Enhanced accumulation of tau in doubly transgenic mice expressing mutant βAPP and presenilin-1

Brain Research

Volumn 1094, Issue 1, 2006, Pages 192-199

  Samura, Eriko ^a   Shoji, Mikio ^a   Kawarabayashi, Takeshi ^a   Sasaki, Atsushi ^b   Matsubara, Etsuro ^c   Murakami, Tetsuro ^a   Wuhua, Xu ^a   Tamura, Shuta ^a   Ikeda, Masaki ^b   Ishiguro, Koich ^d   Saido, Takaomi C ^e,f   Westaway, David ^g   St George Hyslop, Peter ^g   Harigaya, Yasuo ^h   Abe, Koji ^a  

^a Department of Neurology   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^d MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^f UNIVERSITY OF TORONTO   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

^h MAEBASHI RED CROSS HOSPITAL   (Japan)

Author keywords

A ; Alzheimer's disease; Doubly transgenic mouse; Presenilin 1; Tau; Tg2576

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; TAU PROTEIN;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARGYROPHILIA; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FIBER; MOUSE; MOUSE STRAIN; NEURITE; NONHUMAN; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SOLUBILITY; TAUOPATHY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; MUTATION; NEURITES; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION; PRESENILIN-1; SENILE PLAQUES; TAU PROTEINS; UP-REGULATION;

MUS MUSCULUS;

EID: 33745258680     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.12.134     Document Type: Article

References (34)

