Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites

Virchows Archiv

Volumn 441, Issue 4, 2002, Pages 358-367

  Sasaki, Atsushi ^a   Shoji, Mikio ^c   Harigaya, Yasuo ^a   Kawarabayashi, Takeshi ^a   Ikeda, Masaki ^a   Naito, Makoto ^b   Matsubara, Etsuro ^c   Abe, Koji ^c   Nakazato, Yoichi ^a  

^a GUNMA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Amyloid protein; Microglia; Senile plaques; Transgenic models

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CD11B ANTIGEN; CHLORDANE; COLONY STIMULATING FACTOR 1; RECEPTOR SUBTYPE;

AGED; ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOPLASM; DENSE BODY; ELECTRON MICROSCOPY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYSOSOME; MALE; MICROGLIA; MOUSE; NEURITE; NONHUMAN; PATHOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; SENILE PLAQUE; SILVER IMPREGNATION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BRAIN; CONGO RED; DISEASE MODELS, ANIMAL; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOHISTOCHEMISTRY; MACROPHAGE-1 ANTIGEN; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MICROGLIA; MICROSCOPY, IMMUNOELECTRON; NEURITES; NEUROFIBRILLARY TANGLES; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; SENILE PLAQUES;

EID: 0036913139     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-002-0643-8     Document Type: Article

References (34)

1. Andersson PB, Perry VH, Gordon S (1991) The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration. Neuroscience 42:201-214
2. Apelt J, Schliebs R (2001) β-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology. Brain Res 894:21-30
3. Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T (2000) Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916-919
4. Bohatschek M, Jones LL, Kreutzberg GW, Raivich G (1998) Expression of immunoregulatory molecules MHC1, MHC2 and B7-2 in the axotomized mouse facial motor nucleuss. Clin Neuropathol 17:286
5. Bornemann KD, Wiederhold KH, Pauli C, Ermini F, Stalder M, Schnell L, Sommer B, Jucker M, Staufenbiel M (2001) Aβ-induced inflammatory processes in microglia cells of APP23 transgenic mice. Am J Pathol 158:63-73
6. Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TVP, Hyman BT, Younkin SG, Hsiao KK (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 2:271-276
7. Dickson DW, Farlo J, Davies P, Crystal H, Schenk D, Games D (1988) A double-labeling immunohistochemical study of senile plaques. Am J Pathol 132:86-101
8. EI Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD (1996) Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature 382:716-719
9. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152:307-317
10. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J (1995) Alzheimer-type neuropathology in transgenic mice overexpresing V717F β-amyloid precursor protein. Nature 373:523-527
11. Giulian D, Haverkamp LJ, Yu JH, Karshin W, Tom D, Li J, Kirkpatrick J, Kuo LM, Roher AE (1996) Specific domains of β-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J Neurosci 16:6021-6037
12. Gravina SA, Ho L, Eckman CB, Long KE, Otvos Jr L, Younkin LH, Suzuki Y, Younkin SG (1995) Amyloid β protein (Aβ) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for at Aβ40 or Aβ42(43). J Biol Chem 270:7013-7016
13. Holness CL, da Silva RP, Fawcett J, Gordon S, Simmons DL (1993) Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family. J Biol Chem 268:9661-9666
14. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274:99-102
15. Irizarry MC, McNamara M, Fedorchak K, Hsiao K, Hyman BT (1997) APPsw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol 56:965-973
16. Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D (1989) Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol 24:173-182
17. Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Hsiao K, Younkin SG (2001) Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21:372-381
18. Lawson LJ, Frost L, Risbridger J, Fearn S, Perry VH (1994) Quantification of the mononuclear phagocyte response to Wallerian degeneration of the optic nerve. J Neurocytol 23:729-744
19. Masliah E, Mallory M, Deerinck T, deTeresa R, Lamont S, Miller A, Terry RD, Carragher B, Ellisman M (1993) Re-evaluation of the structural organization of neuritic plaques in Alzheimer's disease. J Neuropathol Exp Neurol 52:619-632
20. Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D (1996) Comparison of neurodegenerative pathology in trans-genic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease. J Neurosci 16:5795-5811
21. Mackenzie IR, Hao C, Munoz DG (1995) Role of microglia in senile plaque formation. Neurobiol Aging 16:797-804
22. McDonald DR, Brunden KR, Landreth GE (1997) Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci 17:2284-2294
23. Meda L, Cassatella MA, Szendrei GI, Otvos Jr L, Baron P, Villalba M, Ferrari D, Rossi F (1995) Activation of microglial cells by β-amyloid protein and interferon-r. Nature 374:647-650
24. Naito M, Kodama T, Matsumoto A, Doi T, Tkahashi K (1991) Tissue distribution, intracellular localization, and in vitro expression of bovine scavenger receptor. Am J Pathol 139:1411-1423
25. Sasaki A, Yamaguchi H, Ogawa A, Sugihara S, Nakazato Y (1997) Microglial activation in early stages of amyloid β protein deposition. Acta Neuropathol 94:316-322
26. Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberbung I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P (1999) Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-177
27. Stalder M, Phinney A, probst A, Sommer B, Staufenbiel M, Jucker M (1999) Association of microglia with amyloid plaques in brains of APP23 transgenic mice. Am J Pathol 154:1673-1684
28. Streit WJ, Graeber MB, Kreutzberg GW (1989) Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury. Exp Neurol 105:115-116
29. Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Okamoto K, Shoji M (2001) Aβ amyloidosis induces the initial stage of tau accumulation in APPsw mice. Neurosci Lett 299:169-172
30. Walker DG (1998) Inflammatory markers in chronic neurode-generative disorders with emphasis on Alzheimer's disease. In: PL Wood (ed) Neuroinflammation, Mechanisms and Management. Humana Press, Inc. Totowa, pp 61-90
31. Westerman MA, Cooper-Blacketer D, Gomez-Isla T, Mariash A, Ashe KH (2000) Age-dependent behavioral deficit in a transgenic mouse model of Alzheimer's disease. Soc Neurosci Abstr 26:1318
32. Wyss-Coray T, Lin C, Yan F, Yu G-Q, Rohde M, MaConlogue L, Masliah E, Mucke L (2001) TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice. Nat Med 7:612-618
33. Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Ihara Y (1988) A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by β protein immunostaining. Acta Neuropathol 76:541-549
34. Yamaguchi H, Nakazato Y, Shoji M, Takatama M, Hirai S (1991) Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: Comparison with primitive plaques. Acta Neuropathol 82:13-20