Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 25, 1998, Pages 14956-14960

  Legro, Richard S ^a   Driscoll, Deborah ^b   Strauss III, Jerome F ^b   Fox, Janis ^c   Dunaif, Andrea ^c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; HORMONE BINDING PROTEIN; LUTEINIZING HORMONE; TESTOSTERONE;

ANDROGEN BLOOD LEVEL; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC APPROACH ROUTE; FAMILIAL DISEASE; FAMILY STUDY; FEMALE; GENETIC LINKAGE; HEREDITY; HUMAN; HYPERANDROGENISM; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OLIGOMENORRHEA; OVARY POLYCYSTIC DISEASE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERANDROGENISM; LINKAGE (GENETICS); MIDDLE AGED; POLYCYSTIC OVARY SYNDROME;

EID: 0032428506     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.25.14956     Document Type: Article

References (30)

1. Legro, R. S., Spielman, R., Urbanek, M., Driscoll, D., Strauss, J. S. & Dunaif, A. (1998) Recent Prog. Horm. Res. 53, 217-256.
2. Franks, S., Gharani, N., Waterworth, D., Batty, S., White, D., Williamson, R. & McCarthy, M. (1997) Hum. Reprod. 12, 2641-2648.
3. Ferriman, D. & Purdie, A. W. (1979) Clin. Endocrinol. (Oxford) 11, 291-300.
4. Lunde, O., Magnus, P., Sandvik, L. & Hoglo, S. (1989) Gynecol. Obstet. Invest. 28, 23-30.
5. Lander, E. S. & Schork, N. J. (1994) Science 265, 2037-2048.
6. Jahanfar, S., Eden, J. A., Warren, P., Seppala, M. & Nguyen, T. V. (1995) Fertil. Steril. 63, 478-486.
7. Carey, A. H., Chan, K. L., Short, F., White, D., Williamson, R. & Franks, S. (1993) Clin. Endocrinol. 38, 653-658.
8. Adams, J., Poison, D. W. & Franks, S. (1986) Br. Med. J. 293, 355-359.
9. Polson, D. W., Adams, J., Wadsworth, J. & Franks, S. (1988) Lancet 1, 870-872.
10. Dunaif, A. (1997) Endocr. Rev. 18, 774-800.
11. Hatch, R., Rosenfield, R. L., Kim, M. H. & Tredway, D. (1981) Am. J. Obstet. Gynecol. 140, 815-830.
12. World Health Organization (1980) WHO Expert Committee on Diabetes Mellitus: Second Report (Technical Report Series 626, World Health Organization, Geneva).
13. Zawadski, J. K. & Dunaif, A. (1992) The Polycystic Ovary Syndrome, eds. Givens, J. R., Haseltine, F. & Merriam, G. R. (Blackwell Scientific, Oxford), pp. 377-384.
14. Dunaif, A., Scott, D., Finegood, D., Quintana, B. & Whitcomb, R. (1996) J. Clin. Endocrinol. Metab. 81, 3299-3306.
15. Tremblay, R. R. & Dube, J. Y. (1974) Contraception 10, 599-605.
16. Givens, J. R., Andersen, R. N., Wiser, W. L. & Fish, S. A. (1974) J. Clin. Endocrinol. Metab. 38, 727-735.
17. Nestler, J. E. & Jakubowicz, D. J. (1996) N. Eng. J. Med. 335, 617-623.
18. Beer, N. A., Jacubowicz, D. J., Beer, R. M. & Nestler, J. E. (1994) J. Clin. Endocrinol. Metab. 79, 1077-1081.
19. Erhmann, D. A., Barnes, R. B., Rosenfield, R. L. (1995) Endocr. Rev. 16, 322-353.
20. Weinshilboum, R. & Raymond, F. A. (1977) Am. J. Hum. Genet. 29, 125-135.
21. Santen, R. J. & Bardin, C. W. (1973) J. Clin. Invest. 52, 2617-2628.
22. Lee, P. A., Migeon, C. J., Bias, W. B. & Jones, G. S. (1987) Obstet. Gynecol. 69, 259-264.
23. Hague, W. M., Adams, J., Reeders, S. T., Peto, T. E. & Jacobs, H. S. (1988) Clin. Endocrinol. 29, 593-605.
24. Farquhar, C. M., Birdsall, M., Manning, P., Mitchell, J. M. & France, J. T. (1994) Aust. N. Z. J. Obstet. Gynecol. 34, 67-72.
25. Norman, R. J., Masters, S. & Hague, W. (1996) Fertil. Steril. 66, 942-947.
26. Knochenhauer, E. S., Key, T. J., Kahsar-Miller, M., Waggoner, W., Boots, L. R. & Azziz, R. (1998) J. Clin. Endocrinol. Metab. 83, 3078-3082.
27. Ghosh, S. & Shork, N. J. (1996) Diabetes 45, 1-14.
28. White, D., Leigh, A., Wilson, C., Donaldson, A. & Franks, S. (1995) Clin. Endocrinol. 42, 475-481.
29. Adams, J., Franks, S., Polson, D. W., Mason, H. D., Abdulwahid, U., Tucker, M., Price, J. & Jacobs, H. S. (1985) Lancet 2, 1375-1379.
30. Cox, N. J., Xiang, K. S., Fajans, S. S. & Bell, G. I. (1992) Diabetes 41, 401-407.