Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus

Journal of Physiology

Volumn 559, Issue 3, 2004, Pages 729-737

  Zhang, Weizhen ^a   Lin, Theodore R ^a   Hu, Yuexuan ^a   Fan, Yongyi ^c   Zhao, Lili ^a   Stuenkel, Edward L ^b   Mulholland, Michael W ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CALCIUM CHANNEL L TYPE; CALCIUM ION; DILTIAZEM; GASTROINTESTINAL HORMONE; GHRELIN; GHRELIN RECEPTOR; GROWTH HORMONE; HORMONE RECEPTOR; MESSENGER RNA; PEPTIDE HORMONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; BRAIN NERVE CELL; CALCIUM CURRENT; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; ENERGY BALANCE; GROWTH HORMONE RELEASE; HORMONAL REGULATION; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOTONEURON NUCLEUS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; TIME; VAGOTOMY; VAGUS NERVE DORSAL NUCLEUS;

ANIMALS; CELL DIVISION; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NEURONS; PEPTIDE HORMONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; VAGUS NERVE;

EID: 4644244251     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2004.064121     Document Type: Article

References (38)

1. Alvarez-Buylla A & Garcia-Verdugo JM (2002). Neurogenesis in adult subventricular zone. J Neurosci 22, 629-634.
2. Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV et al. (2000). Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 43, 4370-4376.
3. Chang H-M, Lue J-H, Wen C-Y & Shieh J-Y (2001). Axotomy along with hypoxia enhances the neuronal NADPH-d/NOS expression in lower brain stem motor neurons of adult rats. Exp Neurol 171, 116-126.
4. Chen C, Wu D & Clarke IJ (1996). Signal transduction systems employed by synthetic GH-releasing peptides in somatotrophs. J Endocrinol 148, 381-386.
5. Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL et al. (2003). The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37, 649-661.
6. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T et al. (2000). Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141, 4255-4261.
7. Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H et al. (2002). Ghrelin is present in pancreatic a cells of humans and rats and stimulates insulin secretion. Diabetes 51, 124-129.
8. Date Y, Nakazato M, Kojima M, Kuroiwa T, Matsukura S, Kangawa K & Nakazato M (2001). Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 280, 904-907.
9. Dolmetsch RE, Pajvani U, Fife K, Spotts JM & Greenberg ME (2001). Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 294, 333-339.
10. Faulconbridge LF, Cummings DE, Kaplan JM & Grill HJ (2003). Hyperphagic effects of brainstem ghrelin administration. Diabetes 52, 2260-2265.
11. Gross PM, Wall KM, Pang JJ, Shaver SW & Wainman DS (1990). Microvascular specializations promoting rapid interstitial solute dispersion in nucleus tractus solitarius. Am J Physiol 259, R1131-R1138.
12. Hayashida T, Nakahara K, Mondal MS, Date Y, Nakazato M, Kojima M et al. (2002). Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol 173, 239-245.
13. Hermann GE, Emch GS, Tovar CA & Rogers RC (2001). c-fos generation in the dorsal vagal complex after systemic endotoxin is not dependent on the vagus nerve. Am J Physiol 280, R289-R299.
14. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Charles I et al. (1996). A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273, 974-977.
15. Jacques TS, Skepper JN & Navaratnam V (1999). Fibroblast growth factor-1 improves the survival and regeneration of rat vagal preganglionic neurons following axon injury. Neurosic Lett 276, 197-200.
16. Jin K, Mao XO, Sun Y, Xie L & Greebberg DA (2002a). Stem cell factor stimulates neurogenesis in vitro and in vivo. J Clin Invest 110, 311-319.
17. Jin K, Zhu Y, Sun Y, Mao XO, Xie L & Greenberg DA (2002b). Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci U S A 99, 11946-11950.
18. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656-660.
19. Laiwand R, Werman R & Yarom Y (1987). Time course and distribution of motoneuronal loss in the dorsal motor vagal nucleus of guinea pig after cervical vagotomy. J Comp Neurol 256, 527-537.
20. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z et al. (2000). Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276, 905-908.
21. McKee KK, Palyha OC, Feighner SD, Hreniuk DL, Tan CP, Phillips MS et al. (1997). Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Mol Endocrinol 11, 415-423.
22. Mori K, Yoshimoto A, Takaya K, Hosoda K, Ariyasu H, Yahata K et al. (2000). Kidney produces a novel acylated peptide, ghrelin. FEBS Lett 486, 213-216.
23. Munoz-Sanjuan I & Brivanlou AH (2002). Neural induction, the default model and embryonic stem cells. Nature Rev Neurosci 3, 271-280.
24. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K & Matrukura S (2001). A role for ghrelin in the central regulation of feeding. Nature 409, 194-198.
25. Papotti M, Ghe C, Cassoni P, Catapano F, Deghenghi R, Ghigo E & Muccioli G (2000). Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 85, 3803-3807.
26. Paxinos G & Watson C (1998). The rat brain in stereotaxic coordinates. 4th Edition, Academic Press, San Diego.
27. Pettersson I, Muccioli G, Granata R, Deghenghi R, Ghigo E, Ohlsson C et al. (2002). Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation. J Endocrinol 175, 201-209.
28. Powley TL, Martinson FA, Phillips RJ, Jones S, Baronowsky EA & Swithers SE (2001). Gastrointestinal projection maps of the vagus nerve are specified permanently in the perinatal period. Brain Res Dev Brain Res 129, 57-72.
29. Sakata I, Tanaka T, Matsubara M, Yamazaki M, Tani S, Hayashi Y et al. (2002). Postnatal changes in ghrelin mRNA expression and in ghrelin-producing cells in the rat stomach. J Endocrinol 174, 463-471.
30. Seri B, Garcia-Verdugo JM, McEwen BS & Alvarez-Buylla A (2001). Astrocytes give rise to new neurons in the adult mammalian hippocampus. J Neurosci 21, 7153-7160.
31. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M et al. (2000). Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85, 4908-4911.
32. Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P & Poitras P (2002). Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol 282, G948-G952.
33. Tschop M, Smiley DL & Heiman ML (2000). Ghrelin induces adiposity in rodents. Nature 407, 908-913.
34. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S et al. (2000). The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141, 4325-4328.
35. Yokote R, Sato M, Matsubara S, Ohye H, Niimi M, Murao K & Takahara J (1998). Molecular cloning and gene expression of growth hormone-releasing peptide receptor in rat tissues. Peptides 19, 15-20.
36. Yuan P-Q & Yang H (2002). neuronal activation of brain vagal-regulatory pathways and upper gut enteric plexues by insulin hypoglycemia. Am J Physiol Endocrinol Metab 283, E436-E448.
37. Zhang W, Chen M, Chen X, Segura BJ & Mulholland MW (2001). Inhibition of pancreatic protein secretion by ghrelin in rat. J Physiol 537, 231-236.
38. Zhang W, Zhao L, Lin TR, Chai B, Fan Y, Gantz I et al. (2004). Inhibition of adipogenesis by ghrelin. Mol Biol Cell 15, 2484-2491.