2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: Functionally selective GABAA α3-subtype agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3550-3554

  Carling, Robert W ^a   Russell, Michael G N ^a   Moore, Kevin W ^a   Mitchinson, Andrew ^a   Guiblin, Alexander ^a   Smith, Alison ^a   Wafford, Keith A ^a   Marshall, George ^a   Atack, John R ^a   Street, Leslie J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

GABAA Benzodiazepine modulatory site; Pyrazolo 1,5 d 1,2,4 triazines; Subtype selective agonists

Indexed keywords

1,2,4 TRIAZINE DERIVATIVE; 3 THIOPHENE; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BENZODIAZEPINE; PYRAZOLO[1,5 D][1,2,4]TRIAZINE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG STRUCTURE; IN VITRO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT;

BINDING SITES; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PYRAZOLES; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 33646843565     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.081     Document Type: Article

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