An Antigenic Peptide Produced by Peptide Splicing in the Proteasome

Science

Volumn 304, Issue 5670, 2004, Pages 587-590

  Vigneron, Nathalie ^a   Stroobant, Vincent ^a   Chapiro, Jacques ^a   Ooms, Annie ^b   Degiovanni, Gérard ^b   Morel, Sandra ^a,c   Van Der Bruggen, Pierre ^a   Boon, Thierry ^a   Van Den Eynde, Benoît J ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c GSK   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIGENS; BIOCOMPATIBILITY; CELLS; POLYPEPTIDES;

GLYCOPROTEINS; PROTEASOMES;

ENZYME KINETICS;

AMINO ACID; GLYCOPROTEIN GP 100; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME;

MEDICINE;

AMINO ACID SUBSTITUTION; ANTIGEN RECOGNITION; ANTIGENICITY; ARTICLE; CYTOTOXIC T LYMPHOCYTE; INTERFERON PRODUCTION; LYMPHOCYTE ACTIVATION; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; CELL LINE, TUMOR; COS CELLS; CYSTEINE ENDOPEPTIDASES; ELECTROPORATION; HLA-A ANTIGENS; HUMANS; INTERFERON TYPE II; MELANOMA; MEMBRANE GLYCOPROTEINS; MODELS, CHEMICAL; MULTIENZYME COMPLEXES; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PRECURSORS; PROTEIN SPLICING; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 2142644458     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1095522     Document Type: Article

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17. We thank P. Coulie for suggestions, N. Demotte for help with peptide electroporation, S. Claverol for evaluating the purity of proteasome preparations, and E. Van Schaftingen, L. Hue, D. Godelaine, J. Berthet, and E. Warren for critical reading of the manuscript. N.V. and J.C. were supported by a Télévie fellowship from the Fonds National de la Recherche Scientifique (FNRS), Belgium. This work was supported by grants from the FNRS and the Fédération Belge contre le Cancer (Belgium).