메뉴 건너뛰기




Volumn 12, Issue 5, 2006, Pages 526-531

Genetic and environmental origins of obesity relevant to reproduction

Author keywords

Androgens; Anovulation; Candidate genes; Complex trait; Insulin resistance; Polycystic ovarian syndrome (PCOS)

Indexed keywords

ANDROGEN; INSULIN; INSULIN RECEPTOR;

EID: 33646417382     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1472-6483(10)61177-7     Document Type: Article
Times cited : (45)

References (60)
  • 2
    • 0036313064 scopus 로고    scopus 로고
    • Developmental origin of polycystic ovary syndrome - A hypothesis
    • Abbott DH, Dumesic DA, Franks S 2002 Developmental origin of polycystic ovary syndrome - a hypothesis. Journal of Endocrinology 174, 1-5.
    • (2002) Journal of Endocrinology , vol.174 , pp. 1-5
    • Abbott, D.H.1    Dumesic, D.A.2    Franks, S.3
  • 3
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARgamma Pro12A1a polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M et al. 2000 The common PPARgamma Pro12A1a polymorphism is associated with decreased risk of type 2 diabetes. Nature Genetics 26, 76-80.
    • (2000) Nature Genetics , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 5
    • 0005166463 scopus 로고    scopus 로고
    • Morphological differences in preantral follicle distribution between normal and androgenised ovine ovaries
    • Birch R, Robinson JE, Hardy K, Franks S 2001 Morphological differences in preantral follicle distribution between normal and androgenised ovine ovaries. Endocrine Abstracts 2, P74.
    • (2001) Endocrine Abstracts , vol.2
    • Birch, R.1    Robinson, J.E.2    Hardy, K.3    Franks, S.4
  • 6
    • 0035257236 scopus 로고    scopus 로고
    • Association study designs for complex diseases
    • Cardon LR, Bell JI 2001 Association study designs for complex diseases. Nature Reviews Genetics 2, 91-99.
    • (2001) Nature Reviews Genetics , vol.2 , pp. 91-99
    • Cardon, L.R.1    Bell, J.I.2
  • 7
    • 0027196489 scopus 로고
    • Evidence for a single gene effect causing polycystic ovaries and male pattern baldness
    • Carey AH, Chan KL, Short F et al. 1993 Evidence for a single gene effect causing polycystic ovaries and male pattern baldness. Clinical Endocrinology (Oxford) 38, 653-658.
    • (1993) Clinical Endocrinology (Oxford) , vol.38 , pp. 653-658
    • Carey, A.H.1    Chan, K.L.2    Short, F.3
  • 9
    • 0031835060 scopus 로고    scopus 로고
    • Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment
    • Clark AM, Thornley B, Tomlinson L et al. 1998 Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Human Reproduction 13, 1502-1505.
    • (1998) Human Reproduction , vol.13 , pp. 1502-1505
    • Clark, A.M.1    Thornley, B.2    Tomlinson, L.3
  • 10
    • 0028843928 scopus 로고
    • Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women
    • Clark AM, Ledger W, Galletly C et al. 1995 Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Human Reproduction 10, 2705-2712.
    • (1995) Human Reproduction , vol.10 , pp. 2705-2712
    • Clark, A.M.1    Ledger, W.2    Galletly, C.3
  • 11
    • 0028132564 scopus 로고
    • The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinaemia and polycystic ovary syndrome
    • Conway GS, Avey C, Rumsby G 1994 The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinaemia and polycystic ovary syndrome. Human Reproduction 9, 1681-1683.
    • (1994) Human Reproduction , vol.9 , pp. 1681-1683
    • Conway, G.S.1    Avey, C.2    Rumsby, G.3
  • 12
    • 27744585694 scopus 로고    scopus 로고
    • Genetics of polycystic ovary syndrome: Searching for the way out of the labyrinth
    • Diamanti-Kandarakis E, Piperi C 2005 Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth. Human Reproduction Update 11, 631-643.
    • (2005) Human Reproduction Update , vol.11 , pp. 631-643
    • Diamanti-Kandarakis, E.1    Piperi, C.2
  • 13
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif A 1997 Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews 18, 774-800.
    • (1997) Endocrine Reviews , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 14
    • 0032952468 scopus 로고    scopus 로고
    • Freely associating
    • Editorial
    • Editorial 1999 Freely associating. Nature Genetics 22, 1-2.
    • (1999) Nature Genetics , vol.22 , pp. 1-2
  • 15
  • 16
    • 0036739962 scopus 로고    scopus 로고
    • Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome
    • Ehrmann DA, Tang X, Yoshiuchi I et al. 2002b Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 87, 4297-4300.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 4297-4300
