Growth hormone secretagogue receptor expression in human pituitary tumors

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 12, 1998, Pages 4314-4320

  Skinner, Monica M ^a   Nass, Ralf ^a   Lopes, Beatriz ^a   Laws, Edward R ^a   Thorner, Michael O ^a,b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; FOLLITROPIN; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE RELEASING FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROCORTISONE; INOSITOL TRISPHOSPHATE; LUTEINIZING HORMONE; NEUROTENSIN RECEPTOR; PROTEIN KINASE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; THYROTROPIN;

ARTICLE; CALCIUM CELL LEVEL; CLINICAL ARTICLE; FEEDBACK SYSTEM; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; NEGATIVE FEEDBACK; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH;

EID: 0032468862     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.12.4314     Document Type: Article

References (46)

1. 1. Yamada Y, Reisine T, Law SF, et al. 1992 Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cylcase. Mol Endocrinol. 6:2136-2142.
2. 2. Buscail L, Delesque N, Esteve JP, et al. 1994 Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2. Proc Natl Acad Sci USA. 91:2315-2319.
3. 3. Jakobs KH, Aktories K, Schultz G. 1983 A nucleotide regulatory site for somatostatin inhibition of adenylyl cylclase in S49 lymphoma cells. Nature. 303:177-178.
4. 4. Dhanasekaran N, Heasley LE, Johnson GL. 1995 G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr Rev. 16:259-270.
5. 5. Burton KA, Kabigting EB, Clifton DK, Steiner RA. 1992 Growth-hormone receptor messenger-ribonucleic-acid distribution in the adult male-rat brain and its colocalization in hypothalamic somatostatin neurons. Endocrinology. 131:958-963.
6. 6. Bennett PA, Levy A, Sophokleous S, Robinson ICAF, Lightman SL. 1995 Hypothalamic GH receptor gene expression in the rat: effects of altered GH status. J Endocrinol. 147:225-234.
7. 7. Smith RG, Cheng K, Pong SS, et al. 1996 Mechanism of action of GHRP-6 and nonpeptidyl growth hormone secretagogues. In: Bercu BB, Walker RF, eds. Growth hormone secretagogues. New York: Springer-Verlag; 147-163.
8. 8. Smith RG, Van der Ploeg LHT, Howard AD, et al. 1997 Peptidomimetic regulation of growth hormone secretion. Endocr Rev. 18:621-645.
9. 9. Dickson SL, Leng G, Dyball REJ, Smith RG. 1995 Central actions of peptide and nonpeptide growth hormone secretagogues in the rat. Neuroendocrinology. 61:36-43.
10. 10. Dickson SL, Luckman SD. 1997 Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurones in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6. Endocrinology. 138:771-777.
11. 11. Fletcher TP, Thomas GB, Clarke IJ. 1996 Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6. Dom Anim Endocrinol. 13:251-258.
12. 12. Guillaume V, Magnan E, Cataldi M, et al. 1994 Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep. Endocrinology. 135:1073-1076.
13. 13. Bowers CY, Momany FA, Reynolds GA, Hong A. 1984 On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 114:1537-1545.
14. 2 on GRF stimulated growth hormone release and intracellular cAMP accumulation in rat primary pituitary cell cultrues. Endocrinology. 124:2791-2797.
15. 15. Smith RG, Pong SS, Hickey GJ, et al. 1996 Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland. Recent Prog Horm Res. 51:261-286.
16. 16. Pong SS, Chaung LYP, Leonard RJ. The involvement of ions in the activity of a novel growth hormone secretagogue L-692,429 in rat pituitary cell culture. Proc of the 75th Annual Meet of The Endocrine Soc. 1993; 487.
17. 17. Bresson-Bepoldin L, Dufy-Barbe L. 1994 GHRP-6 induces a biphasic calcium response in rat pituitary somatotrophs. Cell Calcium. 15:247-258.
18. 18. Herrington J, Hille B. 1994 Growth hormone-releasing hexapeptide elevates intracellular calcium in rat somatotrophs by two mechanisms. Endocrinology. 135:1100-1108.
19. 19. Lei T, Buchfelder M, Fahlbusch R, Adams EF. 1995 Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells. J Mol Endocrinol. 14:135-138.
20. 2-induced growth hormone release from rat primary pituitary cells. Endocrinology. 129:3337-3342.
21. 21. Howard AD, Feighner SD, Cully DF, et al. 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 273:974-977.
