TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the Proteasome

Chemistry and Biology

Volumn 13, Issue 6, 2006, Pages 607-614

  Groll, Michael ^a   Götz, Marion ^b   Kaiser, Markus ^b   Weyher, Elisabeth ^b   Moroder, Luis ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

CHEMBIO; PROTEINS

Indexed keywords

CROSS LINKING REAGENT; CYCLOPEPTIDE; DIPHENYL ETHER DERIVATIVE; PROTEASOME; PROTEINASE INHIBITOR; TMC 95A; TMC-95A; TRYPSIN; TRYPSIN INHIBITOR;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYSIS; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; PHENYL ETHERS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRYPSIN; TRYPSIN INHIBITORS;

EID: 33745187107     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2006.04.005     Document Type: Article

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