Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids

Pharmaceutical Research

Volumn 20, Issue 6, 2003, Pages 864-872

  Ballard, Peter ^a   Leahy, David E ^b   Rowland, Malcolm ^c  

^a ASTRAZENECA   (United Kingdom)

^b CYPROTEX DISCOVERY LTD   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Barbiturate; In vitro in vivo correlation; Pharmacokinetics; Tissue distribution

Indexed keywords

5 N BUTYL 5 ETHYLBARBITURIC ACID; 5 N ETHYL 5 ETHYLBARBITURIC ACID; 5 N HEPTYL 5 ETHYLBARBITURIC ACID; 5 N HEXYL 5 ETHYLBARBITURIC ACID; 5 N METHYL 5 ETHYLBARBITURIC ACID; 5 N NONYL 5 ETHYLBARBITURIC ACID; 5 N OCTYL 5 ETHYLBARBITURIC ACID; 5 N PENTYL 5 ETHYLBARBITURIC ACID; 5 N PROPYL 5 ETHYLBARBITURIC ACID; AMOBARBITAL; BARBITURIC ACID DERIVATIVE; PHENOBARBITAL; THIOPENTAL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG INFUSION; DRUG TISSUE LEVEL; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; PRIORITY JOURNAL; RAT; STEADY STATE; TISSUE DISTRIBUTION;

ANIMALS; BARBITURATES; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HALF-LIFE; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; INFUSIONS, INTRAVENOUS; MALE; MASS SPECTROMETRY; MOLECULAR WEIGHT; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 0038662543     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023912318133     Document Type: Article

References (31)

