Expression of functional growth hormone secretagogue receptors in human pituitary adenomas: Polymerase chain reaction, triple in-situ hybridization and cell culture studies

Journal of Neuroendocrinology

Volumn 11, Issue 7, 1999, Pages 491-502

  Barlier, A ^a,d   Zamora, A J ^a   Grino, M ^b   Gunz, G ^a   Pellegrini Bouiller, I ^a   Morange Ramos, I ^a,c   Figarella Branger, D ^c   Dufour, H ^c   Jaquet, P ^a,c   Enjalbert, A ^a  

^a CNRS   (France)

^b INSERM   (France)

^c TIMONE HOSPITAL   (France)

^d AIX MARSEILLE UNIVERSITY   (France)

Author keywords

GHRP; GHS receptors; In situ hybridization; MK 0677; Pituitary adenoma

Indexed keywords

CORTICOTROPIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; IBUTAMOREN; MESSENGER RNA; PROLACTIN; THYROTROPIN;

ADULT; AGED; ARTICLE; CELL CULTURE; CORTICOTROPIN RELEASE; DOSE RESPONSE; FEMALE; GROWTH HORMONE RELEASE; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IN SITU HYBRIDIZATION; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROLACTIN RELEASE; RECEPTOR GENE; SEQUENCE ANALYSIS;

ADENOMA; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; BASE SEQUENCE; DNA PRIMERS; FEMALE; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HUMANS; IN SITU HYBRIDIZATION; INDOLES; MALE; MIDDLE AGED; PITUITARY NEOPLASMS; PROLACTIN; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPIRO COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0033066368     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1999.00351.x     Document Type: Article

References (43)

