Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment

Human Reproduction

Volumn 13, Issue 6, 1998, Pages 1502-1505

  Clark, A M ^a,b   Thornley, B ^a   Tomlinson, L ^a   Galletley, C ^a   Norman, R J ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b Hurstville Community Hospital   (Australia)

Author keywords

Obesity; Ovulation; Pregnancy; Self esteem; Weight loss

Indexed keywords

ADULT; ARTICLE; BIRTH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST CONTROL; DIET; EXERCISE; FEMALE; FEMALE INFERTILITY; HEALTH CARE COST; HUMAN; INFERTILITY THERAPY; LIFESTYLE; MAJOR CLINICAL STUDY; OBESITY; OVULATION; PREGNANCY RATE; PROSPECTIVE STUDY; PSYCHOMETRY; REPRODUCTION; SPONTANEOUS ABORTION; WEIGHT REDUCTION;

EID: 0031835060     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.6.1502     Document Type: Article

References (15)

1. Chong, A.P., Rafael, R.W. and Forte, C.C. (1986) Influence of weight in the induction of ovulation with human menopausal gonadotropin and human chorionic gonadotropin. Fertil. Steril., 46, 599-603.
2. Clark, A.M., Ledger, W., Galletly, C. et al. (1995) Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum. Reprod., 10, 2705-2712.
3. Crosignani, P.G., Ragni, G., Parazzini, F. et al. (1994) Anthropometric indicators and response to gonadotropin for ovulation induction. Hum. Reprod., 9, 420-423.
4. Domar, A.D., Seibel, M.M. and Benson, H. (1990) The Mind/Body Program for Infertility: a new behavioural treatment approach for women with infertility. Fenil. Steril., 53, 246-249.
5. Guzick, D.S., Wing, R., Smith, D. et al. (1994) Endocrine consequences of weight loss in obese, hyperandrogenic, anovulatory women. Fertil. Steril., 61, 598-604.
6. Hamilton-Fairley, D., Kiddy, D., Watson, H. et al. (1992) Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin. Br. J. Obstet. Gynaecol., 99, 128-131.
7. Harlow, C.R., Fahy, U.M., Talbot, W.M. et al. (1996) Stress and stress-related hormones during in-vitro fertilization treatment. Hum. Reprod., 11, 274-279.
8. Helman, M., Runnebaum, B. and Gerhard T. (1996) Effects of weight loss on the hormonal profile in obese infertile women. Hum. Reprod., 11, 1884-1891.
9. McClure, N., McQuinn, B., McDonald, J. et al. (1992) Body weight, body mass index, and age: predictors of menotropin dose and cycle outcome in polycystic ovarian syndrome? Fertil. Steril., 58, 622-624.
10. Rookus, M.A., Burema, J., Hol Van, M.A. et al. (1987) The development of body mass index in young adults. II. Interrelationships of level, change and fluctuation, a four-year longitudinal study. Hum. Biol., 59, 617-630.
11. Stunkard, A.J., Craighead, L.W. and O'Brien, R. (1980) Controlled trial of behaviour therapy, pharmacotherapy and their combination in the treatment of obesity. Lancet, 2, 1045-1047.
12. Thiering, P., Beaurepaire, J., Jones, M. et al. (1993) Mood state as a predictor of treatment outcome after in vitro fertilisation/embryo transfer technology (IVF/ET). J. Psychosomat. Res., 37, 481-491.
13. Velazquez, E.M., Mendoza, S., Hamer, T. et al. (1994) Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism, 43, 647-654.
14. Waller, D.K., Mills, J.L., Simpson, J.L. et al. (1994) Are obese women at higher risk for producing malformed offspring? Am. J. Obstet. Gynecol., 170, 541-548.
15. Zaadstra, B.M., Seidell, J.C., Van Noord, P.A.H. et al. (1993) Fat and female fecundity: prospective study of effect of body fat distribution on conception rates. Br. Med. J., 306, 484-487.