Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit

Journal of Medicinal Chemistry

Volumn 48, Issue 5, 2005, Pages 1367-1383

  Russell, Michael G N ^a   Carling, Robert W ^a   Atack, John R ^a   Bromidge, Frances A ^a   Cook, Susan M ^a   Hunt, Peter ^a   Isted, Catherine ^a   Lucas, Matt ^a   McKernan, Ruth M ^a   Mitchinson, Andrew ^a   Moore, Kevin W ^a   Narquizian, Robert ^a   Macaulay, Alison J ^a   Thomas, David ^a   Thompson, Sally Anne ^a   Wafford, Keith A ^a   Castro, José L ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 6 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; 3 PHENYL 6 [(1 PROPYL 1H 1,2,4 TRIAZOL 3 YL)METHOXY]7,8,9,10 TETRAHYDRO 7,10 ETHANO 1,2,4 TRIAZOLO[3,4 A]PHTHALAZINE; 3 PHENYL 6 [(1 PROPYL 1H 1,2,4 TRIAZOL 5 YL)METHOXY]7,8,9,10 TETRAHYDRO 7,10 ETHANO 1,2,4 TRIAZOLO[3,4 A]PHTHALAZINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 7,8,9,10 TETRAHYDRO 7,10 ETHANO 1,2,4 TRIAZOLO[3,4 A]PHTHALAZINE; DIAZEPAM; FLUMAZENIL; RECEPTOR SUBTYPE; TRIAZOLO[3,4 A]PHTHALAZINE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CHEMICAL STRUCTURE; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NEUROTRANSMISSION; NONHUMAN; OOCYTE; PROTON NUCLEAR MAGNETIC RESONANCE; VOLTAGE CLAMP; XENOPUS;

ANIMALS; BINDING SITES; CELL LINE; FEMALE; HUMANS; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; PHTHALAZINES; PROTEIN SUBUNITS; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; XENOPUS LAEVIS;

EID: 20144379294     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040883v     Document Type: Article

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