Natural variation in toxicity of wheat: Potential for selection of nontoxic varieties for celiac disease patients

Gastroenterology

Volumn 129, Issue 3, 2005, Pages 797-806

  Spaenij Dekking, Liesbeth ^a   Kooy Winkelaar, Yvonne ^a   Van Veelen, Peter ^a   Drijfhout, Jan Wouter ^a   Jonker, Harry ^b   Van Soest, Loek ^b   Smulders, Marinus J M ^b   Bosch, Dirk ^b   Gilissen, Luud J W J ^b   Koning, Frits ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLUTEN;

AMINO ACID SEQUENCE; ARTICLE; CELIAC DISEASE; DIETARY INTAKE; DIPLOIDY; FOOD INTAKE; GENETIC VARIABILITY; GLUTEN FREE DIET; HEXAPLOIDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DATABASE; RISK REDUCTION; SEQUENCE ANALYSIS; T LYMPHOCYTE ACTIVATION; TETRAPLOIDY; VARIETAS; WHEAT;

EID: 24144461686     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.06.017     Document Type: Article

References (31)

1. R.P. Anderson, P. Degano, A.J. Godkin, D.P. Jewell, A.V. Hill In vivo antigen challenge in celiac disease identifies a single transglutaminase- modified peptide as the dominant A-gliadin T-cell epitope Nat Med 6 2000 337 342
2. B. Fleckenstein, O. Molberg, S.W. Qiao, D.G. Schmid, M.F. Von Der, K. Elgstoen, G. Jung, L.M. Sollid Gliadin T cell epitope selection by tissue transglutaminase in celiac disease J Biol Chem 277 2002 34109 34116
3. O. Molberg, S.N. McAdam, R. Korner, H. Quarsten, C. Kristiansen, L. Madsen, L. Fugger, H. Scott, O. Noren, P. Roepstorff, K.E. Lundin, H. Sjostrom, L.M. Sollid Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease Nat Med 4 1998 713 717
4. O. Molberg, S. McAdam, K.E. Lundin, C. Kristiansen, H. Arentz-Hansen, K. Kett, L.M. Sollid T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase Eur J Immunol 31 2001 1317 1323
5. H. Quarsten, O. Molberg, L. Fugger, S.N. McAdam, L.M. Sollid HLA binding and T cell recognition of a tissue transglutaminase-modified gliadin epitope Eur J Immunol 29 1999 2506 2514
6. H. Sjostrom, K.E. Lundin, O. Molberg, R. Korner, S.N. McAdam, D. Anthonsen, H. Quarsten, O. Noren, P. Roepstorff, E. Thorsby, L.M. Sollid Identification of a gliadin T-cell epitope in coeliac disease general importance of gliadin deamidation for intestinal T-cell recognition Scand J Immunol 48 1998 111 115
7. L.W. Vader, A. De Ru, W.Y. van der, Y.M. Kooy, W. Benckhuijsen, M.L. Mearin, J.W. Drijfhout, P. van Veelen, F. Koning Specificity of tissue transglutaminase explains cereal toxicity in celiac disease J Exp Med 195 2002 643 649
8. Y. van de Wal, Y. Kooy, P. van Veelen, S. Pena, L. Mearin, G. Papadopoulos, F. Koning Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity J Immunol 161 1998 1585 1588
9. K.E. Lundin, H. Scott, T. Hansen, G. Paulsen, T.S. Halstensen, O. Fausa, E. Thorsby, L.M. Sollid Gliadin-specific, HLA-DQ (alpha 1* (*)0501, beta 1* (*)0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients J Exp Med 178 1993 187 196
10. Y. van de Wal, Y.M. Kooy, P.A. van Veelen, S.A. Pena, L.M. Mearin, O. Molberg, K.E. Lundin, L.M. Sollid, T. Mutis, W.E. Benckhuijsen, J.W. Drijfhout, F. Koning Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin Proc Natl Acad Sci U S A 95 1998 10050 10054
11. E.M. Nilsen, K.E. Lundin, P. Krajci, H. Scott, L.M. Sollid, P. Brandtzaeg Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma Gut 37 1995 766 776
12. E.M. Nilsen, F.L. Jahnsen, K.E. Lundin, F.E. Johansen, O. Fausa, L.M. Sollid, J. Jahnsen, H. Scott, P. Brandtzaeg Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease Gastroenterology 115 1998 551 563
13. R.T. Przemioslo, K.E. Lundin, L.M. Sollid, J. Nelufer, P.J. Ciclitira Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon gamma antibody Gut 36 1995 874 879
14. P.R. Shewry, N.G. Halford Cereal seed storage proteins structures, properties and role in grain utilization J Exp Botany 53 2002 947 958
