Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5)

Journal of Biological Chemistry

Volumn 273, Issue 11, 1998, Pages 6460-6466

  Turko, Illarion V ^a   Francis, Sharron H ^a   Corbin, Jackie D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTIC ACID; CYCLIC GMP; GLUTAMIC ACID; HISTIDINE; PHOSPHODIESTERASE; ZAPRINAST;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CONSERVED SEQUENCE; CYCLIC GMP; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHODIESTERASE INHIBITORS; PURINONES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

FELIS CATUS; MAMMALIA;

EID: 0032513145     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.11.6460     Document Type: Article

References (35)

1. Beavo, J. A., Conti, M., and Heaslip, R. J. (1994) Mol. Pharmacol. 46, 399-405
2. Charbonneau, H., Beier, N., Walsh, K. A., and Beavo, J. A. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 9308-9312
3. Tucker, M. M., Robinson, J. B., Jr., and Stellwagen, E. (1981) J. Biol. Chem., 256, 9051-9058
4. Kincaid, R. L., Stith-Coleman, I. E., and Vaughan, M. (1985) J. Biol. Chem. 260, 9009-9015
5. Stroop, S. D., Charbonneau, H., and Beavo, J. A. (1989) J. Biol. Chem. 264, 13718-13725
6. Thomas, M. K., Francis, S. H., and Corbin, J. D. (1990) J. Biol. Chem. 265, 14964-14970
7. Jin, S.-L. C., Swinnen, J. V., and Conti, M. (1992) J. Biol. Chem. 267, 18929-18939
8. Cheung, P. P., Xu, H., McLaughlin, M. M., Ghazaleh, F. A., Livi, G. P., and Colman, R. W. (1996) Blood 88, 1321-1329
9. Jacobitz, S., McLaughlin, M. M., Livi, G. P., Burman, M., and Torphy, T. J. (1996) Mol. Pharmacol. 50, 891-899
10. McAllister-Lucas, L. M., Sonnenburg, W. K., Kadlecek, A., Seger, D., Le Trong, H., Colbran, J. L., Thomas, M. K., Walsh, K. A., Francis, S. H., Corbin, J. D., and Beavo, J. A. (1993) J. Biol. Chem. 268, 22863-22873
11. Turko, I. V., Haik, T. L., McAllister-Lucas, L. M., Burns, F., Francis, S. H., and Corbin, J. D. (1996) J. Biol. Chem. 271, 22240-22244
12. McAllister-Lucas, L. M., Haik, T. L., Colbran, J. L., Sonnenburg, W. K., Seger, D., Turko, I. V., Beavo, J. A., Francis, S. H., and Corbin, J. D. (1995) J. Biol. Chem. 270, 30671-30679
13. Francis, S. H., Colbran, J. L., McAllister-Lucas, L. M., and Corbin, J. D. (1994) J. Biol. Chem. 269, 22477-22480
14. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
15. Swinnen, J. V., Joseph, D. R., and Conti, M. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 5325-5329
16. Meacci, E., Taira, M., Moos, M., Jr., Smith, C. J., Movsesian, M. A., Degerman, E., Belfrage, P., and Manganiello, V. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3721-3725
17. Wilkinson, A. J., Fersht, A. R., Blow, D. M., and Winter, G. (1983) Biochemistry 22, 3581-3586
18. Wells, J. A., Powers, D. B., Bott, R. R., Graycar, T. P., and Estell, D. A. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 1219-1223
19. Fersht, A. R., Shi, J.-P., Knill-Jones, J., Lowe, D. M., Wilkinson, A. J., Blow, D. M., Brick, P., Carter, P., Waye, M. M. Y., and Winter, G. (1985) Nature 314, 235-238
20. Gillespie, P. G., and Beavo, J. A. (1989) Mol. Pharmacol. 36, 773-781
21. Omburo, G. A., Brickus, T., Ghazaleh, F. A., and Colman, R. W. (1995) Arch. Biochem. Biophys. 323, 1-5
22. Srivastava, D., Fox, D. A., and Hurwitz, R. L. (1995) Biochem. J. 308, 653-688
23. Jacobitz, S., Ryan, M. D., McLaughlin, M. M., Livi, G. P., DeWolf, W. E., and Torphy, T. J. (1997) Mol. Pharmacol. 51, 999-1006
24. Vazeux, G., Wang, J., Corvol, P., and Llorens-Cortes, C. (1996) J. Biol. Chem. 271, 9069-9074
25. Boldt, Y. R., Whiting, A. K., Wagner, M. L., Sadowsky, M. J., Que, L., Jr., and Wackett, L. P. (1997) Biochemistry 36, 2147-2153
26. Ishikawa, K., Suzuki, E.-i., Tanokura, M., and Takahashi, K. (1996) Biochemistry 35, 8329-8334
27. Strelkov, S. V., Perisic, O., Webb, P. A., and Williams, R. L. (1995) J. Mol. Biol. 249, 665-674
28. Gidh-Jain, M., Zhang, Y., van Poelje, P. D., Liang, J.-Y., Huang, S., Kim, J., Elliott, J. T., Erion, M. D., Pilkis, S. J., El-Maghrabi, M. R., and Lipscomb, W. N. (1994) J. Biol. Chem. 269, 27732-27738
29. Su, Y., Dostmann, W. R. G., Herberg, F. W., Durick, K., Xuong, N-h., Ten Eyck, L., Taylor, S. S., and Varughese, K. I. (1995) Science 269, 807-813
30. Francis, S. H., Thomas, M. K., and Corbin, J. D. (1990) Cyclic Nucleotide Phosphodiesterases (Beavo, J., and Houslay, M., eds) pp. 117-135, John Wiley & Sons, Ltd., Chichester, England
31. Beltman, J., Becker, D. E., Butt, E., Jensen, G. S., Rybalkin, S. D., Jastorff, B., and Beavo, J. A. (1995) Mol. Pharmacol. 47, 330-339
32. Chen, C.-N., Denome, S., and Davis, R. L. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 9313-9317
33. Sass, P., Field, J., Nikawa, J., Toda, T., and Wigler, M. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 9303-9307
34. Weber, I. T., and Steitz, T. A. (1987) J. Mol. Biol. 198, 311-326
35. Shabb, J. B., and Corbin, J. D. (1992) J. Biol. Chem. 267, 5723-5726