Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities

European Journal of Biochemistry

Volumn 267, Issue 9, 2000, Pages 2760-2767

  Corbin, Jackie D ^a   Turko, Illarion V ^a   Beasley, Alfreda ^a   Francis, Sharron H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CGMP; Cyclic nucleotide; Feedback regulation; Phosphodiesterase; Protein phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE MAGNESIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC NUCLEOTIDE DEPENDENT PROTEIN KINASE; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; RECOMBINANT ENZYME; SILDENAFIL; ZAPRINAST;

ALLOSTERISM; ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; FEEDBACK SYSTEM; MICHAELIS CONSTANT; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ALLOSTERIC REGULATION; ANIMALS; CATALYSIS; CATTLE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; PHOSPHORIC DIESTER HYDROLASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

BOVINAE;

EID: 0034108626     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01297.x     Document Type: Article

References (40)

1. 1. Corbin, J.D. & Francis, S.H. (1999) Cyclic GMP phosphodiesterase-5: target of sildenafil. J. Biol. Chem. 274, 13729-13732.
2. 2. Beavo, J.A., Conti, M. & Heaslip, R.J. (1994) Multiple cyclic nucleotide phosphodiesterascs. Mol. Pharmacol 46, 399-405.
3. 3. Conti, M., Nemoz, G., Sette, C. & Vicini, E. (1995) Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocr. Rev. 16, 370-389.
4. 4. Degerman, E., Belfrage, P. & Manganiello, V.C. (1997) Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3). J. Biol Chem. 272, 6823-6826.
5. 5. Houslay, M.D. (1995) Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk, desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP. Adv. Enzyme Regul. 35, 303-338.
6. 6. Bolger, G.B. (1994) Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes. Cell. Signal. 6, 851-859.
7. 7. Thompson, W.J., Lavis, V.R., Whalin, M.E. & Strada, S.J. (1992) Regulatory mechanisms of particulate cyclic nucleotide phosphodiesterases. Adv. Second Messenger Phosphoprotein Res. 25, 165-184.
8. 8. Underwood, D.C., Kotzer, C.J., Bochnowicz, S., Osborn, R.R., Luttmann, M.A., Hay, D.W.P. & Torphy, T.J. (1994) Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. J. Pharmacol. Exp. Ther. 270, 250-259.
9. 9. Ballard, S.A., Gingell, C.J., Tang, K., Turner, L.A., Price, M.E. & Naylor, A.M. (1998) Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J. Urol. 159, 2164-2171.
10. 10. Thomas, M.K., Francis, S.H. & Corbin, J.D. (1990) Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase. J. Biol. Chem. 265, 14964-14970.
11. 11. Thomas, M.K., Francis, S.H. & Corbin, J.D. (1990) Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP. J. Biol. Chem. 265, 14971-14978.
12. 12. McAllister-Lucas, L.M., Sonnenburg, W.K., Kadlecek, A., Seger, D., LeTrong, H., Colbran, J.L., Thomas, M.K., Walsh, K.A., Francis, S.H., Corbin, J.D. & Beavo, J.A. (1993) The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone. J. Biol. Chem. 268, 22863-22873.
13. 13. Francis, S.H., Thomas, M.K. & Corbin, J.D. (1990) Cyclic GMP-binding cyclic GMP-specific phosphodiesterase from lung. In Cyclic Nucleotide Phosphodiesterases: Structure, Regulation, and Drug Action (Beavo, J. & Houslay, M.D., eds), pp. 117-140. John Wiley & Sons, New York.
14. 14. Wyatt, T.A., Naftilan, A.J., Francis, S.H. & Corbin, J.D. (1998) ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells. Am. J. Physiol. 274, H448-H455.
15. 15. Wolfe, L., Corbin, J.D. & Francis, S.H. (1989) Characterization of a novel isozyme of cGMP-dependent protein kinase from bovine aorta. J. Biol. Chem. 264, 7734-7741.
16. 16. McAllister-Lucas, L.M., Haik, T.L., Colbran, J.L., Sonnenburg, W.K., Seger, D., Turko, I.V., Beavo, J.A., Francis, S.H. & Corbin, J.D. (1994) An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase. J. Biol. Chem. 270, 30671-30679.
17. 17. Francis, S.H., Wolfe, L. & Corbin, J.D. (1991) Purification of type I alpha and type I beta isozymes and proteolyzed type I beta monomeric enzyme of cGMP-dependent protein kinase from bovine aorta. Methods Enzymol. 200, 332-341.
