Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: Microarray analysis of dose- and time-dependent effects

Cancer Research

Volumn 62, Issue 6, 2002, Pages 1688-1695

  Zhou, Yi ^a,b   Gwadry, Fuad G ^a   Reinhold, William C ^a   Miller, Lance D ^c   Smith, Lawrence H ^a   Scherf, Uwe ^a   Liu, Edison T ^a   Kohn, Kurt W ^a   Pommier, Yves ^a   Weinstein, John N ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Cellular Genomics Inc   (United States)

^c Advanced Technology Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; CAMPTOTHECIN; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL SYNCHRONIZATION; COLON CANCER; CONTROLLED STUDY; CORRELATION COEFFICIENT; CYTOTOXICITY; DNA DAMAGE; DNA MICROARRAY; DOSE TIME EFFECT RELATION; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MITOSIS; NORTHERN BLOTTING; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

APHIDICOLIN; CAMPTOTHECIN; CELL CYCLE; COLONIC NEOPLASMS; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; G2 PHASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, CDC; HUMANS; MITOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 0037086088     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5’-phosphorylated DNA double-strand breaks by replication runoff
2. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme
3. The cell cycle effects of camptothecin
4. Camptothecin resistance related to drug-induced down-regulation of topoisomerase I and to steps occurring after the formation of protein-linked DNA breaks
5. Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen
6. Induction of apoptosis in MCF-7:WS8 breast cancer cells by β-lapachone
7. Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways
8. Systematic variation in gene expression patterns in human cancer cell lines
9. A gene expression database for the molecular pharmacology of cancer
10. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
11. Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes
12. Use of a cDNA microarray to analyse gene expression patterns in human cancer
13. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
14. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage
15. Ratio-based decisions and quantitative analysis of cDNA microarray images
16. Predictive statistics and artificial intelligence in the U.S. National Cancer Institute’s Drug Discovery Program for Cancer and AIDS
17. An information-intensive approach to the molecular pharmacology of cancer
18. A protein expression database for the molecular pharmacology of cancer
19. Cluster analysis and display of genome-wide expression patterns
20. Cell cycle re-entry following chemically-induced cell cycle synchronization leads to elevated p53 and p21 protein levels
21. Cytotoxic effects of cell cycle phase specific agents: Result of cell cycle perturbation
22. Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2
23. Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events
24. Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway
25. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
26. Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif
27. The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in xenopus laevis
28. Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos
29. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
30. The transcriptional program in the response of human fibroblasts to serum
31. 2arrest: Altered regulation of p34cdc2/cyclin B
32. 2checkpoint
33. p53 regulates a G2 checkpoint through cyclin B1
34. Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells
35. 2arrest after DNA damage
36. Cell cycle. Checkpoint on the nuclear frontier
37. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
38. Tumor necrosis factor receptor-associated factor (TRAF) family: Adapter proteins that mediate cytokine signaling
39. Accumulation of p16CDKN2A in response to ultraviolet irradiation correlates with late S-G(2)-phase cell cycle delay
40. WAF1, a potential mediator of p53 tumor suppression
41. 14-3-3σ is a p53-regulated inhibitor of G2/M progression
42. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
43. The structure and expression of the murine wildtype p53-induced phosphatase I (Wip1) gene
44. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
45. Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation
46. Intracellular signaling of the TGF-β superfamily by Smad proteins
47. Identification of the genes responsive to etoposide-induced apoptosis: Application of DNA chip technology