Tricyclic pyridones as functionally selective human GABA Aα2/3 receptor-ion channel ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 7, 2004, Pages 1679-1682

  Crawforth, James ^a   Atack, John R ^a   Cook, Susan M ^a   Gibson, Karl R ^a   Nadin, Alan ^a   Owens, Andrew P ^a   Pike, Andrew ^a   Rowley, Michael ^a   Smith, Alison J ^a   Sohal, Bindi ^a   Sternfeld, Francine ^a   Wafford, Keith ^a   Street, Leslie J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

GABAA; Tricyclic pyridones

Indexed keywords

1 METHYLPYRROLE; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZENE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; ION CHANNEL; ISOXAZOLE DERIVATIVE; LIGAND; PYRIDINE DERIVATIVE; PYRIDONE DERIVATIVE; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOG; EVALUATION; LIVER MICROSOME; NONHUMAN; RAT; RODENT; SEDATION; TRANQUILIZING ACTIVITY;

HUMANS; ION CHANNEL GATING; LIGANDS; PROTEIN BINDING; PROTEIN SUBUNITS; PYRIDONES; RECEPTORS, GABA-A;

RODENTIA;

EID: 12144289942     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.057     Document Type: Article

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