Vitamins C and E attenuate apoptosis, β-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction

Free Radical Biology and Medicine

Volumn 40, Issue 10, 2006, Pages 1827-1842

  Qin, Fuzhong ^a   Yan, Chen ^a   Patel, Ravish ^a   Liu, Weimin ^a   Dong, Erdan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Apoptosis; Free radical; Heart failure; Myocardial infarction; Oxidative stress; Remodeling; Sarcoplasmic reticular Ca2+ ATPase; Signal transduction

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA ADRENERGIC RECEPTOR; CASPASE 3; CASPASE 9; CYTOCHROME C; ISOPRENALINE; MITOCHONDRIAL PROTEIN; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME ACTIVITY; ENZYME RELEASE; HEART DILATATION; HEART DISEASE; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART VENTRICLE CONTRACTILITY; HEART VENTRICLE PRESSURE; HEART VENTRICLE REMODELING; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY; SARCOPLASMIC RETICULUM;

ANIMALS; APOPTOSIS; ASCORBIC ACID; BLOTTING, WESTERN; CALCIUM-TRANSPORTING ATPASES; DOWN-REGULATION; ECHOCARDIOGRAPHY; HEART FAILURE, CONGESTIVE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MITOCHONDRIA; MUSCLE CELLS; MYOCARDIAL INFARCTION; OXIDATIVE STRESS; RABBITS; RECEPTORS, ADRENERGIC, BETA; SARCOPLASMIC RETICULUM; VENTRICULAR REMODELING; VITAMIN E; VITAMINS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33646136216     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.01.019     Document Type: Article

References (72)