18. 18. Flockhart, D.A. & Corbin, J.D. (1984) Preparation of the catalytic subunit of cAMP-dependent protein kinase. In Brain Receptor Methodologies (Marangos, P.J., Campbell, I.C. & Cohen, R.M., eds). pp. 209-215. Academic Press, Orlando.
19. 19. Turko, I.V., Francis, S.H. & Corbin, J.D. (1998) Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase. J. Biol. Chem. 273, 6460-6466.
20. 20. Smith, J.A., Francis, S.H., Walsh, K.A., Kumar, S. & Corbin, J.D. (1996) Autophosphorylation of type Ibeta cGMP-dependent protein kinase increases basal catalytic activity and enhances allosteric activation by cGMP or cAMP. J. Biol. Chem 271, 20756-20762.
21. 21. Francis, S.H., Noblett, B.D., Todd, B.W., Wells, J.N. & Corbin, J.D. (1988) Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Mol. Pharmacol. 34, 506-517.
22. 22. Sette, C. & Conti, M. (1996) Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation. J. Biol. Chem. 271, 16526-16534.
23. 23. Francis, S.H. & Kono, T. (1982) Hormone-sensitive cAMP phosphodiesterase in liver and fat cells. Mol. Cell. Biochem. 42, 109-116.
24. 24. Manganiello, V.C., Tanaka, T. & Murashima, S. (1990) Cyclic GMP-stimulated cyclic nucleotide phosphodiesterases. In Cyclic Nucleotide Phosphodiesterases: Stucture, Regulation and Drug Action (Beavo, J. & Houslay, M.D., eds), pp. 61-85. John Wiley & Sons, Chichester.
25. 25. Turko, I.V., Ballard, S.A., Francis, S.H. & Corbin, J.D. (1999) Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. Mol. Pharmacol. 56, 124-130.
26. 26. Burns, F. & Pyne, N.J. (1992) Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites. Biochem. Biophys. Res. Commun. 189, 1389-1396.
27. 27. Corbin, J.D., Sugden, PH., Lincoln, T.M. & Keely, S.L. (1977) Compartmentalization of adenosine 3′: 5′-monophosphate and adenosine 3′:5′-monophosphate-dependent protein kinase in heart tissue. J. Biol. Chem. 252, 3854-3861.
28. 28. Corbin, J.D., Beebe, S.J. & Blackmore, P.F. (1985) cAMP-dependent protein kinase activation lowers hepatocyte cAMP. J. Biol. Chem. 260, 8731-8735.
29. 29. Sette, C, Iona, S. & Conti, M. (1994) The short-term activation of a Rolipram-sensitive, cAMP-specific phosphodiesterase by thyroidstimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation. J. Biol. Chem. 269, 9245-9252.
30. 30. Loten, E.G. & Sneyd, J.G. (1970) An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase. Biochem. J. 120, 187-193.
31. 31. Gettys, T.W., Blackmore, P.F., Redmon, J.B., Beebe, S.J. & Corbin, J.D. (1987) Short-term feedback regulation of cAMP by accelerated degradation in rat tissues. J. Biol. Chem. 262, 333-339.
32. 32. Conti, M., Iona, S., Cuomo, M., Swinnen, J.V., Odeh, J. & Svoboda, M.E. (1995) Characterization of a hormone-inducible, high affinity adenosine 3′-5′-cyclic monophosphate phosphodiesterase from the rat Sertoli cell. Biochemislry 34, 7979-7987.
33. 33. Swinnen, J.V., Joseph, D.R. & Conti, M. (1989) The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP. Proc. Natl Acad. Sci. USA 86, 8197-8201.
34. 34. Smith, C.J., Vasta, V., Degerman, E., Belfrage, P. & Manganiello, V.C. (1991) Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation. J. Biol. Chem. 266, 13385-13390.
35. 35. Francis, S.H., Lincoln, T.M. & Corbin, J.D. (1980) Characterization of a novel cGMP binding protein from rat lung. J. Biol. Chem. 255, 620-626.
36. 36. Turko, I.V., Francis, S.H. & Corbin, J.D. (1998) Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation. Biochem. J. 329, 505-510.
37. 37. Weber, G. (1975) Energetics of ligand binding to protein. Adv. Protein Chem. 29, 1-83.
38. 38. Martins, T.J., Mumby, M.C. & Beavo, J.A. (1982) Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues. J. Biol. Chem. 257, 1973-1979.
39. 39. Smolenski, A., Burkhardt, A.M., Eigenthaler, M., Butt, E., Gambaryan, S., Lohmann, S.M. & Walter, U. (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch. Pharmacol. 358, 134-139.
40. 40. Bakre, M.M. & Visweswariah, S.S. (1997) Dual regulation of heatstable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity. FEBS Lett. 408, 345-349.