Crystal structure of yeast cytosine deaminase: Insights into enzyme mechanism and evolution

Journal of Biological Chemistry

Volumn 278, Issue 21, 2003, Pages 19111-19117

  Ko, Tzu Ping ^a   Lin, Jing Jer ^b   Hu, Chih Yung ^b   Hsu, Yi Hsin ^b   Wang, Andrew H J ^a   Liaw, Shwu Huey ^b,c  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; DIMERS; ENZYMES; MONOMERS; TUMORS;

GENE THERAPY;

YEAST;

2 HYDROXYPYRIMIDINE; 5 AMINOIMIDAZOLE 4 CARBOXAMIDE RIBONUCLEOTIDE TRANSFORMYLASE; CYTOSINE DEAMINASE; ENZYME INHIBITOR; RIBONUCLEOTIDE; UNCLASSIFIED DRUG; 2-HYDROXYPYRIMIDINE; ANTINEOPLASTIC AGENT; DEAMINASE; FLUCYTOSINE; FLUOROURACIL; PYRIMIDINE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHIRALITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEAMINATION; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE THERAPY; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; YEAST; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; ENZYMOLOGY; ESCHERICHIA COLI; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; STEREOISOMERISM;

BACTERIA (MICROORGANISMS); PHOCIDAE;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; BINDING SITES; CATALYSIS; CRYSTALLIZATION; CYTOSINE DEAMINASE; DIMERIZATION; ENZYME INHIBITORS; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; FLUCYTOSINE; FLUOROURACIL; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEOSIDE DEAMINASES; PYRIMIDINES; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0038482076     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300874200     Document Type: Article

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