Kinetic mechanism of AKT/PKB enzyme family

Journal of Biological Chemistry

Volumn 281, Issue 20, 2006, Pages 13949-13956

  Zhang, Xiaoling ^a   Zhang, Shiwen ^a   Yamane, Harvey ^a   Wahl, Robert ^a   Ali, Arisha ^a   Lofgren, Julie A ^a   Kendall, Richard L ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CATALYSIS; ONCOLOGY; POLYPEPTIDES; SUBSTRATES; TUMORS;

ISOZYMES; KINETIC MECHANISMS; SIGNAL TRANSDUCTION; TUMORIGENESIS;

ENZYME KINETICS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ISOENZYME; PEPTIDE; PHOSPHOPEPTIDE; PHOSPHOTRANSFERASE; PROTEIN AKT1; PROTEIN AKT3; PROTEIN KINASE B; PROTEIN KINASE B BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; STEADY STATE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ANIMALS; CATALYSIS; HUMANS; KINETICS; PEPTIDES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; RATS;

EID: 33744931166     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601384200     Document Type: Article

References (55)

1. Staal, S. P., Hartley, J. W., and Rowe, W. P. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 3065-3067
2. Staal, S. P. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 5034-5037
3. Jones, P. F., Jakubowicz, T., Fernando, J. P., Maurer, F., and Hemmings, B. A. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 4171-4175
4. Bellacosa, A., Testa, J. R., Staal, S. P., and Tsichlis, P. N. (1991) Science 254, 274-277
5. Coffer, P. J., and Woodgett, J. R. (1991) Eur. J. Biochem. 201, 475-481
6. Jones, P. F., Jakubowicz, T., and Hemmings, B. A. (1991) Cell Regul. 2, 1001-1019
7. Cheng, J. Q., Godwin, A. K., Bellacosa, A., Taguchi, T., Franke, T. F., Hamilton, T. C., Tsichlis, P. N., and Testa, J. R. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 9267-9271
8. Konishi, H., Kuroda, S., Tanaka, M., Matsuzaki, H., Ono, Y., Kameyama, K., Haga, T., and Kikkawa, U. (1995) Biochem. Biophys. Res. Commun. 216, 526-534
9. Nakatani, K., Sakaue, H., Thompson, D. A., Weigel, R. J., and Roth, R. A. (1999) Biochem. Biophys. Res. Commun. 257, 906-910
10. Brodbeck, D., Cron, P., and Hemmings, B. A. (1999) J. Biol. Chem. 274, 9133-9136
11. Masure, S., Haefner, B., Wesselink, J. J., Hoefnagel, E., Mortier, E., Verhasselt, P., Tuytelaars, A., Gordon, R., and Richardson, A. (1999) Eur. J. Biochem. 265, 353-360
12. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N. (1995) Cell 81, 727-736
13. Burgering, B. M., and Coffer, P. J. (1995) Nature 376, 599-602
14. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
15. Franke, T. F., Kaplan, D. R., Cantley, L. C., and Toker, A. (1997) Science 275, 665-668
16. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
17. Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F., and Hawkins, P. T. (1997) Science 277, 567-570
18. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R., Reese, C. B., McCormick, F., Tempst, P., Coadwell, J., and Hawkins, P. T. (1998) Science 279, 710-714
19. Walker, K. S., Deak, M., Paterson, A., Hudson, K., Cohen, P., and Alessi, D. R. (1998) Biochem. J. 331, 299-308
20. Yang, J., Cron, P., Thompson, V., Good, V. M., Hess, D., Hemmings, B. A., and Barford, D. (2002) Mol. Cell 9, 1227-1240
21. Yang, J., Cron, P., Good, V. M., Thompson, V., Hemmings, B. A., and Barford, D. (2002) Nat. Struct. Biol. 9, 940-944
22. Feng, J. H., Park, J., Cron, P., Hess, D., and Hemmings, B. A. (2004) J. Biol. Chem. 279, 41189-41196
23. Dragoi, A. M., Fu, X. Y., Ivanov, S., Zhang, P., Sheng, L. B., Wu, D. Q., Li, G. C., and Chu, W. M. (2005) EMBO J. 24, 779-789