1. Ghigo E, Arvat E, Miccioli G, Camanni F. Growth hormone-releasing peptides. Eur J Endocrinol 1997; 136: 445-460.
2. Smith RG, Van der Ploeg LHT, Howard AD, Feighner SD, Cheng K, Hickey GJ, Wyvratt MJ, Fisher MH, Nargund RP, Patchett AA. Peptidomimetic regulation of growth hormone secretion. Endocr Rev 1997; 18: 621-645.
3. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong S-S, Chaung L-Y, Elbrecht Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJS, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin JA, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LHT. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974-977.
4. McKee KK. Palyha OC, Feighner SD, Hreniuk DL, Tan CP, Philips MS, Smith RG, Van der Ploeg LHT, Howard AD. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Mol Endocrinol 1997; 11: 415-423.
5. Zimmerman D, Young W, Ebersold MJ, Scheithauer BW, Kovacs K, Horvath E, Whitaker MD, Eberhardt NL, Downs TR, Frohman LA. Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. J Clin Endocrinol Metab 1993; 76: 216-222.
6. Billestrup N, Swanson LW, Vale W. Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci USA 1986; 83: 6854-6857.
7. Asa SL, Kovacs K, Stefaneanu L, Horvath E, Billestrup N, Gonzales-Manchon C, Vale W. Pituitary adenomas in mice transgenic for growth hormone-releasing hormone. Endocrinology 1992; 131: 2083-2089.
8. Shimon I, Melmed S. Pituitary tumor pathogenesis. J Clin Endocrinol Metab 1997; 82: 1675-1681.
9. Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO. Growth hormone (GH) -releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J Clin Endocrinol Metab 1990; 70: 975-982.
10. Gertz BJ, Barrett JS, Eisenhandler R, Krupa DA, Wittreich JM, Seibold JR, Schneider SH. Growth hormone response in Man to L-692-429, a novel nonpeptide mimic of growth hormone-releasing peptide-6. J Clin Endocrinol Metab 1993; 77: 1393-1397.
11. Spada A, Vallar L, Faglia G. G proteins and hormonal signalling in human pituitary tumors: genetic mutations and functional alterations. Front Neuroendocrinol 1993; 14: 214-232.
12. Perraudin V, Delarue C, de Keyser Y, Bertagna X, Kuhn J-M. Contesse V, Clauser E, Vaudry H. Vasopressin-responsive adrenocortical tumor in a mild Cushing's syndrom: in vivo and in vitro studies. J Clin Endocrinol Metab 1995; 80: 2661-2667.
13. Barlier A, Gunz G, Zamora AJ, Morange-Ramos I, Figarella-Branger D, Dufour H, Enjalbert A, Jaquet P. Pronostic and therapeutic consequences of Gs' mutations in somatotroph adenomas. J Clin Endocrinol Metab 1998; 83: 1604-1610.
14. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol chloroform extraction. Anal Biochem 1987; 162: 156-159.
15. Pellegrini I, Barlier A, Gunz G, Figarella-Branger D, Enjalbert A, Grisoli F, Jaquet P. Pit-1 gene expression in the human pituitary and pituitary adenomas. J Clin Endocrinol Metab 1994; 79: 189-196.
16. Grino M, Zamora AJ. In situ hybridization histochemistry technique allowing simulatoneous visualization by the use of confocal microscopy of three mRNA species in individual neurons. J Histochem Cytochem 1998; 46: 753-759.
17. Jaquet P, Gunz G, Grisoli F. Hormonal regulation of prolactin release by human prolactinoma cells cultured in serum-free conditions. Horm Res 1985; 22: 153-163.
18. Adams EF, Huang B, Buchfelder M, Howard A, Smith RG, Feighner SD, Van der Ploeg LHT, Bowers CY, Fahlbusch R. Presence of growth hormone secretagogue receptor messenger ribonucleic acid in human pituitary tumors and rat GH3 cells. J Clin Endocrinol Metab 1998; 83: 638-642.
19. De Keyzer Y, Lenne F, Bertagna X. Widespread transcription of the growth hormone releasing peptide receptor gene in neuroendocrine human tumors. European J Endocrinol 1997; 137: 715-718.
20. Nielsen S, Mellemkjaer S, Rasmussen LM, Ledet T, Astrup J, Weeke J, Jorgensen JOL. Gene transcription of receptors for growth hormone-releasing peptide and somatostatin in human pituitary adenomas. J Clin Endocrinol Metab 1998; 83: 2997-3000.
21. Chapman IM, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KT, Skiles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO. Stimulation of the growth hormone (GH )-insulin-like growth factor 1 axis by daily oral administration of a GH secretagogue (MK-0677) in healthy elderly subjects. J Clin Endocrinol Metab 1996; 81: 4249-4257.
22. Bowers CY, Momany FA, Reynolds GA, Hong A. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically. Endocrinology 1984; 114: 1537-1545.
23. Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, Johnston DBR, Cheng K, Chan WWS, Butler B, Hickey G, Jacks T. Schleim K, Pong SS, Chaung L-YP, Chen HY, Frazier E, Leung KH, Chiu S-, Hl Smith RG. Design and biological activities of L-163, 191 (MK 0677): a potent, orally active growth hormone secrelagogue. Proc Natl Acad Sci USA 1995; 92: 7001-7005.
