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Volumn 45, Issue 23, 2006, Pages 7334-7340

Modulation of human immunodeficiency virus type 1 synergistic inhibition by reverse transcriptase mutations

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOCHEMISTRY; CELL CULTURE; PHOSPHATES; VIRUSES;

EID: 33745032037     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052362v     Document Type: Article
Times cited : (21)

References (56)
  • 1
    • 0027986621 scopus 로고
    • Issues in combination antiretroviral therapy: A review
    • discussion S35-S37
    • Hammer, S. M., Kassler, H. A., and Saag, M. S. (1994) Issues in combination antiretroviral therapy: a review, JAIDS, J. Acquired Immune Defic. Syndr. 7 (Suppl. 2), S24-S35; discussion S35-S37.
    • (1994) JAIDS, J. Acquired Immune Defic. Syndr. , vol.7 , Issue.SUPPL. 2
    • Hammer, S.M.1    Kassler, H.A.2    Saag, M.S.3
  • 2
    • 0026523623 scopus 로고
    • HIV inhibitors targeted at the reverse transcriptase
    • De Clercq, E. (1992) HIV inhibitors targeted at the reverse transcriptase, AIDS Res. Hum. Retroviruses 8, 119-134.
    • (1992) AIDS Res. Hum. Retroviruses , vol.8 , pp. 119-134
    • De Clercq, E.1
  • 3
    • 0025912292 scopus 로고
    • Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo
    • Goody, R. S., Muller, B., and Restle, T. (1991) Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo, FEBS Lett. 291, 1-5.
    • (1991) FEBS Lett. , vol.291 , pp. 1-5
    • Goody, R.S.1    Muller, B.2    Restle, T.3
  • 4
    • 0028172345 scopus 로고
    • Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance
    • Tantillo, C., Ding, J., Jacobo-Molina, A., Nanni, R. G., Boyer, P. L., Hughes, S. H., Pauwels, R., Andries, K., Janssen, P. A., and Arnold, E. (1994) Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance, J. Mol. Biol. 243, 369-387.
    • (1994) J. Mol. Biol. , vol.243 , pp. 369-387
    • Tantillo, C.1    Ding, J.2    Jacobo-Molina, A.3    Nanni, R.G.4    Boyer, P.L.5    Hughes, S.H.6    Pauwels, R.7    Andries, K.8    Janssen, P.A.9    Arnold, E.10
  • 5
    • 0026693137 scopus 로고
    • Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
    • Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., and Steitz, T. A. (1992) Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor, Science 256, 1783-1790.
    • (1992) Science , vol.256 , pp. 1783-1790
    • Kohlstaedt, L.A.1    Wang, J.2    Friedman, J.M.3    Rice, P.A.4    Steitz, T.A.5
  • 6
    • 0028925773 scopus 로고
    • Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
    • Spence, R. A., Kati, W. M., Anderson, K. S., and Johnson, K. A. (1995) Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors, Science 267, 988-993.
    • (1995) Science , vol.267 , pp. 988-993
    • Spence, R.A.1    Kati, W.M.2    Anderson, K.S.3    Johnson, K.A.4
  • 7
    • 0029150042 scopus 로고
    • Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors
    • Rittinger, K., Divita, G., and Goody, R. S. (1995) Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors, Proc. Natl. Acad. Sci. U.S.A. 92, 8046-8049.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 8046-8049
    • Rittinger, K.1    Divita, G.2    Goody, R.S.3
  • 9
    • 0033987078 scopus 로고    scopus 로고
    • Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: An equivalent incorporation efficiency relative to the natural substrate dTTP
    • Vaccaro, J. A., Parnell, K. M., Terezakis, S. A., and Anderson, K. S. (2000) Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP, Antimicrob. Agents Chemother. 44, 217-221.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 217-221
    • Vaccaro, J.A.1    Parnell, K.M.2    Terezakis, S.A.3    Anderson, K.S.4
  • 10
    • 0032491178 scopus 로고    scopus 로고
    • Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3′-azido-3′- deoxythymidine (AZT) resistance
    • Vaccaro, J. A., and Anderson, K. S. (1998) Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3′-azido-3′-deoxythymidine (AZT) resistance, Biochemistry 37, 14189-14194.
