A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 283, Issue 4 27-4, 2002, Pages

  Watanabe, Nobuo ^a   Dickinson, Dale A ^a   Krzywanski, David M ^a   Iles, Karen E ^a   Zhang, Hongqiao ^a   Venglarik, Charles J ^a   Forman, Henry Jay ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Apoptosis; Caspase; Enzyme; Genetic instability; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; ALDEHYDE REDUCTASE; ANISOMYCIN; CASPASE 3; CASPASE 9; CATALASE; DACTINOMYCIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CELL DEATH; CELL ISOLATION; CELL LINE; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC STABILITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR CLONING; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEADY STATE;

EID: 0036784105     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00025.2002     Document Type: Article

References (44)

1. Catalase in vitro
2. 4-Hydroxyalk-2-enals are substrates for glutathione transferase
3. Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells
4. Preparation and assay of mammalian thioredoxin and thioredoxin reductase
5. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
6. Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury
7. Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels
8. Expression of NAD(P)H:Quinone oxidoreductase 1 in HeLa cells: Role of hydrogen peroxide and growth phase
9. Free radical damage to cultured porcine aortic endothelial cells and lung fibroblasts: Modulation by culture conditions
10. Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism
11. Glutathione reductase
12. Triggering and modulation of apoptosis by oxidative stress
13. Recent trends in glutathione biochemistry-glutathione-protein interactions: A molecular link between oxidative stress and cell proliferation?
14. Identification and characterization of different subpopulations in a human lung adenocarcinoma cell line (A549)
15. Cellular thiols and reactive oxygen species in drug-induced apoptosis
16. Clonal variation of cadmium response in human tumor cell lines
17. High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives
18. The enzymatic reduction of actinomycin D to a free radical species
19. Assays of glutathione peroxidase
20. Measurement of γ-glutamyl transpeptidase and γ-glutamyl-cysteine synthetase activities in cells
21. Transformation in culture of animal cells
22. In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors
23. Mitochondria and apoptosis
24. Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells
25. Expression of γ-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell death
26. Suppression of manganese superoxide dismutase augments sensitivity to radiation, hyperthermia and doxorubicin in colon cancer cell lines by inducing apoptosis
27. Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: Mechanistic studies
28. DT-diaphorase: Purification, properties, and function
29. γ-glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal
30. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1
31. Glutathione transferase (human placenta)
32. Superoxide dismutase: An enzymic function for erythrocuprein (hemocuprein)
33. Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway
34. Gene transfer of mitochondrially targeted glutathione reductase protects H441 cells from t-butyl hydroperoxide-induced oxidant stresses
35. Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells
36. 4-Hydroxynonenal in the pathomechanisms of oxidative stress
37. Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-α
38. 2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone
39. Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase
40. Requirement for coenzyme Q in plasma membrane electron transport
41. Importance of glucose-6-phosphate dehydrogenase activity for cell growth
42. Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line
43. A role for mitochondrial Bak in apoptotic response to anticancer drugs
44. Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2