1994; 2: 87.
28. Kamada N. The immunology of experimental liver transplantation in the rat. Immunology 1985; 55: 369.
29. Xiao F, Chong A, Shen J, et al. Control and reversal of chronic rejection in hamster to rat cardiac transplantation. Transplant Proc 1996; 28: 691.