    • (1998) Biochemistry , vol.37 , pp. 14189-14194
    • Vaccaro, J.A.1    Anderson, K.S.2
  • 11
    • 0034852589 scopus 로고    scopus 로고
    • Mechanistic studies to understand the inhibition of wild type and mutant HIV-1 reverse transcriptase by Carbovir-triphosphate
    • Ray, A. S., and Anderson, K. S. (2001) Mechanistic studies to understand the inhibition of wild type and mutant HIV-1 reverse transcriptase by Carbovir-triphosphate, Nucleosides, Nucleotides Nucleic Acids 20, 1247-1250.
    • (2001) Nucleosides, Nucleotides Nucleic Acids , vol.20 , pp. 1247-1250
    • Ray, A.S.1    Anderson, K.S.2
  • 12
    • 0037161286 scopus 로고    scopus 로고
    • Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate
    • Ray, A. S., Yang, Z., Shi, J., Hobbs, A., Schinazi, R. F., Chu, C. K., and Anderson, K. S. (2002) Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate, Biochemistry 41, 5150-5162.
    • (2002) Biochemistry , vol.41 , pp. 5150-5162
    • Ray, A.S.1    Yang, Z.2    Shi, J.3    Hobbs, A.4    Schinazi, R.F.5    Chu, C.K.6    Anderson, K.S.7
  • 13
    • 0033587620 scopus 로고    scopus 로고
    • Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase
    • Feng, J. Y., and Anderson, K. S. (1999) Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase, Biochemistry 38, 9440-9448.
    • (1999) Biochemistry , vol.38 , pp. 9440-9448
    • Feng, J.Y.1    Anderson, K.S.2
  • 14
    • 0043239160 scopus 로고    scopus 로고
    • Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase
    • Ray, A. S., Schinazi, R. F., Murakami, E., Basavapathruni, A., Shi, J., Zorca, S. M., Chu, C. K., and Anderson, K. S. (2003) Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase, Antiviral Chem. Chemother. 14, 115-125.
    • (2003) Antiviral Chem. Chemother. , vol.14 , pp. 115-125
    • Ray, A.S.1    Schinazi, R.F.2    Murakami, E.3    Basavapathruni, A.4    Shi, J.5    Zorca, S.M.6    Chu, C.K.7    Anderson, K.S.8
  • 15
    • 0036233261 scopus 로고    scopus 로고
    • Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase
    • Meyer, P. R., Matsuura, S. E., Tolun, A. A., Pfeifer, I., So, A. G., Mellors, J. W., and Scott, W. A. (2002) Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase, Antimicrob. Agents Chemother. 46, 1540-1545.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1540-1545
    • Meyer, P.R.1    Matsuura, S.E.2    Tolun, A.A.3    Pfeifer, I.4    So, A.G.5    Mellors, J.W.6    Scott, W.A.7
  • 16
    • 0034425841 scopus 로고    scopus 로고
    • Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2′-deoxynucleoside triphosphates
    • Meyer, P. R., Matsuura, S. E., Schinazi, R. F., So, A. G., and Scott, W. A. (2000) Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2′-deoxynucleoside triphosphates, Antimicrob. Agents Chemother. 44, 3465-3472.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 3465-3472
    • Meyer, P.R.1    Matsuura, S.E.2    Schinazi, R.F.3    So, A.G.4    Scott, W.A.5
  • 17
    • 0033165851 scopus 로고    scopus 로고
    • A mechanism of AZT resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
    • Meyer, P. R., Matsuura, S. E., Mian, A. M., So, A. G., and Scott, W. A. (1999) A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase, Mol. Cell 4, 35-43.
    • (1999) Mol. Cell , vol.4 , pp. 35-43
    • Meyer, P.R.1    Matsuura, S.E.2    Mian, A.M.3    So, A.G.4    Scott, W.A.5
  • 18
    • 0032506228 scopus 로고    scopus 로고
    • Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism
    • Meyer, P. R., Matsuura, S. E., So, A. G., and Scott, W. A. (1998) Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism, Proc. Natl. Acad. Sci. U.S.A. 95, 13471-13476.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13471-13476
    • Meyer, P.R.1    Matsuura, S.E.2    So, A.G.3    Scott, W.A.4
  • 19
    • 0042347690 scopus 로고    scopus 로고
    • Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis
    • Ray, A. S., Murakami, E., Basavapathruni, A., Vaccaro, J. A., Ulrich, D., Chu, C. K., Schinazi, R. F., and Anderson, K. S. (2003) Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis, Biochemistry 42, 8831-8841.
