Tackling the insulin-signalling cascade

Canadian Journal of Diabetes

Volumn 29, Issue 3, 2005, Pages 239-245

  Glund, Stephan ^a   Zierath, Juleen R ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Glucose uptake; Insulin signalling; Pharmacologic intervention; Skeletal muscle

Indexed keywords

INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ENZYME ACTIVITY; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; INSULIN TREATMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 33646707285     PISSN: 14992671     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Kahn CR. Banting lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes. 1994;43:1066-1084.
2. DeFronzo RA, Gunnarsson R, Björkman O, et al. Effects of insulin on peripheral and splanchnic glucose metabolism in non-insulin-dependent (type II) diabetes mellitus. J Clin Invest. 1985;76:149-155.
3. Eriksson J, Franssila-Kallunki A, Ekstrand A, et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med. 1989;321:337-343.
4. Warram JH, Martin BC, Krolewski AS, et al. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med. 1990;113:909-915.
5. Vaag A, Henriksen JE, Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscle in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1992;89:782-788.
6. Thorburn AW, Gumbiner B, Bulacan F, et al. Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus. J Clin Invest. 1991;87:489-495.
7. Vesterpaard H, Lund S, Larsen FS, et al. Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1993;91:2342-2350.
8. Andréasson K, Galuska D, Thörne A, et al. Decreased insulin-stimulated 3-O-methylglucose transport in in vitro incubated muscle strips from type II diabetic subjects. Acta Physiol Scand. 1991;142:255-260.
9. Zierath JR, Galuska D, Nolte L, et al. Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: in vitro reversal of muscular insulin resistance. Diabetologia. 1994;37:270-277.
10. White MF. Insulin signaling in health and disease. Science. 2003;302:1710-1711.
11. Arner P, Pollare T, Lithell H, et al. Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1987;30:437-440.
12. Nolan JJ, Freidenberg G, Henry R, et al. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab. 1994;78:471-477.
13. Maegawa H, Shigeta Y, Egawa K, et al. Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM. Diabetes. 1991;40:815-819.
14. Caro JF, Sinha MK, Raju SM, et al. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. J Clin Invest. 1987;79:1330-1337.
15. Klein HH, Vestergaard H, Kotzke G, et al. Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM. Diabetes. 1995;44:1310-1317.
16. Krook A, Björnholm M, Galuska D, et al. Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients. Diabetes. 2000;49:284-292.
17. Leng Y, Karlsson HK, Zierath JR. Insulin signaling defects in type 2 diabetes. Rev Endocr Metab Disord. 2004;5:111-117.
18. Qureshi SA, Ding V, Li Z, et al. Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators. J Biol Chem. 2000;275:36590-36595.
19. Zhang B, Salituro G, Szalkowski D, et al. Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science. 1999;284:974-977.
20. Al-Khalili L, Chibalin AV, Kannisto K, et al. Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content. Cell Mol Life Sci. 2003;60:991-998.
21. Virkamäki A, Ueki K, Kahn CR. Protein-protein interactions in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest. 1999;103:931-943.
22. Long YC, Widegren U, Zierath JR. Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. Proc Nutr Soc. 2004;63:227-232.
23. Watson RT, Shigematsu S, Chiang S-H, et al. Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. J Cell Biol. 2001;154:829-840.
24. Mitra P, Zheng X, Czech MP. RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin. J Biol Chem. 2004;279:37431-37435.
25. Molero JC, Jensen TE, Withers PC, et al. c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action. J Clin Invest. 2004;114:1326-1333.
26. Björnholm M, He AR, Attersand A, et al. Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans. Diabetologia. 2002;45:1697-1702.
27. Björnholm M, Kawano Y, Lehtihet M, et al. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity are decreased in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes. 1997;46:524-527.