24. Jacks T, Smith R, Judith F, Schleim K, Frazier E, Chen H, Krupa D, Hora D, Nargund R, Patchett A, Hickey G. MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, Insulin-like growth factor I, and other hormonal responses in Beagles. Endocrinology 1996; 137: 5284-5289.
25. Elias KA, Ingle GS, Burnier JP, Hammonds G, McDowell RS, Rawson TE, Somers TC, Stanley MS, Cronin MJ. In vitro characterization of four novel classes of growth hormone-releasing peptide. Endocrinology 1995; 136: 5694-5699.
26. Hashimoto K, Koga M, Motomura T, Kasayama S, Kouhara H, Ohnishi T, Arita N, Hayakawa T, Sato B, Kishimoto T. Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. J Clin Endocrinol Metab 1995; 80: 2933-2939.
27. Tang J, Lagacé G, Castagné J, Collu R. Identification of human growth hormone-releasing hormone receptor splicing variants. J Clin Endocrinol Metab 1995; 80: 2381-2387.
28. Bennett PA, Thomas GB, Howard AD, Feighner SD. Van der Ploeg LHT, Smith RG, Robinson ICAF. Hypothalamic growth-hormone secretagogue receptor (GHS-R) expression is regulated by growth hormone in the rat. Endocrinology 1997; 138: 4552-4557.
29. Renner U, Brockmeier S, Strasburger CJ, Lange M, Schopohl J, Müller OA, Werder KV, Stalla GK. Growth hormone (GH)-releasing peptide stimulation of GH release from human somatotroph adenoma cells: interaction with GH-releasing hormone, thyrotropin-releasing hormone, and octreotide. J Clin Endocrinol Metab 1994; 78: 1090-1096.
30. Ong H, McNicoll N, Escher E, Collu R, Deghenghi R, Locatelli V, Ghigo E, Mucciolo G, Boghen M, Nilsson M. Identification of a pituitary growth hormone-releasing Peptide (GHRP) receptor subtype by photo-affinity labelling. Endocrinology 1998; 139: 432-434.
31. Korbonits M, Jacobs RA, Aylwin SJB, Burrin JM, Dahia PLM, Monson JP, Honegger J, Fahlbush R, Trainer PJ, Chew SL, Besser GM, Grossman AB. Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors. J Clin Endocrinol Metab 1998; 83: 3624-3630.
32. Blake AD. Smith RG. Desensitization studies using perifused rat pituitary cells show that growth hormone-releasing hormone and His-D-Trp-AlaTrp-D-Phe-Lys-NH2 stimulate growth hormone release through distinct receptor sites. J Endocrinol 1991; 129: 11-19.
33. Wu D, Chen C, Zhang J, Katoh K, Clarke I. Effects in vitro of new growth hormone releasing peptide (GHRP-1) on growth hormone secre-tion from ovine pituitary cells in primary culture. J Neuroendocrinol 1994; 6: 185-190.
34. Cheng J, Wu T-J, Butler B, Cheng K. Growth hormone releasing peptides: a comparison of the growth hormone releasing activities of GHRP-2 and GHRP-6 in rat primary pituitary cells. Life Sci 1997; 60: 1385-1392.
35. DeBell WK, Pezzoli SS, Thorner MO. Growth hormone (GH) secretion during continuous infusion of GH-releasing peptide: partial response attenuation. J Clin Endocrinol Metab 1991; 72: 1312-1316.
36. Huhn WC, Hartman ML, Pezzoli SS, Thorner MO. Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus. J Clin Endocrinol Metab 1993; 76: 1202-1208.
37. Gelato MC, Oldfield E, Loriaux L, Marriam GR. Pulsatile Growth Hormone secretion in patients with acromegaly and normal men: the effects of growth hormone-releasing hormone infusion. J Clin Endocrinol Metab 1990; 71: 585-590.
38. Spada A, Elahi FR, Arosio M, Sartotorio A, Guglielmino L, Vallar L, Faglia G. Lack of desensitization of adenomatous somatotrophs to growth-hormone releasing hormone in acromegaly. J Clin Endocrinol Metab 1987; 64: 585-591.
39. Ghigo E, Arvat E, Ramunni J, Colao A, Gianotti L, Deghenghi R, Lombardi G, Camanni. Adrenocorticotropin- and cortisol-releasing effect of Hexarelin, a synthetic growth hormone-realeasing peptide, in normal subjects and patients with cushing's syndrome. J Clin Endocrinol Metab 1997; 82: 2439-2444.
40. Shimon I, Yan X, Melmed S. Human fetal pituitary expresses functional growth hormone-releasing peptide receptors. J Clin Endocrinol Metab 1998; 83: 174-178.
41. Friebos R-M, Murck H, Maier P, Schier T, Holsboer F. Steiger A. Growth hormone releasing peptide-6 stimulates sleep, growth hormone, ACTH and Cortisol release in normal man. Neuroendocrinohgy 1995; 61: 584-589.
42. Hickey GJ, Drisko L, Faidley T, Chang C, Anderson LL, Nicolich S, McGuire L, Rickes E, Krupa D, Feeney W, Friscino B, Cunningham P, Frazier E, Chen H, Laroque P, Smith RG. Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692 585. J Endocrinol 1996; 148: 371-380.
43. Thomas GB, Fairhall KM, Robinson ICAF. Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats. Endocrinology 1997; 138: 1585-1591.