1. Boutajangout A., Leroy K., Touchet N., Authelet M., Blanchard V., Tremp G., Pradier L., and Brion J.P. Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1. Neurosci. Lett. 318 (2002) 29-33
2. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St George Hyslop P., and Selkoe D.J. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat. Med. 3 (1997) 67-72
3. Dermaut B., Kumar-Singh S., Engelborghs S., Theuns J., Rademakers R., Saerens J., Pickut B.A., Peeters K., van den Broeck M., Vennekens K., Claes S., Cruts M., Cras P., Martin J.J., Van Broeckhoven C., and De Deyn P.P. A novel presenilin 1 mutation associated with Pick's disease but not β-amyloid plaques. Ann. Neurol. 55 (2004) 617-626
4. Games D., Adams D., Alessandrini R., Barbour R., Berthelette P., Blackwell C., Carr T., Clemes J., Donaldson T., Gillespie F., Guido T., Hagopian S., Johnson-Wood K., Khan K., Lee M., Leibowitz P., Lieberburg I., Little S., Masliah E., McConlogue l., Montoya-Zavala M., Mucke L., Paganini L., Penniman E., Power M., Schenk D., Seubert P., Snyder B., Soriano F., Tan H., Vitale J., Wadsworth S., Wolozin B., and Zhao J. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373 (1995) 523-527
5. Gotz J., Chen F., van Dorpe J., and Nitsch R.M. Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils. Science 293 (2001) 1491-1495
6. Greenberg S.G., and Davies P. A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 5827-5831
7. Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., Sanders S., Zehr C., O'Campo K., Hardy J., Prada C.M., Eckman C., Younkin S., Hsiao K., and Duff K. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4 (1998) 97-100
8. Hoshi M., Sato M., Matsumoto S., Noguchi A., Yasutake K., Yoshida N., and Sato K. Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6370-6375
9. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., and Cole G. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274 (1996) 99-102
10. Ishiguro K., Sato K., Takamatsu M., Park J., Uchida T., and Imahori K. Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites. Neurosci. Lett. 202 (1995) 81-84
11. Ishiguro K., Ohno H., Arai H., Yamaguchi H., Urakami K., Park J.M., Sato K., Kohno H., and Imahori K. Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease. Neurosci. Lett. 270 (1999) 91-94
12. Kawarabayashi T., Younkin L.H., Saido T.C., Shoji M., Ashe K.H., and Younkin S.G. Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci. 21 (2001) 372-381
13. Kawarabayashi T., Shoji M., Younkin L.H., Wen-Lang L., Dickson D.W., Murakami T., Matsubara E., Abe K., Ashe K.H., and Younkin S.G. Dimeric amyloid β protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 24 (2004) 3801-3809
14. Kurt M.A., Davies D.C., Kidd M., Duff K., and Howlett D.R. Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiol. Dis. 14 (2003) 89-97
15. Le W., Xie W.J., Kong R., and Appel S.H. β-Amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of β-amyloid precursor protein. J. Neurochem. 69 (1997) 978-985
16. Le R., Cruz L., Urbanc B., Knowles R.B., Hsiao-Ashe K., Duff K., Irizarry M.C., Stanley H.E., and Hyman B.T. Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption. J. Neuropathol. Exp. Neurol. 60 (2001) 753-758
17. Le T.V., Crook R., Hardy J., and Dickson D.W. Cotton wool plaques in non-familial late-onset Alzheimer disease. J. Neuropathol. Exp. Neurol. 60 (2001) 1051-1061
18. Lewis J., Dickson D.W., Lin W.L., Chisholm L., Corral A., Jones G., Yen S.H., Sahara N., Skipper L., Yager D., Eckman C., Hardy J., Hutton M., and McGowan E. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293 (2001) 1487-1491
19. Masliah E., Sisk A., Mallory M., and Games D. Neurofibrillary pathology in transgenic mice overexpressing V717F β-amyloid precursor protein. J. Neuropathol. Exp. Neurol. 60 (2001) 357-368
20. McGowan E., Sanders S., Iwatsubo T., Takeuchi A., Saido T., Zehr C., Yu X., Uljon S., Wang R., Mann D., Dickson D., and Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol. Dis. 6 (1999) 231-244
21. Pigino G., Pelsman A., Mori H., and Busciglio J. Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J. Neurosci. 21 (2001) 834-842
22. Planel E., Yasutake K., Fujita S.C., and Ishiguro K. Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3β and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. J. Biol. Chem. 276 (2001) 34298-34306
23. Rank K.B., Pauley A.M., Bhattacharya K., Wang Z., Evans D.B., Fleck T.J., Johnston J.A., and Sharma S.K. Direct interaction of soluble human recombinant tau protein with Aβ1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II. FEBS Lett. 514 (2002) 263-268
24. Saido T.C., Iwatsubo T., Mann D.M., Shimada H., Ihara Y., and Kawashima S. Dominant and differential deposition of distinct β-amyloid peptide species AβN3(pE), in senile plaques. Neuron 14 (1995) 457-466
25. Sasaki A., Shoji M., Harigaya Y., Kawarabayashi T., Ikeda M., Naito M., Matsubara E., Abe K., and Nakazato Y. Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites. Virchows Arch. 441 (2002) 358-367
26. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., and Younkin S. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and βAPP mutations linked to familial Alzheimer's disease. Nat. Med. 2 (1996) 864-870
27. Suzuki N., Cheung T.T., Cai X.D., Odaka A., Otvos Jr. L., Eckman C., Golde T.E., and Younkin S.G. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants. Science 264 (1994) 1336-1340
28. Sturchler-Pierrat C., Abramowski D., Duke M., Wiederhold K.H., Mistl C., Rothacher S., Ledermann B., Burki K., Frey P., Paganetti P.A., Waridel C., Calhoun M.E., Jucker M., Probst A., Staufenbiel M., and Sommer B. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 13287-13292
29. Tomidokoro Y., Harigaya Y., Matsubara E., Ikeda M., Kawarabayashi T., Shirao T., Ishiguro K., Okamoto K., Younkin S.G., and Shoji M. Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. J. Pathol. 194 (2001) 500-506
30. Tomidokoro Y., Ishiguro K., Harigaya Y., Matsubara E., Ikeda M., Park J.M., Yasutake K., Kawarabayashi T., Okamoto K., and Shoji M. Aβ amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice. Neurosci. Lett. 299 (2001) 169-172
31. Verkkoniemi A., Kalimo H., Paetau A., Somer M., Iwatsubo T., Hardy J., and Haltia M. Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype. J. Neuropathol. Exp. Neurol. 60 (2001) 483-492
32. Wengenack T.M., Whelan S., Curran G.L., Duff K.E., and Poduslo J.F. Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain. Neuroscience 101 (2000) 939-944
33. Wolozin B.L., Pruchnicki A., Dickson D.W., and Davies P. A neuronal antigen in the brains of Alzheimer patients. Science 232 (1986) 648-650
34. Zheng W.H., Bastianetto S., Mennicken F., Ma W., and Kar S. Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures. Neuroscience 115 (2002) 201-211