    • Ehrmann, D.A.1    Tang, X.2    Yoshiuchi, I.3
  • 17
    • 0035461406 scopus 로고    scopus 로고
    • Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome
    • El Mkadem SA, Lautier C, Macari F et al. 2001 Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome. Diabetes 50, 2164-2168.
    • (2001) Diabetes , vol.50 , pp. 2164-2168
    • El Mkadem, S.A.1    Lautier, C.2    Macari, F.3
  • 18
    • 17044370727 scopus 로고    scopus 로고
    • The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome
    • Escobar-Morreale HF, Luque-Ramirez M, San Millan JL 2005 The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome. Endocrine Reviews 26, 251-282.
    • (2005) Endocrine Reviews , vol.26 , pp. 251-282
    • Escobar-Morreale, H.F.1    Luque-Ramirez, M.2    San Millan, J.L.3
  • 19
  • 20
    • 0035514934 scopus 로고    scopus 로고
    • Partial leptin deficiency and human adiposity
    • Farooqi IS, Keogh JM, Kamath S et al. 2001 Partial leptin deficiency and human adiposity. Nature 414, 34-35.
    • (2001) Nature , vol.414 , pp. 34-35
    • Farooqi, I.S.1    Keogh, J.M.2    Kamath, S.3
  • 25
    • 0031434341 scopus 로고    scopus 로고
    • The genetic basis of polycystic ovary syndrome
    • Franks S, Gharani N, Waterworth D, et al. 1997 The genetic basis of polycystic ovary syndrome. Human Reproduction 12, 2641-2648.
    • (1997) Human Reproduction , vol.12 , pp. 2641-2648
    • Franks, S.1    Gharani, N.2    Waterworth, D.3
  • 28
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR et al. 2003 Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52, 568-572.
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3
  • 29
    • 18444367986 scopus 로고    scopus 로고
    • Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome
    • Haddad L, Evans JC, Gharani N et al. 2002 Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 87, 2606-2610.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 2606-2610
    • Haddad, L.1    Evans, J.C.2    Gharani, N.3
  • 30
    • 0036170755 scopus 로고    scopus 로고
    • Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene
    • Hara M, Alcoser SY, Qaadir A et al. 2002 Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene. Journal of Clinical Endocrinology and Metabolism 87, 772-775.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 772-775
    • Hara, M.1    Alcoser, S.Y.2    Qaadir, A.3
  • 31
    • 0018343872 scopus 로고
    • The association of obesity with infertility and related menstrual abnormalities in women
    • Hartz AJ, Barboriak PN, Wong A et al. 1979 The association of obesity with infertility and related menstrual abnormalities in women. International Journal of Obesity 3, 57-73.
    • (1979) International Journal of Obesity , vol.3 , pp. 57-73
    • Hartz, A.J.1    Barboriak, P.N.2    Wong, A.3
  • 33
    • 0031769471 scopus 로고    scopus 로고
    • Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: Relation to reduced fetal growth
    • Ibanez L, Potau N, Francois I, de Zegher F 1998 Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth. Journal of Clinical Endocrinology and Metabolism 83, 3558-3562.
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , pp. 3558-3562
    • Ibanez, L.1    Potau, N.2    Francois, I.3    de Zegher, F.4
  • 34
    • 0030949271 scopus 로고    scopus 로고
    • Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
    • Jackson RS, Creemers JW, Ohagi S et al. 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nature Genetics 16, 303-306.
    • (1997) Nature Genetics , vol.16 , pp. 303-306
    • Jackson, R.S.1    Creemers, J.W.2    Ohagi, S.3
  • 35
    • 0026543775 scopus 로고
    • Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome
    • Kiddy DS, Hamilton-Fairley D, Bush A et al. 1992 Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clinical Endocrinology (Oxford) 36, 105-111.
    • (1992) Clinical Endocrinology (Oxford) , vol.36 , pp. 105-111
    • Kiddy, D.S.1    Hamilton-Fairley, D.2    Bush, A.3
  • 36
    • 0025092087 scopus 로고
    • Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: An analysis of 263 consecutive cases
    • Kiddy DS, Sharp PS, White DM, Scanlon et al. 1990 Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: an analysis of 263 consecutive cases. Clinical Endocrinology (Oxford) 32, 213-220.
    • (1990) Clinical Endocrinology (Oxford) , vol.32 , pp. 213-220
    • Kiddy, D.S.1    Sharp, P.S.2    White, D.M.3    Scanlon4
  • 42
    • 8744317100 scopus 로고    scopus 로고
    • Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome
    • Maciel GA, Baracat EC, Benda JA et al. 2004 Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 89, 5321-5327.
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 5321-5327
    • Maciel, G.A.1    Baracat, E.C.2    Benda, J.A.3
  • 43
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague CT, Farooqi IS, Whitehead JP et al. 1997 Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3
  • 45
    • 21044440251 scopus 로고    scopus 로고
    • Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits
    • Powell BL, Haddad L, Bennett A et al. 2005 Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits. Journal of Clinical Endocrinology and Metabolism 90, 2988-2993.
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , pp. 2988-2993
    • Powell, B.L.1    Haddad, L.2    Bennett, A.3
  • 46
    • 0026647068 scopus 로고
    • Postprandial thermogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance
    • Robinson S, Chan SP, Spacey S et al. 1992 Postprandial thermogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance. Clinical Endocrinology (Oxford) 36, 537-543.
    • (1992) Clinical Endocrinology (Oxford) , vol.36 , pp. 537-543
    • Robinson, S.1    Chan, S.P.2    Spacey, S.3
  • 49
    • 0029858544 scopus 로고    scopus 로고
    • The TDT and other family-based tests for linkage disequilibrium and association
    • Spielman RS, Ewens WJ 1996 The TDT and other family-based tests for linkage disequilibrium and association. American Journal of Human Genetics 59, 983-989.
    • (1996) American Journal of Human Genetics , vol.59 , pp. 983-989
    • Spielman, R.S.1    Ewens, W.J.2
  • 51
    • 0035142308 scopus 로고    scopus 로고
    • Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus
    • Tucci S, Futterweit W, Concepcion ES et al. 2001 Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus. Journal of Clinical Endocrinology and Metabolism 86, 446-449.
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , pp. 446-449
    • Tucci, S.1    Futterweit, W.2    Concepcion, E.S.3
  • 53
    • 0037219110 scopus 로고    scopus 로고
    • Variation in resistin gene promoter not associated with polycystic ovary syndrome
    • Urbanek M, Du Y, Silander K et al. 2003 Variation in resistin gene promoter not associated with polycystic ovary syndrome. Diabetes 52, 214-217.
    • (2003) Diabetes , vol.52 , pp. 214-217
    • Urbanek, M.1    Du, Y.2    Silander, K.3
  • 55
    • 0037227264 scopus 로고    scopus 로고
    • Association between the D19S884 marker at the insulin receptor gene locus and polycystic ovary syndrome
    • Villuendas G, Escobar-Morreale HF, Tosi F et al. 2003 Association between the D19S884 marker at the insulin receptor gene locus and polycystic ovary syndrome. Fertility and Sterility 79, 219-220.
    • (2003) Fertility and Sterility , vol.79 , pp. 219-220
    • Villuendas, G.1    Escobar-Morreale, H.F.2    Tosi, F.3
  • 57
    • 0030895556 scopus 로고    scopus 로고
    • Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome
    • Waterworth DM, Bennett ST, Gharani N et al. 1997 Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet 349, 986-990.
    • (1997) Lancet , vol.349 , pp. 986-990
    • Waterworth, D.M.1    Bennett, S.T.2    Gharani, N.3
  • 58
    • 0141537231 scopus 로고    scopus 로고
    • Formation and early development of follicles in the polycystic ovary
    • Webber LJ, Stubbs S, Stark J et al. 2003 Formation and early development of follicles in the polycystic ovary. Lancet 362, 1017-1021.
    • (2003) Lancet , vol.362 , pp. 1017-1021
    • Webber, L.J.1    Stubbs, S.2    Stark, J.3
  • 59
    • 0029795318 scopus 로고    scopus 로고
    • Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: An analysis of 109 pregnancies in 225 women
    • White DM, Polson DW, Kiddy D et al. 1996 Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women. Journal of Clinical Endocrinology and Metabolism 81, 3821-3824.
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , pp. 3821-3824
    • White, D.M.1    Polson, D.W.2    Kiddy, D.3
  • 60
    • 0038374441 scopus 로고    scopus 로고
    • The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis
    • Wood JR, Nelson VL, Ho C et al. 2003 The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. Journal of Biological Chemistry 278, 26380-26390.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 26380-26390
    • Wood, J.R.1    Nelson, V.L.2    Ho, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.