Impaired leptin signal transduction with age-related obesity

Neuropharmacology

Volumn 39, Issue 10, 2000, Pages 1872-1879

  Scarpace, Philip J ^a,b   Matheny, Michael ^a,b   Shek, Eugene W ^a,b  

^a Education and Clinical Center   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

F344xBN rats; Hypothalamus; STAT3

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; STAT1 PROTEIN; STAT3 PROTEIN;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; ENERGY EXPENDITURE; FOOD INTAKE; HYPOTHALAMUS; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

AGING; ANIMALS; BINDING, COMPETITIVE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOTHALAMUS; LEPTIN; MALE; MICE; OBESITY; PHOSPHORYLATION; RATS; RATS, INBRED BN; RATS, INBRED F344; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TRANS-ACTIVATORS;

EID: 0034085453     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00014-9     Document Type: Article

References (26)

1. Billington C.J., Briggs J.E., Grace M., Levine A.S. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. American Journal of Physiology. 260:1991;R321-R327.
2. Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. Journal of Biological Chemistry. 272(51):1997;32686-32695.
3. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry. 72:1976;248-254.
4. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
5. Caro J.F., Kolaczynski J.W., Nyce M.R., Ohannesian J.P., Opentanova I., Goldman W.H., Lynn R.B., Zhang P.L., Sinha M.K., Considine R.V. Decreased cerebrospinal-fluid/serum leptin ratio in obesity; a possible mechanism for leptin resistance. Lancet. 348:1996;159-161.
6. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine. 334:1996;292-295.
7. Darnell J.E. Jr. Stats and gene regulation. Science. 277:1997;1630-1635.
8. Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M.H., Skoda R.C. Defective STAT signaling by the leptin receptor in diabetic mice. Proceedings of the National Academy of Science. 93:1996;6231-6235.
9. Halaas J.L., Boozer C., Blair-West J., Fidahusein N., Denton D.A., Friedman J.M. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proceedings of the National Academy of Science. 94:1997;8878-8883.
10. Levine A.S., Morley J.E. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides. 5:1984;1025-1029.
11. Li H., Matheny M., Nicolson M., Tümer N., Scarpace P.J. Leptin gene expression increases with age independent of increasing adiposity in rats. Diabetes. 46:1997;2035-2039.
12. McCowen K., Chow J., Smith R.J. Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology. 139:1998;4442-4447.
13. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Letters. 387:1996;113-116.
14. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. Journal of Neuroendocrinology. 8:1996;733-735.
15. Pelleymounter M., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
16. Scarpace P.J., Matheny M., Borst S., Tümer N. Thermoregulation with age: role of thermogenesis and uncoupling protein expression in brown adipose tissue. Proceedings of the Society of Biological Medicine. 205:1994;154-161.
17. Scarpace P.J., Matheny M., Pollock B.H., Tümer N. Leptin increases uncoupling protein expression and energy expenditure. American Journal of Physiology. 273:1997;E226-230.
18. Scarpace P.J., Matheny M., Moore R.L., Tümer N. Impaired leptin responsiveness in aged rats. Diabetes. 49:2000;431-435.
19. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. Journal of Clinical Investigation. 98:1996;1101-1106.
20. Schwartz R.S. Obesity in the elderly. Bray G.A., Bouchard C., James W.P.T. Handbook of Obesity. 1998;103-114 Marcel Dekker, New York.
21. Tarttaglia L.A. The leptin receptor. Journal of Biological Chemistry. 272:1997;6093-6096.
22. Tümer N., Scarpace P.J., Baker H.V., LaRochelle J.S. AP-1 transcription factor binding activity in the adrenal medulla and hypothalamus with age and cold exposure. Neuropharmacology. 36:1997;1065-1069.
23. Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E. Jr., Stoffel M., Friedman J.M. Leptin activation of Stat3 in the hypoythalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics. 14:1996;95-97.
24. Van Heek M., Compton D.S., France C.F., Tedesco R.P., Fawzi A.B., Graziano M.P., Sybertz E.J., Strader C.D., Davis H.R. Jr. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. Journal of Clinical Investigation. 99:1997;385-390.
25. Widdowson P.S., Upton R., Buckingham R., Arch J., Williams G. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes. 46:1997;1782-1785.
26. Yamashita T., Murakami T., Otani S., Kuwajima M., Shima K. Leptin receptor signal transduction: OBRa and OBRb of fa Type. Biochemistry and Biophysics Research Communications. 246:1998;752-759.