22. 22. Guan XM, Hong Y, Palyha OC, et al. 1997 Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Mol Brain Res. 48:23-29.
23. 23. Shimon I, Yan X, Melmed S. 1998 Human fetal pituitary expresses functional growth hormone-releasing peptide receptors. J Clin Endocrinol Metab. 83:174-178.
24. 24. Bennett PA, Thomas GB, Howard AD, et al. 1997 Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat. Endocrinology. 138:4552-4557.
25. 25. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S. 1990 Clonal origin of pituitary adenomas. J Clin Endocrinol Metab. 71:1427-1433.
26. 26. Reichlin S. 1980 Etiology of pituitary adenomas. In: Post KD, Jackson IMD, Reichlin S, eds. The pituitary adenoma. New York and London: Plenum Press; 29-42.
27. 27. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A. 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest. 86:336-340.
28. 28 Biller BM, Alexander JM, Zervas NT, Hedley-Whyte ET, Arnold A, Klibanski A. 1992 Clonal origins of adrenocorticotropin-secreting pituitary tissue in Cushing's disease. J Clin Endocrinol Metab. 75:1303-1309.
29. 29. Shimon I, Melmed S. 1997 Genetic basis of endocrine disease: pituitary tumor pathogenesis. J Clin Endocrinol Metab. 82:1675-1681.
30. 30. Faglia G, Spada A. 1995 The role of the hypothalamus in pituitary neoplasia. Bailliere Clin Endocrinol Metab. 9:225-242.
31. 31. Molitch ME. 1995 Prolactinoma. In: Melmed S, ed. The pituitary. Cambridge: Blackwell; 443-477.
32. 32. Ezzat S, Snyder PJ, Young WF, et al. 1992 Octreotide treatment of acromegaly: a randomized, multicenter study. Ann Intern Med. 117:711-718.
33. 33. Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A. 1995 Somatostatin receptor subtype gene expression in pituitary adenomas. J Clin Endocrinol Metab. 80:1386-1392.
34. 34. Lopes MB, Gaylinn BD, Thorner MO, Stoler MH. 1997 Growth hormone-releasing hormone receptor mRNA in acromegalic pituitary tumors. Am J Pathol. 150:1885-1891.
35. 35. Greenman Y, Melmed S. Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors. J Clin Endocrinol Metab. 78:398-403.
36. 36. Cheng K, Chan WW, Butler B, et al. 1993 Stimulation of growth hormone release from rat primary pituitary cells by L-692,429, a novel non-peptidyl GH secretagogue. Endocrinology. 132:2729-2731.
37. 37. Popovic V, Damjanovic S, Micic D, Petakov M, Dieguez C, Casanueva FF. 1994 Growth hormone (GH) secretion in active acromegaly after the combined administration of GH-releasing hormone and GH-releasing peptide-6. J Clin Endocrinol Metab. 79:456-460.
38. 38. Renner U, Brockmeier S, Strasburger CJ, et al. 1994 Growth hormone (GH)-releasing peptide stimulation of GH release from human somatotroph adenoma cells: interaction with GH-releasing hormone, thyrotropin-releasing hormone, and octreotide. J Clin Endocrinol Metab. 78:1090-1096.
39. 3 cells. J Clin Endocrinol Metab. 83:638-642.
40. 2), GH-releasing hormone, and thyrotropin-releasing hormone in acromegaly. J Clin Endocrinol Metab. 77:842-845.
41. 41. Spada A, Elahi FR, Arosio M, et al. 1987 Lack of desensitization of adenomatous somatotrophs to growth-hormone releasing hormone in acromegaly. J Clin Endocrinol Metab. 64:585-591.
42. 42. Thapar K, Kovacs K, Stefaneanu L, et al. 1997 Overexpression of the growth-hormone-releasing hormone gene in acromegaly-associated pituitary tumors. Am J Pathol. 1551:769-784.
43. 43. Jacks T, Hickey G, Judith F, et al. 1994 Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. J Endocrinol. 143:399-406.
44. 44. Ghigo E, Arvat E, Ramunni J, et al. 1997 Adrenocorticotropin-and cortisol-releasing effect of hexarelin, a synthetic growth hormone-releasing peptide, in normal subjects and patients with Cushing's syndrome. J Clin Endocrinol Metab. 82:2439-2444.
45. 45. Jaffe CA, DeMott-Friberg R, Frohman LA, Barkan AL. 1997 Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist. J Clin Endocrinol Metab. 82:634-637.
46. 46. Kovacs M, Kineman RD, Schally AV, Zarandi M, Groot K, Frohman LA. 1997 Effects of antagonists of growth hormone-releasing hormone (GHRH) on GH and insulin-like growth factor I levels in transgenic mice overexpressing the human GHRH gene, an animal model of acromegaly. Endocrinology. 138: 4536-4542.