CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely

Transplant Immunology

Volumn 10, Issue 1, 2002, Pages 55-61

  Corbascio, Matthias ^a   Ekstrand, Helene ^a   Österholm, Cecilia ^a   Qi, Zhongquan ^a   Simanaitis, Mecislovas ^a   Larsen, Christian P ^b   Pearson, Thomas C ^b   Riesbeck, Kristian ^a   Ekberg, Henrik ^a  

^a LUND UNIVERSITY   (Sweden)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allograft; Anti LFA 1; CTLA4Ig; Heart transplant; Skin grafts

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOMODULATING AGENT; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1 MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; ABATACEPT; ANTIBODY CONJUGATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; DRUG TARGETING; GRAFT REJECTION; GRAFT SURVIVAL; GROWTH INHIBITION; HEART TRANSPLANTATION; HISTOLOGY; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MIXED LYMPHOCYTE REACTION; MONOTHERAPY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; SIGNAL TRANSDUCTION; SKIN GRAFT; SKIN TRANSPLANTATION; T LYMPHOCYTE ACTIVATION; VASCULARIZATION; ALLOTRANSPLANTATION; ANIMAL; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MIXED LYMPHOCYTE CULTURE; PHYSIOLOGY;

ANIMAL; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOCONJUGATES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; MICE; MICE, INBRED STRAINS; SKIN TRANSPLANTATION; TRANSPLANTATION, HOMOLOGOUS; ANIMALS;

EID: 0036023131     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(02)00014-X     Document Type: Article

References (23)

1. A cell culture model for T lymphocyte clonal anergy
2. Differential regulatory effects of intercellular adhesion molecule-1 on costimulation by the CD28 counter-receptor B7
3. Regulation of T cell subsets from naive to memory
4. Regulation of CD40 ligand expression on naive CD4 T cells: A role for TCR but not co-stimulatory signals
5. Adhesion receptors of the immune system
6. Between B cells and T cells
7. How B and T cells talk to each other
8. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1
9. CTLA-4 is a second receptor for the B cell activation antigen B7
10. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
11. Local CTLA4Ig synergizes with one-dose anti-LFA-1 to achieve long-term acceptance of pancreatic islet allografts
12. Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts
13. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H2 antigens in rejection
14. Simplified mouse cervical heart transplantation using a cuff technique
15. Pathogenesis and prevention of graft arteriosclerosis in an experimental heart transplant model
16. Actively acquired tolerance of foreign cells
17. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
18. Distinct roles for LFA-1 and CD28 during activation of naive T cells: Adhesion versus costimulation
19. Transplantation tolerance induced by CTLA4-Ig
20. ICAM-1 and B7-1 provide similar but distinct costimulation for CD8+ T cells, while CD4+ T cells are poorly costimulated by ICAM-1
21. Functional significance of adhesion molecules in Fas-dependent apoptotic cell death induced by interleukin-2-activated T cells
22. Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice
23. Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1