Immunohistochemical examination of phosphorylated tau in granulovacuolar degeneration granules

Psychiatry and Clinical Neurosciences

Volumn 50, Issue 3, 1996, Pages 137-140

  Ikegami, Ken ^a   Kimura, Takemi ^a   Katsuragi, Shoichi ^b   Ono, Tsunehiko ^b   Yamamoto, Hideyuki ^b   Miyamoto, Eishichi ^b   Miyakawa, Taihei ^b  

^a Kikuchi National Hospital Division of Clinical Research   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

granulovacuolar degeneration; neurofibrillary tangle; paired helical filament; phosphorylated tau

Indexed keywords

SERINE; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; ELECTRON MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NEUROFIBRILLARY TANGLE; PROTEIN PHOSPHORYLATION;

EID: 0029974421     PISSN: 13231316     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1819.1996.tb01678.x     Document Type: Article

References (24)

1. Simchowicz T. Histologische Studien uber die senile Demenz. Histologische und histopathologische Arbeiten uber die Grosshirnrinde 1911; 21: 267-444.
2. Price DL, Altschuler RJ, Struble RG, Casanova MF, Cork LC, Murphy DB. Sequestration of tubulin in neurons in Alzheimer's disease. Brain Res. 1986; 385: 305-310.
3. Kahn J, Anderson BH, Probst A, Ulrich J, Esiri MM. Immunohistological study of granulovacuolar degeneration using monoclonal antibodies to neurofilaments. J. Neurol. Neurosug. Psychiatry 1985; 48: 924-926.
4. Gheuens J, Cras P, Perry G et al. Demonstration of a novel neurofilament associated antigen with the neurofibrillary pathology of Alzheimer and related disease. Brain Res. 1991; 558: 43-52.
5. Mena R, Robitaille Y, Cuello C. New patterns of intraneuronal accumulation of the microtubular binding domain of tau in granulovacuolar degeneration. J. Geriatr. Psychiatry Neurol. 1992; 5: 132-141.
6. Dickson DW, Ksiezak-Reding H, Davies P, Yen S-H. A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration. Acta Neuropath. 1987; 73: 254-258.
7. Dickson DW, Ksiezak-Reading K, Liu W-K, Davis P, Crowe A, Yen S-H. Immunohistochemistry of neurofibrillary tangles with antibodies to subregions of tau protein identification of hidden and cleaved tau epitopes and new phosphorylation sites. Acta Neuropathol. 1992; 84: 596-605.
8. Dickson DW, Liu WK, Kres Y, Ku J, DeJeus O, Yen S-H. Phosphorylated tau immunoreactivity of granulovacuolar bodies (GVB) of Alzheimer's disease: Localization of two amino terminal tau epitopes in GVB. Acta Neuropathol. 1993; 85: 463-470.
9. Bondareff W, Wischik CM, Novak M, Roth M. Sequestration of tau by granulovacuolar degenaration in Alzheimer's disease. Am. J. Pathol. 1991; 139: 641-647.
10. Ball MJ. Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients: A quantitative study. Acta Neuropath. 1978; 42: 73-80.
11. Xu M, Shibayama H, Kobayashi H et al. Granulovacuolar degeneration in the hippocampal cortex of aging and demented patients: A quantitative study. Acta Neuropathlol. 1992; 85: 1-9.
12. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders. 3rd edn. revised, APA, Washington DC, 1987.
13. Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch. Neurology 1985; 42: 1097-1105.
14. Ono T, Yamamoto H, Tashima K et al. Dephosphorylation of abnormal sites of tau factor by protein phosphatases and its implication for Alzheimer's disease. Neurochem. Int. 1995; 26: 205-215.
15. Morishima-Kawashima M, Hasegawa M, Takio K et al. Proline-directed and non-proline-directed phosphorylation of PHF-tau. J. Biol. Chem. 1995; 270: 823-829.
16. Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtuble-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 1989; 3: 519-526.
17. Terry RD, Wisnieski H, Johnson AB. Studies on the formation of autophagic vacuoles in neurons treated with spindle inhibitors (colchicine and vinblastine). J. Neuropathol. Exp. Neurol. 1970; 29: 142-143 (abstract).
18. Hirano A, Dembitzer HM, Kurland LT, Zimmerman HM. The fine structure of some intraganglionic alternations. J. Neuropathol. Exp. Neurol. 1968; 27: 167-182.
19. Oyanagi S, Ikuta F. An ultrastructural observation on granulovacuolar degenerations in reference to the process of their formation. Brain and Nerve 1974; 26: 783-788 (in Japanese).
20. Okamoto K, Hirai S, Iizuka T, Yanagisawa T, Watanabe M. Reexamination of granulovacuolar degenaration. Acta Neuro-pathol. 1991; 82: 340-345.
21. Wisnieski HM, Terry RD. Morphology of the aging brain, human and animal. Prog. Brain Res. 1973; 40: 167-186.
22. Shin R-W, Lee VM, Trojanowski JQ. Aluminium modifies the properties of Alzheimer's disease PHF-tau in vivo and in vitro. J. Neurosci. 1994; 14: 7221-7233.
23. Yan S-D, Chen X, Schidt A-M et al. Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress. Proc. Natl Acad. Sci. USA 1994; 91: 7787-7791.
24. Lang E, Otvos L. A serine-proline change in the Alzheimer's disease-associated epitope tau-2 results in altered secondary structure but phosphorylation overcomes the conformational gap. Biochem. Biophys. Res. Commun. 1992; 188: 162-169.