Synthesis of four chiral isomers of β-lactone DU-6622 and inhibition of HMG-CoA synthase by the specific (2R,3R)-isomer

Journal of Organic Chemistry

Volumn 62, Issue 7, 1997, Pages 2161-2165

  Tomoda, Hiroshi ^a   Kumagai, Hidetoshi ^a   Ogawa, Yuji ^d   Sunazuka, Toshiaki ^a   Hashizume, Hirokazu ^b   Nagashima, Hajime ^c   Omura, Satoshi ^a  

^a KITASATO UNIVERSITY   (Japan)

^b FUJI CHEMICAL INDUSTRIES LTD   (Japan)

^c DAIICHI SANKYO CO   (Japan)

^d Sendagaya   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DU 6622; HMG COA SYNTHASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; IN VITRO STUDY; LIVER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 0030921945     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9621433     Document Type: Article

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