28. Rondinone CM, Wang LM, Lönnroth P, et al. Insulin receptor substrate (1RS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A. 1997;94:4171-4175.
29. Carvalho E, Jansson PA, Nagaev I, et al. Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport. FASEB J. 2001;15:1101-1103.
30. -/ double knockout mice. Genes Dev. 2002;16:3213-3222.
31. Foukas LC, Shepherd PR. Phosphoinositide 3-kinase: the protein kinase that time forgot. Biochem Soc Trans. 2004;32(pt 2): 330-331.
32. Chen D, Mauvais-Jarvis F, Bluher M, et al. p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol. 2004;24:320-329.
33. Cusi K, Maezono K, Osman A, et al. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest. 2000;105:311-320.
34. Kim YB, Nikoulina SE, Ciaraldi TP, et al. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest. 1999;104:733-741.
35. Goodyear LJ, Giorgino F, Sherman LA, et al. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest. 1995;95:2195-2204.
36. Yeh J-I, Gulve EA, Rameh L, et al. The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport. J Biol Chem. 1995;270:2107-2111.
37. Lund S, Holman GD, Schmitz O, et al. Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. Proc Natl Acad Sci U S A. 1995;92:5817-5821.
38. Tsuchida H, Bjornholm M, Fernstrom M, et al. Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects. Pflugers Arch. 2002;445:25-31.
39. Fruman DA, Mauvais-Jarvis F, Pollard DA, et al. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nature Genetics. 2000;26:379-382.
40. Terauchi Y, Tsuji Y, Satoh S, et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nature Genetics. 1999;21:230-235.
41. Kohn AD, Summers SA, Birnbaum MJ, et al. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem. 1996;271:31372-31378.
42. Wang Q, Somwar R, Bilan PJ, et al. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol. 1999;19:4008-4018.
43. Jiang ZY, Zhou QL, Coleman KA, et al. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003;100:7569-7574.
44. Burgering BMT, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature. 1995;376:599-602.
45. Barthel A, Nakatani K, Dandekar AA, et al. Protein kinase C modulates the insulin-stimulated increase in Akt1 and Akt3 activity in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 1998;243:509-513.
46. Cross DA, Alessi DR, Cohen P, et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378:785-789.
47. Kane S, Sano H, Liu SCH, et al. A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem. 2002;27:22115-22118.
48. Sano H, Kane S, Sano E, et al. Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem. 2003;278:14599-14602.
49. Zeigerer A, McBrayer MK, McGraw TE. insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160. Mol Biol Cell. 2004;15:4406-4415.
50. Bruss MD, Arias EB, Lienhard GE, et al. Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity. Diabetes. 2005;54:41-50.
51. Cho H, Mu J, Kim JK, et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science. 2001;292:1728-1731.
52. Cho H, Thorvaldsen JL, Chu Q, et al. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem. 2001;276:38349-38352.
53. Krook A, Roth RA, Jiang XJ, et al. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes. 1998;47:1281-1286.
54. Brozinick JT Jr, Roberts BR, Dohm GL. Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Diabetes. 2003;52:935-941.
55. Gosmanov AR, Umpierrez GE, Karabell AH, et al. Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes. Am J Physiol Endocrinol Metab. 2004;287:E8-E15.
56. Meyer MM, Levin K, Grimmsmann T, et al. Insulin signalling in skeletal muscle of subjects with or without type II-diabetes and first degree relatives of patients with the disease. Diabetologia. 2002;45:813-822.
57. Song XM, Kawano Y, Krook A, et al. Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats. Diabetes. 1999;48:664-670.
58. Kurowski TG, Lin Y, Luo Z, et al. Hyperglycemia inhibits insulin activation of Akt/protein kinase B, but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes. 1999;48:658-663.
59. Krook A, Kawano Y, Song XM, et al. Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats. Diabetes. 1997;46:2110-2114.
60. Moller DE. New drug targets for type 2 diabetes and the metabolic syndrome. Nature. 2001;414:821-827.
61. Zierath JR. In vitro studies of human skeletal muscle. Hormonal and metabolic regulation of glucose transport. Acta Physiol Scand Suppl. 1995;626:1-96.