Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (β-Lactones)

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 8, 1998, Pages 1255-1272

  Romo, Daniel ^a   Harrison, Paul H M ^b   Jenkins, Stephen I ^b   Riddoch, R William ^b   Park, Kaapjoo ^a   Yang, Hong Woon ^a   Zhao, Cunxiang ^a   Wright, Gerard D ^c  

^a TEXAS A AND M UNIVERSITY   (United States)

^b MCMASTER UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Lactones; Asymmetric synthesis; Chiral Lewis acid; HMG CoA synthase; Inhibition

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; LACTONE DERIVATIVE; PROPIOLACTONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; REACTION ANALYSIS; SACCHAROMYCES CEREVISIAE; STEREOCHEMISTRY;

ENZYME INHIBITORS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; LACTONES; SACCHAROMYCES CEREVISIAE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

SACCHAROMYCES CEREVISIAE;

EID: 0031679829     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00114-X     Document Type: Article

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