Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine

Experimental Gerontology

Volumn 35, Issue 6-7, 2000, Pages 757-766

  Paul, C ^a   Arrigo, A P ^a  

^a CENTRE DE GÉNÉTIQUE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Apoptosis; Bcl 2; Heat shock proteins; Menadione; Reactive oxygen species; Staurosporine

Indexed keywords

GLUTATHIONE; HEAT SHOCK PROTEIN 27; MENADIONE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; CELL PROTECTION; CELL STRAIN L 929; CELL SURVIVAL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; HUMAN; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA; MURINAE;

EID: 0033784408     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00150-9     Document Type: Conference Paper

References (21)

1. Small stress proteins: Chaperones that act as regulators of intracellular redox state and programmed cell death
2. Diminished cell proliferation associated with the death-protective activity of Bcl-2
3. The protein Bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis
4. HSP27 inhibits cytochrome c-dependent activation of procaspase-9
5. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
6. Reactive oxygen species and programmed cell death
7. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species
8. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
9. Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis
10. Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts
11. Human hsp27, Drosophila hsp27 and human αB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these protein against TNFα-induced cell death
12. Small stress proteins as novel regulators of apoptosis, heat shock protein 27 blocks Fas/APO-1 and staurosporine-induced cell death
13. Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis
14. Accelerated growth and senescence of arterial endothelial cells expressing the small molecular weight heat-shock protein HSP27
15. Oxidants and antioxidants in proliferative senescence
16. Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery
17. Double identity for proteins of the Bcl-2 family
18. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines
19. Bcl-2 expression causes redistribution of glutathione to the nucleus
20. Senescent human fibroblasts resist programmed cell death, and failure to suppress Bcl2 is involved
21. Regulation of apoptosis resistance and ontogeny of age-dependent diseases