1. Li W.G., Zaheer A., Coppey L., and Oskarsson H.J. Activation of JNK in the remote myocardium after large myocardial infarction in rats. Biochem. Biophys. Res. Commun. 246 (1998) 816-820
2. Ferrari R., Guardigli G., Mele D., Percoco G.F., Ceconi C., and Curello S. Oxidative stress during myocardial ischaemia and heart failure. Curr. Pharm. Des. 10 (2004) 1699-1711
3. Qin F., Liang M.C., and Liang C.S. Progressive left ventricular remodeling, myocyte apoptosis and protein signaling cascades after myocardial infarction in rabbits. Biochim. Biophys. Acta 1740 (2005) 499-513
4. Sawyer D.B., Siwik D.A., Xiao L., Pimentel D.R., Singh K., and Colucci W.S. Role of oxidative stress in myocardial hypertrophy and failure. J. Mol. Cell. Cardiol. 34 (2002) 379-388
5. Liu Q., and Hofmann P.A. Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H2204-H2212
6. von Harsdorf R., Li P.F., and Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 99 (1999) 2934-2941
7. Sam F., Sawyer D.B., Chang D.L., Eberli F.R., Ngoy S., Jain M., Amin J., Apstein C.S., and Colucci W.S. Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart. Am. J. Physiol. Heart Circ. Physiol. 279 (2000) H422-H428
8. Palojoki E., Saraste A., Eriksson A., Pulkki K., Kallajoki M., Voipio-Pulkki L.M., and Tikkanen I. Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats. Am. J. Physiol. Heart Circ. Physiol. 280 (2001) H2726-H2731
9. Baldi A., Abbate A., Bussani R., Patti G., Melfi R., Angelini A., Dobrina A., Rossiello R., Silvestri F., Baldi F., and Di Sciascio G. Apoptosis and post-infarction left ventricular remodeling. J. Mol. Cell. Cardiol. 34 (2002) 165-174
10. Akyurek O., Akyurek N., Sayin T., Dincer I., Berkalp B., Akyol G., Ozenci M., and Oral D. Association between the severity of heart failure and the susceptibility of myocytes to apoptosis in patients with idiopathic dilated cardiomyopathy. Int. J. Cardiol. 80 (2001) 29-36
11. Chandrashekhar Y., Sen S., Anway R., Shuros A., and Anand I. Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction. J. Am. Coll. Cardiol. 43 (2004) 295-301
12. Oskarsson H.J., Coppey L., Weiss R.M., and Li W.G. Antioxidants attenuate myocyte apoptosis in the remote non-infarcted myocardium following large myocardial infarction. Cardiovasc. Res. 45 (2000) 679-687
13. Hare J.M. Oxidative stress and apoptosis in heart failure progression. Circ. Res. 89 (2001) 198-200
14. Li W.G., Coppey L., Weiss R.M., and Oskarsson H.J. Antioxidant therapy attenuates JNK activation and apoptosis in the remote noninfarcted myocardium after large myocardial infarction. Biochem. Biophys. Res. Commun. 280 (2001) 353-357
15. Qin F., Shite J., and Liang C.S. Antioxidants attenuate myocyte apoptosis and improve cardiac function in CHF: association with changes in MAPK pathways. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H822-H832
16. Rossig L., Hoffmann J., Hugel B., Mallat Z., Haase A., Freyssinet J.M., Tedgui A., Aicher A., Zeiher A.M., and Dimmeler S. Vitamin C inhibits endothelial cell apoptosis in congestive heart failure. Circulation 104 (2001) 2182-2187
17. Han H., Long H., Wang H., Wang J., Zhang Y., and Wang Z. Progressive apoptotic cell death triggered by transient oxidative insult in H9c2 rat ventricular cells: a novel pattern of apoptosis and the mechanisms. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H2169-H2182
18. Fu Y.C., Chi C.S., Yin S.C., Hwang B., Chiu Y.T., and Hsu S.L. Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway. Cardiovasc. Res. 62 (2004) 558-567
19. Shite J., Qin F., Mao W., Kawai H., Stevens S.Y., and Liang C. Antioxidant vitamins attenuate oxidative stress and cardiac dysfunction in tachycardia-induced cardiomyopathy. J. Am. Coll. Cardiol. 38 (2001) 1734-1740
20. Lai L.P., Raju V.S., Delehanty J.M., Yatani A., and Liang C.S. Altered sarcoplasmic reticulum Ca2+ ATPase gene expression in congestive heart failure: effect of chronic norepinephrine infusion. J. Mol. Cell. Cardiol. 30 (1998) 175-185
21. Ahlers B.A., Song J., Wang J., Zhang X.Q., Carl L.L., Tadros G.M., Rothblum L.I., and Cheung J.Y. Effects of sarcoplasmic reticulum Ca2+-ATPase overexpression in postinfarction rat myocytes. J. Appl. Physiol. 98 (2005) 2169-2176
22. Siwik D.A., Tzortzis J.D., Pimental D.R., Chang D.L., Pagano P.J., Singh K., Sawyer D.B., and Colucci W.S. Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro. Circ. Res. 85 (1999) 147-153
23. Temsah R.M., Netticadan T., Chapman D., Takeda S., Mochizuki S., and Dhalla N.S. Alterations in sarcoplasmic reticulum function and gene expression in ischemic-reperfused rat heart. Am. J. Physiol. 277 (1999) H584-H594
24. Gare M., Mraovic B., Kehl F., Kersten J.R., Warltier D.C., and Pagel P.S. Reactive oxygen species contribute to contractile dysfunction following rapid ventricular pacing in dogs. Int. J. Cardiol. 83 (2002) 125-131
