Leptin gene expression increases with age independent of increasing adiposity in rats

Diabetes

Volumn 46, Issue 12, 1997, Pages 2035-2039

  Li, Hua ^a   Matheny, Michael ^a   Nicolson, Margery ^b   Tümer, Nihal ^a   Scarpace, Philip J ^a,c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b AMGEN INC   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; GENE EXPRESSION REGULATION; NONHUMAN; NUTRITIONAL DISORDER; OBESITY; PRIORITY JOURNAL; RAT; SEXUAL MATURATION; WEIGHT GAIN;

EID: 0030856122     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.12.2035     Document Type: Article

References (26)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-132, 1994
2. Brozek J: Changes in body composition in man during maturity and their nutritional implications. Fed Proc 11:784-793, 1952
3. Epstein FH, Higgins M: Epidemiology of obesity. In Obesity. Bjorntorp P, Brodoff BN, Eds. Philadelphia, J.B. Lippincott, 1992, p. 330-342
4. Malina RM: Quantification of fat, muscle and bone in man. Clin Orthop 65:9-38, 1969
5. Millar WJ, Stephens T: The prevalence of overweight and obesity in Britain, Canada, and the United States. Am J Public Health 77:38-41, 1987
6. Meier CA: Advances in the understanding of the molecular basis of obesity. Eur J Endocrinol 133:761-763, 1995
7. Scarpace PJ, Matheny M: Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol 273:E226-E230, 1997
8. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
9. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
10. Pelleymounter M, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
11. Masoro EJ: Rats as models for the study of obesity. Exp Aging Res 6:261-270, 1980
12. Sprott RL, Austad SN: Animals models for aging research. In Handbook of the Biology of Aging. Schneider EL, Rowe JW, Eds. San Diego, CA, Academic Press, 1996, p. 3-23
13. Scarpace PJ, Matheny M, Borst S, Tümer N: Thermoregulation with age: role of thermogenesis and uncoupling protein expression in brown adipose tissue. Proc Soc Exp Biol Med 205:154-161, 1994
14. Taylor BA, Phillips SJ: Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics 34:389-398, 1996
15. Bernardis LL, Luboshitsky R, Bellinger LL, McEwen G: Nutritional studies in the weaning rat with normophagic hypothalamic obesity. J Nutr 112:1441-1455, 1982
16. Lee MO: Determination of the surface area of the white rat with its application to the expression of metabolic results. Am J Physiol 89:24-31, 1929
17. Bernardis L. Patterson BD: Correlation between "Lee Index" and carcass fat content in weaning and adult female rats with hypothalamic lesions. J Endocrinol 40:527-528, 1968
18. Hotta K, Gustafson A, Ortmeyer HK, Bodkin NL, Nicolson MA, Hansen BC: Regulation of obese (ob) mRNA and plasma leptin levels in rhesus monkeys. J Biol Chem 271:25327-25331, 1996
19. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156-159, 1987
20. Trayhurn P, Duncan JS, Rayner DV: Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J 311:729-733, 1995
21. Kozak L, Britton PJ, Kozak UC, Wells JM: The mitochondrial uncoupling protein gene. J Biol Chem 263:12272-12277, 1988
22. Klein S, Coppack SW, Mohamed Ali V, Landt M: Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45:984-987, 1996
23. McGregor GP, Desaga JF, Ehlenz K, Fischer A, Heese F, Hegele A, Lammer C, Peiser C, Lang RE: Radioimmunological measurement of leptin in plasma of obese and diabetic human subjects. Endocrinology 137:1501-1504, 1996
24. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D Jr: Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 2:589-593, 1996
25. Maffei M, Hallas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1160, 1995
26. Ostlund RE, Yang JW, Klein S, Gingerich R: Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic convariates. J Clin Endocrinol Metab 81:3909-3913, 1996