    • (2003) Biochemistry , vol.42 , pp. 8831-8841
    • Ray, A.S.1    Murakami, E.2    Basavapathruni, A.3    Vaccaro, J.A.4    Ulrich, D.5    Chu, C.K.6    Schinazi, R.F.7    Anderson, K.S.8
  • 20
    • 1342325435 scopus 로고    scopus 로고
    • Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs
    • Basavapathruni, A., Bailey, C. M., and Anderson, K. S. (2004) Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs, J. Biol. Chem. 279, 6221-6224.
    • (2004) J. Biol. Chem. , vol.279 , pp. 6221-6224
    • Basavapathruni, A.1    Bailey, C.M.2    Anderson, K.S.3
  • 21
    • 0029670612 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors
    • Spence, R. A., Anderson, K. S., and Johnson, K. A. (1996) HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors, Biochemistry 35, 1054-1063.
    • (1996) Biochemistry , vol.35 , pp. 1054-1063
    • Spence, R.A.1    Anderson, K.S.2    Johnson, K.A.3
  • 22
    • 0000342562 scopus 로고    scopus 로고
    • Mutations in retroviral genes associated with drug resistance
    • Schinazi, R. F., Larder, B. A., and Mellors, J. W. (1997) Mutations in retroviral genes associated with drug resistance, Int. Antiviral News 5, 129-135.
    • (1997) Int. Antiviral News , vol.5 , pp. 129-135
    • Schinazi, R.F.1    Larder, B.A.2    Mellors, J.W.3
  • 23
    • 0034435564 scopus 로고    scopus 로고
    • Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase
    • Ren, J., Milton, J., Weaver, K. L., Short, S. A., Stuart, D. I., and Stammers, D. K. (2000) Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase, Struct. Folding Des. 8, 1089-1094.
    • (2000) Struct. Folding Des. , vol.8 , pp. 1089-1094
    • Ren, J.1    Milton, J.2    Weaver, K.L.3    Short, S.A.4    Stuart, D.I.5    Stammers, D.K.6
  • 25
    • 2942565660 scopus 로고    scopus 로고
    • Structural and biochemical effects of human immunodeficiency virus mutants resistant to nonnucleoside reverse transcriptase inhibitors
    • Domaoal, R. A., and Demeter, L. M. (2004) Structural and biochemical effects of human immunodeficiency virus mutants resistant to nonnucleoside reverse transcriptase inhibitors, Int. J. Biochem. Cell Biol. 36, 1735-1751.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 1735-1751
    • Domaoal, R.A.1    Demeter, L.M.2
  • 26
    • 0036090544 scopus 로고    scopus 로고
    • Potency of nonnucleoside reverse transcriptase inhibitors (NNRTIs) used in combination with other human immunodeficiency virus NNRTIs, NRTIs, or protease inhibitors
    • King, R. W., Klabe, R. M., Reid, C. D., and Erickson-Viitanen, S. K. (2002) Potency of nonnucleoside reverse transcriptase inhibitors (NNRTIs) used in combination with other human immunodeficiency virus NNRTIs, NRTIs, or protease inhibitors, Antimicrob. Agents Chemother. 46, 1640-1646.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1640-1646
    • King, R.W.1    Klabe, R.M.2    Reid, C.D.3    Erickson-Viitanen, S.K.4
  • 27
    • 0032437454 scopus 로고    scopus 로고
    • The role of nonnucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
    • De Clercq, E. (1998) The role of nonnucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection, Antiviral Res. 38, 153-179.
    • (1998) Antiviral Res. , vol.38 , pp. 153-179
    • De Clercq, E.1
  • 28
    • 0142242148 scopus 로고    scopus 로고
    • Nonnucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3′-Azido-3′-deoxythymidine (AZT)-resistant polymerase to AZT-5′-triphosphate
    • Odriozola, L., Cruchaga, C., Andreola, M., Dolle, V., Nguyen, C. H., Tarrago-Litvak, L., Perez-Mediavilla, A., and Martinez-Irujo, J. J. (2003) Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase Inhibit Phosphorolysis and Resensitize the 3′-Azido-3′-deoxythymidine (AZT)-resistant Polymerase to AZT-5′-triphosphate, J. Biol. Chem. 278, 42710-42716.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42710-42716
    • Odriozola, L.1    Cruchaga, C.2    Andreola, M.3    Dolle, V.4    Nguyen, C.H.5    Tarrago-Litvak, L.6    Perez-Mediavilla, A.7    Martinez-Irujo, J.J.8
  • 29
    • 14644441681 scopus 로고    scopus 로고
    • Inhibition of phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3′-azido-3′- deoxythymidine with nonnucleoside inhibitors
    • Cruchaga, C., Odriozola, L., Andreola, M., Tarrago-Litvak, L., and Martinez-Irujo, J. J. (2005) Inhibition of phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3′-azido-3′-deoxythymidine with nonnucleoside inhibitors, Biochemistry 44, 3535-3546.
