Vitamin C inhibits endothelial cell apoptosis in congestive heart failure

Circulation

Volumn 104, Issue 18, 2001, Pages 2182-2187

  Rössig, Lothar ^a   Hoffmann, Jörg ^a   Hugel, B́ńdicte ^c   Mallat, Ziad ^b   Haase, Astrid ^a   Freyssinet, Jean Marie ^c   Tedgui, Alain ^b   Aicher, Alexandra ^a   Zeiher, Andreas M ^a   Dimmeler, Stefanie ^a  

^a GOETHE UNIVERSITY   (Germany)

^b HÔPITAL LARIBOISIÈRE   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Antioxidants; Apoptosis; Endothelium; Heart failure; Inflammation

Indexed keywords

ANGIOTENSIN; ANTIOXIDANT; ASCORBIC ACID; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CLINICAL ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VITAMIN SUPPLEMENTATION;

EID: 0035975943     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc4301.098284     Document Type: Article

References (29)

1. Endothelium-dependent vasodilation is attenuated in patients with heart failure
2. Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure
3. Mechanisms of exercise intolerance in congestive heart failure
4. Oxygen free radicals and congestive heart failure
5. Increased malondialdehyde in peripheral blood of patients with congestive heart failure
6. Mechanisms and implications of endothelial dysfunction in congestive heart failure
7. Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure
8. Serum from patients with severe heart failure downregulates eNOS and is proapoptotic: Role of tumor necrosis factor-α
9. Congestive heart failure induces endothelial cell apoptosis: Protective role of carvedilol
10. Exposure to low concentrations of hydrogen peroxide causes delayed endothelial cell death and inhibits proliferation of surviving cells
11. 2-induced apoptosis of human endothelial cells by modulation of the glutathione redox cycle and nitric oxide synthase
12. Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors
13. Oxidant signaling in vascular cell growth, death, and survival: A review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling
14. Peripheral vascular endothelial dysfunction and apoptosis in old monkeys
15. Ascorbate is an outstanding antioxidant in human blood plasma
16. The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-I infection
17. Suppression of apoptosis by nitric oxide via inhibition of ICE-like and CPP32-like proteases
18. Cyclosporine A inhibits apoptosis of human endothelial cells by preventing the release of cytochrome C from mitochondria
19. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
20. Evidence of oxidative stress in chronic heart failure in humans
21. Increased oxidative stress in patients with congestive heart failure
22. Neutrophil superoxide anion-generating capacity, endothelial function and oxidative stress in chronic heart failure: Effects of short- and long-term vitamin C therapy
23. Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax
24. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3
25. Mitochondria and apoptosis
26. L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells
27. Dephosphorylation targets Bcl-2 for ubiquitin-degradation: A link between the apoptosome and the proteasome pathway
28. Nitric oxide downregulates MKP-3 mRNA levels: Involvement in endothelial cell protection from apoptosis
29. Apoptosis in the vascular wall and atherosclerosis