15. G. Paulsen, K.E. Lundin, H.A. Gjertsen, T. Hansen, L.M. Sollid, E. Thorsby HLA-DQ2-restricted T-cell recognition of gluten-derived peptides in celiac disease. Influence of amino acid substitutions in the membrane distal domain of DQ beta 1* (*)0201 Hum Immunol 42 1995 145 153
16. W. Vader, Y. Kooy, P. van Veelen, A. De Ru, D. Harris, W. Benckhuijsen, S. Pena, L. Mearin, J.W. Drijfhout, F. Koning The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides Gastroenterology 122 2002 1729 1737
17. Y. van de Wal, Y.M. Kooy, P. van Veelen, W. Vader, S.A. August, J.W. Drijfhout, S.A. Pena, F. Koning Glutenin is involved in the gluten-driven mucosal T cell response Eur J Immunol 29 1999 3133 3139
18. O. Molberg, F.N. Solheim, T. Jensen, K.E. Lundin, H. Arentz-Hansen, O.D. Anderson, U.A. Kjersti, L.M. Sollid Intestinal T-cell responses to high-molecular-weight glutenins in celiac disease Gastroenterology 125 2003 337 344
19. T. Marti, O. Molberg, Q. Li, G.M. Gray, C. Khosla, L.M. Sollid Prolyl endopeptidase mediated destruction of t cell epitopes in whole gluten - chemical and immunological characterization J Pharmacol Exp Ther 312 2005 19 26
20. J.L. Piper, G.M. Gray, C. Khosla Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo J Pharmacol Exp Ther 311 2004 213 219
21. L. Shan, O. Molberg, I. Parrot, F. Hausch, F. Filiz, G.M. Gray, L.M. Sollid, C. Khosla Structural basis for gluten intolerance in celiac sprue Science 297 2002 2275 2279
22. O.D. Anderson, J.C. Litts, F.C. Greene The alpha-gliadin gene family. I. Characterization of ten new wheat alpha-gliadin genomic clones, evidence for limited sequence conservation for flanking DNA, and southern analysis of the gene family Theor Appl Genet 95 1997 50 58
23. L.W. Vader, D.T. Stepniak, E.M. Bunnik, Y.M. Kooy, W. de Haan, J.W. Drijfhout, P.A. van Veelen, F. Koning Characterization of cereal toxicity for celiac disease patients based on protein homology in grains Gastroenterology 125 2003 1105 1113
24. E.H. Spaenij-Dekking, E.M. Kooy-Winkelaar, W.F. Nieuwenhuizen, J.W. Drijfhout, F. Koning A novel and sensitive method for the detection of T cell stimulatory epitopes of alpha/beta- and gamma-gliadin Gut 53 2004 1267 1273
25. R. van Eckert The PWG gliadin, a new reference material 2000 25 27 Proceedings of the 16th meeting Working Group on Prolamin Analysis and Toxicity. Sitges, Spain
26. H. Arentz-Hansen, R. Korner, O. Molberg, H. Quarsten, W. Vader, Y.M. Kooy, K.E. Lundin, F. Koning, P. Roepstorff, L.M. Sollid, S.N. McAdam The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase J Exp Med 191 2000 603 612
27. A. Ivarsson, L.A. Persson, L. Nystrom, H. Ascher, B. Cavell, L. Danielsson, A. Dannaeus, T. Lindberg, B. Lindquist, L. Stenhammar, O. Hernell Epidemic of coeliac disease in Swedish children Acta Paediatr 89 2000 165 171
28. M.L. Mearin, I. Biemond, A.S. Pena, I. Polanco, C. Vazquez, G.T. Schreuder, R.R. de Vries, J.J. van Rood HLA-DR phenotypes in Spanish coeliac children their contribution to the understanding of the genetics of the disease Gut 24 1983 532 537
29. W. Vader, D. Stepniak, Y. Kooy, L. Mearin, A. Thompson, J.J. van Rood, L. Spaenij, F. Koning The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses Proc Natl Acad Sci U S A 100 2003 12390 12395
30. F.M. van Overbeek, I.G. Uil-Dieterman, I.W. Mol, L. Kohler-Brands, H.S. Heymans, C.J. Mulder The daily gluten intake in relatives of patients with coeliac disease compared with that of the general Dutch population Eur J Gastroenterol Hepatol 9 1997 1097 1099
31. O. Molberg, A.K. Uhlen, T. Jensen, N. Solheim Flaete, B. Fleckenstein, H. Arentz-Hansen, M. Raki, K.E.A. Lundin, L.M. Sollid Mapping of gluten T-cell epitopes in bread wheat ancestors implications for celiac disease Gastroenterology 128 2005 393 401