Binding mode of TMC-95A analogues to eukaryotic 20S proteasome

ChemBioChem

Volumn 5, Issue 9, 2004, Pages 1256-1266

  Kaiser, Markus ^a   Groll, Michael ^b   Siciliano, Carlo ^a   Assfalg Machleidt, Irmgard ^b   Weyher, Elisabeth ^a   Kohno, Jun ^c   Milbradt, Alexander G ^a   Renner, Christian ^a   Huber, Robert ^a   Moroder, Luis ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

20S proteasome; Binding affinities; Conformation analysis; Enzyme inhibitors; X ray diffraction

Indexed keywords

20S PROTEASOME; CHYMOTRYPSIN; FUNCTIONAL GROUP; NATURAL PRODUCT; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROP 1 ENYL DERIVATIVE; PROTEASOME; PROTEASOME INHIBITOR; TMC 95A DERIVATIVE; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; ENTROPY; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; EUKARYOTE; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY; YEAST;

EUKARYOTA;

EID: 4644259397     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200400096     Document Type: Article

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