25. Yusuf S., Dagenais G., Pogue J., Bosch J., and Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N. Engl. J. Med. 342 (2000) 154-160
26. Lonn E., Bosch J., Yusuf S., Sheridan P., Pogue J., Arnold J.M., Ross C., Arnold A., Sleight P., Probstfield J., and Dagenais G.R. HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 293 (2005) 1338-1347
27. Lee I.M., Cook N.R., Gaziano J.M., Gordon D., Ridker P.M., Manson J.E., Hennekens C.H., and Buring J.E. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 294 (2005) 56-65
28. Jaxa-Chamiec T., Bednarz B., Drozdowska D., Gessek J., Gniot J., Janik K., Kawka-Urbanek T., Maciejewski P., Ogorek M., Szpajer M., and MIVIT Trial Group. Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot myocardial infarction and VITamins (MIVIT) trial. Kardiol. Pol. 62 (2005) 344-350
29. Pennock G.D., Yun D.D., Agarwal P.G., Spooner P.H., and Goldman S. Echocardiographic changes after myocardial infarction in a model of left ventricular diastolic dysfunction. Am. J. Physiol. 273 (1997) H2018-H2029
30. Fletcher P.J., Pfeffer J.M., Pfeffer M.A., and Braunwald E. Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function. Circ. Res. 49 (1981) 618-626
31. Senthil S., Veerappan R.M., Ramakrishna Rao M., and Pugalendi K.V. Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction. Clin. Chim. Acta 348 (2004) 131-137
32. Hong S.Y., Hwang K.Y., Lee E.Y., Eun S.W., Cho S.R., Han C.S., Park Y.H., and Chang S.K. Effect of vitamin C on plasma total antioxidant status in patients with paraquat intoxication. Toxicol. Lett. 126 (2002) 51-59
33. Keith M., Geranmayegan A., Sole M.J., Kurian R., Robinson A., Omran A.S., and Jeejeebhoy K.N. Increased oxidative stress in patients with congestive heart failure. J. Am. Coll. Cardiol. 31 (1998) 1352-1356
34. Mezzetti A., Lapenna D., Pierdomenico S.D., Calafiore A.M., Costantini F., Riario-Sforza G., Imbastaro T., Neri M., and Cuccurullo F. Vitamins E, C and lipid peroxidation in plasma and arterial tissue of smokers and non-smokers. Atherosclerosis 112 (1995) 91-99
35. Zhou J.F., Cai D., and Tong G.Z. Oxidative stress and potential free radical damage associated with photocopying. A role for ozone?. Free Radic. Res. 37 (2003) 137-143
36. Lee C.Y., and Man-Fan Wan J. Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian men and women. J. Nutr. 130 (2000) 2932-2937
37. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106 (1980) 207-212
38. Pat B., Yang T., Kong C., Watters D., Johnson D.W., and Gobe G. Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants. Kidney Int. 67 (2005) 931-943
39. Liu Y.H., Carretero O.A., Cingolani O.H., Liao T.D., Sun Y., Xu J., Li L.Y., Pagano P.J., Yang J.J., and Yang X.P. Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H2616-H2623
40. Frankfurt O.S., Robb J.A., Sugarbaker E.V., and Villa L. Apoptosis in breast carcinomas detected with monoclonal antibody to single-stranded DNA: relation to bcl-2 expression, hormone receptors, and lymph node metastases. Clin. Cancer Res. 3 (1997) 465-471
41. Phaneuf S., and Leeuwenburgh C. Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282 (2002) R423-R430
42. Sia Y.T., Parker T.G., Liu P., Tsoporis J.N., Adam A., and Rouleau J.L. Improved post-myocardial infarction survival with probucol in rats: effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression. J. Am. Coll. Cardiol. 39 (2002) 148-156
43. Tsutsui H., Ide T., Shiomi T., Kang D., Hayashidani S., Suematsu N., Wen J., Utsumi H., Hamasaki N., and Takeshita A. 8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts. Circulation 104 (2001) 2883-2885
44. Ide T., Tsutsui H., Hayashidani S., Kang D., Suematsu N., Nakamura K., Utsumi H., Hamasaki N., and Takeshita A. Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ. Res. 88 (2001) 529-535
45. Cheng W., Li B., Kajstura J., Li P., Wolin M.S., Sonnenblick E.H., Hintze T.H., Olivetti G., and Anversa P. Stretch-induced programmed myocyte cell death. J. Clin. Invest. 96 (1995) 2247-2259
46. de Jong J.W., Schoemaker R.G., de Jonge R., Bernocchi P., Keijzer E., Harrison R., Sharma H.S., and Ceconi C. Enhanced expression and activity of xanthine oxidoreductase in the failing heart. J. Mol. Cell. Cardiol. 32 (2000) 2083-2089
47. Sia Y.T., Lapointe N., Parker T.G., Tsoporis J.N., Deschepper C.F., Calderone A., Pourdjabbar A., Jasmin J.F., Sarrazin J.F., Liu P., Adam A., Butany J., and Rouleau J.L. Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat. Circulation 105 (2002) 2549-2555
48. Kinugawa S., Tsutsui H., Hayashidani S., Ide T., Suematsu N., Satoh S., Utsumi H., and Takeshita A. Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress. Circ. Res. 87 (2000) 392-398