    • (2005) Biochemistry , vol.44 , pp. 3535-3546
    • Cruchaga, C.1    Odriozola, L.2    Andreola, M.3    Tarrago-Litvak, L.4    Martinez-Irujo, J.J.5
  • 30
    • 0032992656 scopus 로고    scopus 로고
    • The thiocarboxanilide nonnucleoside inhibitor UC781 restores antiviral activity of 3′-azido-3′-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus type 1
    • Borkow, G., Arion, D., Wainberg, M. A., and Parniak, M. A. (1999) The thiocarboxanilide nonnucleoside inhibitor UC781 restores antiviral activity of 3′-azido-3′-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus type 1, Antimicrob. Agents Chemother. 43, 259-263.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 259-263
    • Borkow, G.1    Arion, D.2    Wainberg, M.A.3    Parniak, M.A.4
  • 31
    • 0030703245 scopus 로고    scopus 로고
    • Pre-steady-state kinetic characterization of wild type and 3′-azido-3′-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: Implication of RNA directed DNA polymerization in the mechanism of AZT resistance
    • Kerr, S. G., and Anderson, K. S. (1997) Pre-steady-state kinetic characterization of wild type and 3′-azido-3′-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance, Biochemistry 36, 14064-14070.
    • (1997) Biochemistry , vol.36 , pp. 14064-14070
    • Kerr, S.G.1    Anderson, K.S.2
  • 33
    • 0141815647 scopus 로고    scopus 로고
    • Characterization of novel reverse transcriptase and other RNA-associatedpar catalytic activities by human DNA polymerase gamma: Importance in mitochondrial DNA replication
    • Murakami, E., Feng, J. Y., Lee, H., Hanes, J., Johnson, K. A., and Anderson, K. S. (2003) Characterization of novel reverse transcriptase and other RNA-associatedpar catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication, J. Biol. Chem. 278, 36403-36409.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36403-36409
    • Murakami, E.1    Feng, J.Y.2    Lee, H.3    Hanes, J.4    Johnson, K.A.5    Anderson, K.S.6
  • 34
    • 0029867822 scopus 로고    scopus 로고
    • Drug combinations and effect parameters of zidovudine, stavudine, and nevirapine in standardized drug-sensitive and resistant HIV type 1 strains
    • Zhu, Q. Y., Scarborough, A., Polsky, B., and Chou, T. C. (1996) Drug combinations and effect parameters of zidovudine, stavudine, and nevirapine in standardized drug-sensitive and resistant HIV type 1 strains, AIDS Res. Hum. Retroviruses 12, 507-517.
    • (1996) AIDS Res. Hum. Retroviruses , vol.12 , pp. 507-517
    • Zhu, Q.Y.1    Scarborough, A.2    Polsky, B.3    Chou, T.C.4
  • 35
    • 0035080175 scopus 로고    scopus 로고
    • Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogues
    • Maga, G., Hubscher, U., Pregnolato, M., Ubiali, D., Gosselin, G., and Spadari, S. (2001) Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogues, Antimicrob. Agents Chemother. 45, 1192-1200.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1192-1200
    • Maga, G.1    Hubscher, U.2    Pregnolato, M.3    Ubiali, D.4    Gosselin, G.5    Spadari, S.6
  • 37
    • 0034786988 scopus 로고    scopus 로고
    • Resistance profile and cross-resistance of HIV-1 among patients failing a nonnucleoside reverse transcriptase inhibitor-containing regimen
    • Delaugerre, C., Rohban, R., Simon, A., Mouroux, M., Tricot, C., Agher, R., Huraux, J. M., Katlama, C., and Calvez, V. (2001) Resistance profile and cross-resistance of HIV-1 among patients failing a nonnucleoside reverse transcriptase inhibitor-containing regimen, J. Med. Virol. 65, 445-448.
