Reactive oxygen species contribute to contractile dysfunction following rapid ventricular pacing in dogs*

International Journal of Cardiology

Volumn 83, Issue 2, 2002, Pages 125-131

  Gare, Meir ^a   Mraovic, Boris ^a   Kehl, Franz ^a   Kersten, Judy R ^a   Warltier, David C ^a   Pagel, Paul S ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Myocardial contractility; Myocardial protection; Myocardial stunning; N Acetylcysteine; Rapid ventricular pacing

Indexed keywords

ACETYLCYSTEINE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOG; DOSE RESPONSE; HEART MUSCLE CONTRACTILITY; HEART PACING; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE FUNCTION; HEMODYNAMICS; NONHUMAN; PRIORITY JOURNAL;

ACETYLCYSTEINE; ANALYSIS OF VARIANCE; ANIMALS; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; DOGS; FEMALE; FREE RADICAL SCAVENGERS; HEART FUNCTION TESTS; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL STUNNING; PROBABILITY; RANDOM ALLOCATION; REACTIVE OXYGEN SPECIES; REFERENCE VALUES; STROKE VOLUME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0036253101     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5273(02)00030-X     Document Type: Article

References (34)

1. The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
2. Effects of N-acetylcysteine in the rat heart reperfused after low-flow ischemia: Evidence for a direct scavenging of hydroxyl radicals and a nitric oxide-dependent increase in coronary flow
3. Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment
4. Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin
5. Studies on a sulfhydryl radioprotector of low toxicity
6. N-Acetyl cysteine ameliorates ischemic renal failure
7. N-Acetyl-L-cysteine for preventing lung reperfusion injury after liver ischemia-reperfusion: A possible dual protective mechanism in a dose-response study
8. N-Acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction. Safety and biochemical effects
9. Glutathione redox pathway and reperfusion injury. Effect of N-acetylcysteine on infarct size and ventricular function
10. Oxygen free radicals and myocardial damage: Protective role of thiol-containing agents
11. Myocardial glutathione depletion impairs recovery after short periods of ischemia
12. Relation between myocardial glutathione content and extent of ischemia-reperfusion injury
13. Occurrence of oxidative stress during reperfusion of the human heart
14. Beneficial effects of N-acetylcysteine and cysteine in stunned myocardium in perfused rat heart
15. Cardioprotective effects of N-acetylcysteine: The reduction in the extent of infarction and occurrence of reperfusion arrhythmias in the dog
16. Protective effect of N-acetylcysteine on ischaemia-induced myocardial damage in the canine heart
17. Molecular and cellular mechanisms of myocardial stunning
18. Cumulative deterioration of myocardial function after repeated episodes of exercise-induced ischemia
19. Persistence of regional left ventricular dysfunction after exercise-induced myocardial ischemia
20. Exercise-induced subendocardial dysfunction in dogs with left ventricular hypertrophy
21. Effect of superoxide dismutase and catalase on regional dysfunction after exercise-induced ischemia
22. Pacing-induced ventricular fibrillation leading to oxygen free radical formation in aerobically perfused rat hearts
23. An important role of oxygen free radical on left ventricular function and remodeling in a canine model of tachycardia-induced heart failure
24. ATP channels in dogs
25. Isoflurane causes only minimal increases in coronary blood flow independent of oxygen demand
26. Steal-prone coronary circulation in chronically instrumented dogs: Isoflurane versus adenosine
27. N-Acetylcysteine inhibits muscle fatigue in humans
28. The role of glutathione status in the protection against ischaemic and reperfusion damage: Effects of N-acetylcysteine
29. Total recovery of left ventricular function after acute myocardial infarction: Comprehensive therapy with streptokinase, N-acetylcysteine and percutaneous transluminal coronary angioplasty
30. Fibrinolytic therapy and N-acetylocysteine in the treatment of patients with acute myocardial infarction: Its influence on authentic plasma hydroperoxide levels and polymorphonuclear neutrophil oxygen metabolism
31. Tachycardia-induced cardiomyopathy: A review of animal models and clinical studies
32. Inhibition of in vivo myocardial ischemic and reperfusion injury by a synthetic manganese-based superoxide dismutase mimetic
33. Comparison of the cardiovascular effects of two novel superoxide dismutase mimetics, SC-55858 and SC-54417, in conscious dogs
34. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine