Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase Inhibit Phosphorolysis and Resensitize the 3′-Azido-3′-deoxythymidine (AZT)-resistant Polymerase to AZT-5′-triphosphate

Journal of Biological Chemistry

Volumn 278, Issue 43, 2003, Pages 42710-42716

  Odriozola, Leticia ^a   Cruchaga, Carlos ^a   Andréola, Marieline ^b   Dollé, Valérie ^c   Nguyen, Chi Hung ^c   Tarrago Litvak, Laura ^b   Pérez Mediavilla, Alberto ^a   Martínez Irujo, Juan J ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CONCENTRATION (PROCESS); ENZYMES;

MUTATIONS;

ENZYME INHIBITION;

3 DIMETHYLAMINO 4 (3,4 DIMETHYLBENZYL) 5 ETHYL 6 METHYLPYRIDIN 2(1H) ONE; ADENOSINE TRIPHOSPHATE; DIAZEPINE DERIVATIVE; NEVIRAPINE; PROTEIN P66; PYRIDINE DERIVATIVE; PYROPHOSPHATE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TETRAHYDROIMIDAZOBENZODIAZEPINONE; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE 5' PHOSPHATE; ZIDOVUDINE 5' TRIPHOSPHATE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHOSPHOROLYSIS; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANTI-HIV AGENTS; DIPHOSPHATES; DRUG RESISTANCE, VIRAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MUTATION, MISSENSE; NEVIRAPINE; PHOSPHORYLATION; PROTEIN SUBUNITS; REVERSE TRANSCRIPTASE INHIBITORS; THYMINE NUCLEOTIDES; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0142242148     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212673200     Document Type: Article

References (31)