    • (2001) J. Med. Virol. , vol.65 , pp. 445-448
    • Delaugerre, C.1    Rohban, R.2    Simon, A.3    Mouroux, M.4    Tricot, C.5    Agher, R.6    Huraux, J.M.7    Katlama, C.8    Calvez, V.9
  • 38
    • 0142040125 scopus 로고    scopus 로고
    • The Y181C substitution in 3′-azido-3′-deoxythymidine- resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 3′-azido-3′-deoxythymidine 5′-monophosphate-terminated primer
    • Selmi, B., Deval, J., Alvarez, K., Boretto, J., Sarfati, S., Guerreiro, C., and Canard, B. (2003) The Y181C substitution in 3′-azido-3′- deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 3′-azido-3′- deoxythymidine 5′-monophosphate-terminated primer, J. Biol. Chem. 278, 40464-40472.
    • (2003) J. Biol. Chem. , vol.278 , pp. 40464-40472
    • Selmi, B.1    Deval, J.2    Alvarez, K.3    Boretto, J.4    Sarfati, S.5    Guerreiro, C.6    Canard, B.7
  • 39
    • 8544267978 scopus 로고    scopus 로고
    • Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase
    • Meyer, P. R., Smith, A. J., Matsuura, S. E., and Scott, W. A. (2004) Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase, J. Biol. Chem. 279, 45389-45398.
    • (2004) J. Biol. Chem. , vol.279 , pp. 45389-45398
    • Meyer, P.R.1    Smith, A.J.2    Matsuura, S.E.3    Scott, W.A.4
  • 43
    • 0034630305 scopus 로고    scopus 로고
    • Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors
    • Balzarini, J., De Clercq, E., Carbonez, A., Burt, V., and Kleim, J. P. (2000) Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors, AIDS Res. Hum. Retroviruses 16, 517-528.
    • (2000) AIDS Res. Hum. Retroviruses , vol.16 , pp. 517-528
    • Balzarini, J.1    De Clercq, E.2    Carbonez, A.3    Burt, V.4    Kleim, J.P.5
  • 44
    • 12144265244 scopus 로고    scopus 로고
    • Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs): Past, present, and future
    • De Clerc, Q. E. (2004) Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs): past, present, and future, Chem. Biodiversity 1, 44-64.
    • (2004) Chem. Biodiversity , vol.1 , pp. 44-64
    • De Clerc, Q.E.1
  • 45
    • 15444370583 scopus 로고    scopus 로고
    • New nonnucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections
    • Pauwels, R. (2004) New nonnucleoside reverse transcriptase inhibitors (NNRTIs) in development for the treatment of HIV infections, Curr. Opin. Pharmacol. 4, 437-446.
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 437-446
    • Pauwels, R.1
  • 52
    • 0037613579 scopus 로고    scopus 로고
    • Validation of a model for the complex of HIV-1 reverse transcriptase with nonnucleoside inhibitor TMC125
    • Udier-Blagovic, M., Tirado-Rives, J., and Jorgensen, W. L. (2003) Validation of a model for the complex of HIV-1 reverse transcriptase with nonnucleoside inhibitor TMC125, J. Am. Chem. Soc. 125, 6016-6017.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 6016-6017
    • Udier-Blagovic, M.1    Tirado-Rives, J.2    Jorgensen, W.L.3
  • 53
    • 0033619677 scopus 로고    scopus 로고
    • Initiation of minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase
    • Vaccaro, J. A., Singh, H. A., and Anderson, K. S. (1999) Initiation of minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase, Biochemistry 38, 15978-15985.
    • (1999) Biochemistry , vol.38 , pp. 15978-15985
    • Vaccaro, J.A.1    Singh, H.A.2    Anderson, K.S.3
  • 54
    • 11244293986 scopus 로고    scopus 로고
    • Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz
    • Crespan, E., Localelli, G. A., Cancio, R., Hubscher, U., Spadari, S., and Maga, G. (2005) Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz, Antimicrob. Agents Chemother. 49, 342-349.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 342-349
    • Crespan, E.1    Localelli, G.A.2    Cancio, R.3    Hubscher, U.4    Spadari, S.5    Maga, G.6


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