1. H.-S. G. Chen and J. F. Gross. Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models. J. Pharmacokinet. Biopharm. 7:117-125 (1979).
2. K. B. Bischoff, R. L. Dedrick, and D. S. Zaharko. Preliminary model for methotrexate pharmacokinetics. J. Pharm. Sci. 59:149-154 (1970).
3. A. Benareggi and M. Rowland. Physiologic modeling of cyclosporin kinetics in rat and man. J. Pharmacokinet. Biopharm. 19:21-50 (1991).
4. J. L. Gabrielsson, L. K. Paalzow, and L. Nordstrom. A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat. J. Pharmacokinet. Biopharm. 12:149-165 (1984).
5. L. Granero, J. Chesa-Jimenez, V. Monserrat, M. Almela, M.-J. Gimeno, F. Torres-Molina, and J.-E. Peris-Ribera. Physiological pharmacokinetic model for ceftazidime disposition in the rat and its application to prediction of plasma concentration in humans. Eur. J. Pharm. Sci. 1:3-11 (1993).
6. Y. Igari, Y. Sugiyama, S. Awazu, and M. Hanano. Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital and thiopental in the rat. J. Pharmacokinet. Biopharm. 10:53-75 (1982).
7. G. E. Blakey, I. A. Nesterov, P. A. Arundel, L. J. Aarons, and M. Rowland. Quantitative structure pharmacokinetics relationships: 1. Development of a whole-body physiologically based model to characterize changes in pharmacokinetics across a homologous series of barbiturates in the rat. J. Pharmacokinet. Biopharm. 25:277-312 (1997).
8. R. Gubser, C. DiFransesco, and M. H. Bickel. Uptake of lipophilic model compounds into the isolated perfused rat epididymal adipose tissue. J. Pharmacol. Exp. Therap. 237:967-971 (1986).
9. C.-H. Chou, A. M. Evans, G. Fornasini, and M. Rowland. Relationship between lipophilicity and hepatic dispersion and distribution for a homologous series of barbiturates in the isolated perfused in situ rat liver. Drug Metab. Dispos. 21:933-938 (1993).
10. A. Heatherington and M. Rowland. Estimation of reference spaces in the perfused rat hindlimb. Eur. J. Pharm. Sci. 2:261-270 (1994).
11. M. H. Bickel, R. M. Raaflaub, M. Hellmuller, and E. J. Stauffer. Characterization of drug distribution and binding competition by two-chamber and multi-chamber distribution dialysis. J. Pharm. Sci. 76:68-74 (1987).
12. T. M. Ludden, L. S. Schanker, and R. C. Lanman. Binding of organic compounds to rat liver and lung. Drug Metab. Dispos. 4:8-16 (1976).
13. M. H. Bickel and J. W. Steele. Binding of basic and acidic drugs to rat tissue subcellular fractions. Chemico-Biol. Int. 8:151-162 (1974).
14. W. O. Berndt. Use of the tissue slice technique for evaluation of renal transport processes. Env. Health Persp. 15:73-88 (1976).
15. R. Drew and Z. H. Siddik. Effect of a specific 5HT uptake inhibitor (citalopram) on drug accumulation by rat lung slices. Pharmacol. 20:27-31 (1980).
16. C. Post, R. G. G. Andersson, A. Ryrfeldt, and E. Nilsson. Transport and binding of lidocaine by lung slices and perfused lung of rats. Acta Pharmacol. Tox. 43:156-163 (1978).
17. P. Ballard, P. A. Arundel, D. E. Leahy, and M. Rowland. Prediction of in vivo tissue distribution from in vitro data 2. Influence of albumin diffusion from tissue slices during an in vitro incubation on estimated tissue-to-unbound plasma partition coefficients (Kpu). Pharm. Res. 20:857-863.
18. P. Ballard, D. E. Leahy, and M. Rowland. Prediction of in vivo tissue distribution from in vitro data. 1. Experiments with markers of aqueous spaces. Pharm. Res. 17:660-663 (2000).
19. S. Toon and M. Rowland. Structure-pharmacokinetic relationships among the barbiturates in the rat. J. Pharmacol. Exp. Ther. 225:752-763 (1983).
20. G. Blakey. Whole body tissue distribution of the 5-alkyl-5-ethyl barbituric acids in the rat (preliminary results). PhD thesis, University of Manchester, 1993.
21. S. H. Steiner, M. J. Moor, and M. H. Bickel. Kinetics of distribution and adipose tissue storage as a function of lipophilicity and chemical structure. I. Barbiturates. Drug Metab. Dispos. 19:8-14 (1991).
22. C. B. Frederick, D. W. Potter, M. I. Chang-Mateu, and M. E. Andersen. A physiologically-based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment. Tox. Appl. Pharmacol. 114:246-260 (1992).
23. V. Fiserova-Bergerova, M. Tichy, and F. J. Di Carlo. Effects of biosolubility on pulmonary uptake and disposition of gases and vapors of lipophilic chemicals. Drug Metab. Rev. 15:1033-1070 (1984).
24. J. H. Lin, Y. Sugiyama, S. Awazu, and M. Hanano. In vitro and in vivo evaluation of the tissue blood partition coefficient for physiological pharmacokinetic models. J. Pharmacokinet. Biopharm. 10:637-647 (1982).
25. p,f) of quinidine in rats. J. Pharm. Pharmacol. 36:340-342 (1984).
26. G. Schuhmann, B. Fichtl, and H. Kurz. Prediction of drug distribution in vivo on the basis of in vitro binding data. Biopharm. Drug Dispos. 8:73-86 (1987).
27. P. Poulin and F.-P. Theil. Prediction of pharmacokinetics prior to in vivo studies. I. Mechanism-based prediction of volume of distribution. J. Pharm. Sci. 91:129-156 (2002).
28. P. Poulin and F.-P. Theil. Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition. J. Pharm. Sci. 91:1358-1370 (2002).
29. I. Nestorov, L. J. Aarons, and M. Rowland. Quantitative structure-pharmacokinetics relationships: II. A mechanistically based model to evaluate the relationship between tissue distribution parameters and compound lipophilicity. J. Pharmacokinet. Biopharm. 26:521-545 (1998).
30. T. D. Yih and J. M. van Rossum. Ks values of some homologous series of barbiturates and the relationship with the lipophilicity and metabolic clearance. Biochem. Pharmacol. 26:2117-2120 (1977).
31. C. Hansch, A. R. Steward, S. M. Anderson, and D. Bentley. The parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics. J. Med. Chem. 11:1-11 (1967).