1. Parker, W. B., White, E. L., Shaddix, S. C., Ross, L. J., Buckheit, R. W., Jr., Germany, J. M., Secrist, J. A. d., Vince, R., and Shannon, W. M. (1991) J. Biol. Chem. 266, 1754-1762
2. Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., and Steitz, T. A. (1992) Science 256, 1783-1790
3. Larder, B. A., and Kemp, S. D. (1989) Science 246, 1155-1158
4. Arion, D., Kaushik, N., McCormick, S., Borkow, G., and Parniak, M. A. (1998) Biochemistry 37, 15908-15917
5. Meyer, P. R., Matsuura, S. E., So, A. G., and Scott, W. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13471-13476
6. Meyer, P. R., Matsuura, S. E., Schinazi, R. F., So, A. G., and Scott, W. A. (2000) Antimicrob. Agents Chemother. 44, 3465-3472
7. Boyer, P. L., Sarafianos, S. G., Arnold, E., and Hughes, S. H. (2001) J. Virol. 75, 4832-4842
8. Borkow, G., Arion, D., Wainberg, M. A., and Parniak, M. A. (1999) Antimicrob. Agents Chemother. 43, 259-263
9. Merluzzi, V. J., Hargrave, K. D., Labadia, M., Grozinger, K., Skoog, M., Wu, J. C., Shih, C. K., Eckner, K., Hattox, S., Adams, J., Rosehthal, A. S., Faanes, R., Eckner, R. J., Koup, R. A., and Sullivan, J. L. (1990) Science 250, 1411-1413
10. Pauwels, R., Andries, K., Debyser, Z., Kukla, M., Schols, D., Desmyter, J., De Clercq, E., and Janssen, P. A. (1992) Biochem. Soc. Trans. 20, 509-512
11. Dolle, V., Nguyen, C. H., Legraverend, M., Aubertin, A. M., Kirn, A., Andreola, M. L., Ventura, M., Tarrago-Litvak, L., and Bisagni, E. (2000) J. Med. Chem. 43, 3949-3962
12. Spence, R. A., Kati, W. M., Anderson, K. S., and Johnson, K. A. (1995) Science 267, 988-993
13. Richman, D. D. (1991) AIDS 5, S189-S194
14. Baba, M., Shigeta, S., Yuasa, S., Takashima, H., Sekiya, K., Ubasawa, M., Tanaka, H., Miyasaka, T., Walker, R. T., and De Clercq, E. (1994) Antimicrob. Agents Chemother. 38, 688-692
15. Buckheit, R. W., Jr., Fliakas Boltz, V., Decker, W. D., Roberson, J. L., Pyle, C. A., White, E. L., Bowdon, B. J., McMahon, J. B., Boyd, M. R., Bader, J. P., Nickell, D. G., Barth, H., and Antonucci, T. K. (1994) Antiviral Res. 25, 43-56
16. Buckheit, R. W., Jr., Kinjerski, T. L., Fliakas Boltz, V., Russell, J. D., Stup, T. L., Pallansch, L. A., Brouwer, W. G., Dao, D. C., Harrison, W. A., Schultz, R. J., Bader, J. P., and Yang, S. S. (1995) Antimicrob. Agents Chemother. 39, 2718-2727
17. Balzarini, J., Perez-Perez, M. J., San-Felix, A., Camarasa, M. J., Bathurst, I. C., Barr, P. J., and De Clercq, E. (1992) J. Biol. Chem. 267, 11831-11838
18. Carroll, S. S., Stahlhut, M., Geib, J., and Olsen, D. B. (1994) J. Biol. Chem. 269, 32351-32357
19. Gu, Z., Quan, Y., Li, Z., Arts, E. J., and Wainberg, M. A. (1995) J. Biol. Chem. 270, 31046-31051
20. Villahermosa, M. L., Martinez-Irujo, J. J., Cabodevilla, F., and Santiago, E. (1997) Biochemistry 36, 13223-13231
21. Tramontano, E., and Cheng, Y. C. (1992) Biochem. Pharmacol. 43, 1371-1376
22. Chattopadhyay, D., Evans, D. B., Deibel, M. R., Jr., Vosters, A. F., Eckenrode, F. M., Einspahr, H. M., Hui, J. O., Tomasselli, A. G., Zurcher Neely, H. A., and Heinrikson, R. L. (1992) J. Biol. Chem. 267, 14227-14232
23. Cabodevilla, J. F., Odriozola, L., Santiago, E., and Martinez-Irujo, J. J. (2001) Eur. J. Biochem. 268, 1163-1172
24. Martinez-Irujo, J. J., Villahermosa, M. L., Mercapide, J., Cabodevilla, J. F., and Santiago, E. (1998) Biochem. J. 329, 689-698
25. Berenbaum, M. C. (1977) Clin. Exp. Immunol. 28, 1-18
26. Rigourd, M., Ehresmann, C., Parniak, M. A., Ehresmann, B., and Marquet, R. (2002) J. Biol. Chem. 277, 18611-18618
27. Ren, J., Esnouf, R. M., Hopkins, A. L., Jones, E. Y., Kirby, I., Keeling, J., Ross, C. K., Larder, B. A., Stuart, D. I., and Stammers, D. K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9518-9523
28. Boyer, P. L., Tantillo, C., Jacobo Molina, A., Nanni, R. G., Ding, J., Arnold, E., and Hughes, S. H. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 4882-4886
29. Chong, K. T., Pagano, P. J., and Hinshaw, R. R. (1994) Antimicrob. Agents Chemother. 38, 288-293
30. Goldman, M. E., Nunberg, J. H., O'Brien, J. A., Quintero, J. C., Schleif, W. A., Freund, K. F., Gaul, S. L., Saari, W. S., Wai, J. S., Hoffman, J. M., Anderson, P. S., Hupe, D. J., Emini, E. A., and Stern, A. M. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 6863-6867
31. Buckheit, R. W., Jr., Germany Decker, J., Hollingshead, M. G., Allen, L. B., Shannon, W. M., Janssen, P. A., and Chirigos, M. A. (1993) AIDS Res. Hum. Retroviruses. 9, 1097-1106