Discovery of imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 subtype selective agonists for the treatment of anxiety

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1235-1238

  Russell, Michael G N ^a   Carling, Robert W ^a   Street, Leslie J ^a   Hallett, David J ^a   Goodacre, Simon ^a   Mezzogori, Elena ^a   Reader, Michael ^a   Cook, Susan M ^a   Bromidge, Frances A ^a   Newman, Robert ^a   Smith, Alison J ^a   Wafford, Keith A ^a   Marshall, George R ^a   Reynolds, David S ^a   Dias, Rebecca ^a   Ferris, Pushpindar ^a   Stanley, Jo ^a   Lincoln, Rachael ^a   Tye, Spencer J ^a   Sheppard, Wayne F A ^a   Sohal, Bindi ^a   Pike, Andrew ^a   Dominguez, Maria ^a   Atack, John R ^a   Castro, José L ^a   more..

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A ALPHA 2 RECEPTOR; 4 AMINOBUTYRIC ACID A ALPHA 3 RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; IMIDAZO[1,2 B] 1,2,4 TRIAZINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; SEDATION; SQUIRREL MONKEY; STRUCTURE ANALYSIS; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; BIOLOGICAL AVAILABILITY; HALF-LIFE; HUMANS; IMIDAZOLES; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; SAIMIRI; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 33144489883     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051200u     Document Type: Article

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