Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 35-38

  Goodacre, Simon C ^a   Street, Leslie J ^a   Hallett, David J ^a   Crawforth, James M ^a   Kelly, Sarah ^a   Owens, Andrew P ^a   Blackaby, Wesley P ^a   Lewis, Richard T ^a   Stanley, Joanna ^a   Smith, Alison J ^a   Ferris, Pushpinder ^a   Sohal, Bindi ^a   Cook, Susan M ^a   Pike, Andrew ^a   Brown, Nicola ^a   Wafford, Keith A ^a   Marshall, George ^a   Castro, José L ^a   Atack, John R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A ALPHA2 RECEPTOR; 4 AMINOBUTYRIC ACID A ALPHA3 RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 7 METHYLIMIDAZOPYRIDINE; 7 PROPAN 2 OL IMIDAZOPYRIMIDINE; 7 TRIFLUOROMETHYLIMIDAZOPYRIMIDINE; DIAZEPAM; IMIDAZO[1,2 A]PYRIMIDINE DERIVATIVE; NS 2710; UNCLASSIFIED DRUG;

ANXIETY DISORDER; ARTICLE; DRUG BIOAVAILABILITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; NEUROTRANSMISSION; NONHUMAN; SEDATION; TRANQUILIZING ACTIVITY;

ADMINISTRATION, ORAL; ANIMALS; ANXIETY DISORDERS; BINDING SITES; BIOLOGICAL AVAILABILITY; CELL LINE; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; MOLECULAR STRUCTURE; PATCH-CLAMP TECHNIQUES; PYRIMIDINES; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 30444455608     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051065l     Document Type: Article

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37. th Meeting of the American Chemical Society, San Diego, March 2005: American Chemical Society: Washington, DC, 2005; MEDI 022.