Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes

Human Molecular Genetics

Volumn 15, Issue 14, 2006, Pages 2216-2224

  Harries, Lorna W ^a,b   Ellard, Sian ^a   Stride, Amanda ^a   Morgan, Noel G ^a   Hattersley, Andrew T ^a   Vaxillaire, M ^c   Tuomi, T ^d   Barbetti, E ^e   Njolstad, P R ^f   Hansen, T ^g   Costa, A ^h   Congret, I ^h   Pedersen, O ^g   Sovik O ^f   Lorini, R ⁱ   Froguel, P ^c  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b ROYAL DEVON AND EXETER NHS FOUNDATION TRUST   (United Kingdom)

^c INSTITUT PASTEUR   (France)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e IBCIT Biomedical Science Park   (Italy)

^f UNIVERSITY OF BERGEN   (Norway)

^g STENO DIABETES CENTER   (Denmark)

^h UNIVERSITY OF BARCELONA   (Spain)

ⁱ UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 1ALPHA; ISOPROTEIN;

ADULT; AGED; ARTICLE; CELL FUNCTION; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; EXON; FEMALE; FETUS; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC CODE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOMER; KIDNEY PARENCHYMA; LIVER; MALE; MONOGENIC DISORDER; NUCLEOTIDE SEQUENCE; PANCREAS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; ALTERNATIVE SPLICING; BASE SEQUENCE; CHILD; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; MALE; MIDDLE AGED; MUTATION; PANCREAS; PHENOTYPE; PROTEIN ISOFORMS; RNA, MESSENGER;

EID: 33745597077     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddl147     Document Type: Article

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