24. Viniegra, J. G., Martinez, N., Modirassari, P., Losa, J. H., Cobo, C. P., Lobo, V. J. S. A., Luquero, C. I. A., Alvarez-Vallina, L., Cajal, S. R. Y., Rojas, J. M., and Sanchez-Prieto, R. (2005) J. Biol. Chem. 280, 4029-4036
25. Sarbassov, D. D, Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
26. Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Genes Dev. 13, 2905-2927
27. Lawlor, M. A., and Alessi, D. R. (2001) J. Cell Sci. 114, 2903-2910
28. Manning, B. D., and Cantley, L. C. (2003) Biochem. Soc. Trans. 31, 573-578
29. Brazil, D. P., Yang, Z. Z., and Hemmings, B. A. (2004) Trends Biochem. Sci. 29, 233-242
30. Alessi, D. R., and Cohen, P. (1998) Curr. Opin. Genet. Dev. 8, 55-62
31. Obata, T., Yaffe, M. B., Leparc, G. G., Piro, E. T., Maegawa, H., Kashiwagi, A., Kikkawa, R., and Cantley, L. C. (2000) J. Biol. Chem. 275, 36108-36115
32. Meier, R., Alessi, D. R., Cron, P., Andjelkovic, M., and Hemmings, B. A. (1997) J. Biol. Chem. 272, 30491-30497
33. Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., III, Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., and Birnbaum, M. J. (2001) Science 292, 1728-1731
34. Chen, W. S., Xu, P. Z., Gottlob, K., Chen, M. L., Sokol, K., Shiyanova, T., Roninson, I., Weng, W., Suzuki, R., Tobe, K., Kadowaki, T., and Hay, N. (2001) Genes Dev. 15, 2203-2208
35. Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., and Birnbaum, M. J. (2001) J. Biol. Chem. 276, 38349-38352
36. Easton, R. M., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M. Y., Szabolcs, M., de Jong, R., Oltersdorf, T., Ludwig, T., Efstratiadis, A., and Birnbaum, M. J. (2005) Mol. Cell. Biol. 25, 1869-1878
37. Bae, S. S., Cho, H., Mu, J., and Birnbaum, M. J. (2003) J. Biol. Chem. 278, 49530-49536
38. Cook, P. F., Neville, M. E., Jr., Vrana, K. E., Hartl, F. T., and Roskoski, R., Jr. (1982) Biochemistry 21, 5794-5799
39. Whitehouse, S., Feramisco, J. R., Casnellie, J. E., Krebs, E. G., and Walsh, D. A. (1983) J. Biol. Chem. 258, 3693-3701
40. Qamar, R., Yoon, M. Y., and Cook, P. F. (1992) Biochemistry 31, 9986-9992
41. Qamar, R., and Cook, P. F. (1993) Biochemistry 32, 6802-6806
42. Ramaswamy, S., Nakamura, N., Vazquez, F., Batt, D. B., Perera, S., Roberts, T. M., and Sellers, W. R. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 2110-2115
43. Nakamura, N., Ramaswamy, S., Vazquez, F., Signoretti, S., Loda, M., and Sellers, W. R. (2000) Mol. Cell. Biol. 20, 8969-8982
44. Leatherbarrow, R. J. (2001) GraFit, Version 5, Erithacus Software Ltd., Horley, UK
45. Cleland, W. W. (1963) Biochim. Biophys. Acta 8, 104-137
46. Cleland, W. W. (1963) Biochim. Biophys. Acta 12, 173-187
47. Cleland, W. W. (1963) Biochim. Biophys. Acta 12, 188-196
48. Segel, I. H. (1993) Enzyme Kinetics, John Wiley & Sons, Inc., New York
49. Zheng, J., Knighton, D. R., ten Eyck, L. F., Karlsson, R., Xuong, N., Taylor, S. S., and Sowadski, J. M. (1993) Biochemistry 32, 2154-2161
50. Hresko, R. C., Heimberg, H., Chi, M. M. Y., and Mueckler, M. (1998) J. Biol. Chem. 273, 20658-20668
51. Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., and Thomas, G. (2001) Science 294, 1102-1105
52. Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R. B., and Hay, N. (2001) Genes Dev. 15, 1406-1418
53. Majewski, N., Nogueira, V., Bhaskar, P., Coy, P. E., Skeen, J. E., Gottlob, K., Chandel, N. S., Thompson, C. B., Robey, R. B., and Hay, N. (2004) Mol. Cell 16, 819-830
54. Nagata, D., Mogi, M., and Walsh, K. (2003) J. Biol. Chem. 278, 31000-31006
55. Hahn-Windgassen, A., Nogueira, V., Chen, C. C., Skeen, J. E., Sonenberg, N., and Hay, N. (2005) J. Biol. Chem. 280, 32081-32089