49. Feuerstein G.Z., and Young P.R. Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways. Cardiovasc. Res. 45 (2000) 560-569
50. Childs A.C., Phaneuf S.L., Dirks A.J., Phillips T., and Leeuwenburgh C. Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio. Cancer Res. 62 (2002) 4592-4598
51. Cheng W., Kajstura J., Nitahara J.A., Li B., Reiss K., Liu Y., Clark W.A., Krajewski S., Reed J.C., Olivetti G., and Anversa P. Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp. Cell. Res. 226 (1996) 316-327
52. Misao J., Hayakawa Y., Ohno M., Kato S., Fujiwara T., and Fujiwara H. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation 94 (1996) 1506-1512
53. Narula J., Pandey P., Arbustini E., Haider N., Narula N., Kolodgie F.D., Dal Bello B., Semigran M.J., Bielsa-Masdeu A., Dec G.W., Israels S., Ballester M., Virmani R., Saxena S., and Kharbanda S. Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. Proc. Natl. Acad. Sci. USA 96 (1999) 8144-8149
54. Scheubel R.J., Bartling B., Simm A., Silber R.E., Drogaris K., Darmer D., and Holtz J. Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium: fragile balance of myocyte survival?. J. Am. Coll. Cardiol. 39 (2002) 481-488
55. Guaiquil V.H., Golde D.W., Beckles D.L., Mascareno E.J., and Siddiqui M.A. Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts. Free Radic. Biol. Med. 37 (2004) 1419-1429
56. Qin F., Rounds N.K., Mao W., Kawai K., and Liang C.S. Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets. Cardiovasc. Res. 51 (2001) 736-748
57. Anversa P., Olivetti G., and Capasso J.M. Cellular basis of ventricular remodeling after myocardial infarction. Am. J. Cardiol. 68 (1991) 7D-16D
58. Beltrami C.A., Fianto N., Rocco M., Feruglio G.A., Puricelli C., Cigola E., Quaini F., Sonnenblick E.H., Olivetti G., and Anversa P. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation 89 (1994) 151-163
59. Guerra S., Leri A., Wang X., Finato N., Di Loreto C., Beltrami C.A., Kajstura J., and Anversa P. Myocyte death in the failing human heart is gender dependent. Circ. Res. 85 (1999) 856-866
60. Kostin S., Pool L., Elsasser A., Hein S., Drexler H.C., Arnon E., Hayakawa Y., Zimmermann R., Bauer E., Klovekorn W.P., and Schaper J. Myocytes die by multiple mechanisms in failing human hearts. Circ. Res. 92 (2003) 715-724
61. Knaapen M.W., Davies M.J., De Bie M., Haven A.J., Martinet W., and Kockx M.M. Apoptotic versus autophagic cell death in heart failure. Cardiovasc. Res. 51 (2001) 304-312
62. Kawai K., Qin F., Shite J., Mao W., Fukuoka S., and Liang C.S. Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H1003-H1012
63. Fiordaliso F., Bianchi R., Staszewsky L., Cuccovillo I., Doni M., Laragione T., Salio M., Savino C., Melucci S., Santangelo F., Scanziani E., Masson S., Ghezzi P., and Latini R. Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats. J. Mol. Cell. Cardiol. 37 (2004) 959-968
64. Koitabashi N., Arai M., Tomaru K., Takizawa T., Watanabe A., Niwano K., Yokoyama T., Wuytack F., Periasamy M., Nagai R., and Kurabayashi M. Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca2+-ATPase 2 gene transcription through modification of Sp1 binding. Biochem. Biophys. Res. Commun. 328 (2005) 116-124
65. Palace V.P., Hill M.F., Farahmand F., and Singal P.K. Mobilization of antioxidant vitamin pools and hemodynamic function after myocardial infarction. Circulation 99 (1999) 121-126
66. Singh R.B., Niaz M.A., Rastogi S.S., and Rastogi S. Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian Experiment of Infarct Survival-3). Am. J. Cardiol. 77 (1996) 232-236
67. Fang J.C., Kinlay S., Beltrame J., Hikiti H., and Wainstein M. Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomized trial. Lancet 359 (2002) 1108-1113
68. Salonen R.M., Nyyssonen K., Kaikkonen J., Porkkala-Sarataho E., Voutilainen S., Rissanen T.H., Tuomainen T.P., Valkonen V.P., Ristonmaa U., Lakka H.M., Vanharanta M., Salonen J.T., and Poulsen H.E. Antioxidant Supplementation in Atherosclerosis Prevention Study. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation 107 (2003) 947-953
69. Stephens N.G., Parsons A., Schofield P.M., Kelly F., Cheeseman K., and Mitchinson M.J. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347 (1996) 781-786
70. Jialal I., and Devaraj S. Antioxidants and atherosclerosis: don't throw out the baby with the bath water. Circulation 107 (2003) 926-928
71. Liang C., Rounds N.K., Dong E., Stevens S.Y., Shite J., and Qin F. Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial beta-adrenergic receptor sensitivity in the ferret: normalization by antioxidant vitamins. Circulation 102 (2000) 96-103
72. Butterworth Jr. C.E. Vitamin safety: a current appraisal: 1994 update. Vitam. Nutr. Information Serv. 5 (1995) 1-10