-
1
-
-
0025160288
-
Discodermolide: A new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
-
(correction: 56.1346, 1991)
-
Gunasekera, S.P. et al., Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta, J. Org. Chem., 55, 4912, 1990 (correction: 56.1346, 1991).
-
(1990)
J. Org. Chem.
, vol.55
, pp. 4912
-
-
Gunasekera, S.P.1
-
2
-
-
0025942924
-
Discodermolide: A new marine-derived immunosuppressive compound. I
-
Longley, R.E. et al., Discodermolide: a new marine-derived immunosuppressive compound. I. In vitro studies, Transplantation, 52, 650, 1991.
-
(1991)
Vitro Studies, Transplantation
, vol.52
, pp. 650
-
-
Longley, R.E.1
-
3
-
-
0025936629
-
Discodermolide: A new marine-derived immunosuppressive compound. II
-
Longley, R.E. et al., Discodermolide: a new marine-derived immunosuppressive compound. II. In vivo studies, Transplantation, 52, 656, 1991.
-
(1991)
Vivo Studies, Transplantation
, vol.52
, pp. 656
-
-
Longley, R.E.1
-
4
-
-
0028505014
-
Distinct binding and cellular properties of synthetic (+)-and (-)-discodermolides
-
Hung, D. T., Nerenberg, J.B., and Schreiber, S.L., Distinct binding and cellular properties of synthetic (+)-and (-)-discodermolides, Chem. Biol., 1, 67, 1994.
-
(1994)
Chem. Biol.
, vol.1
, pp. 67
-
-
Hung, D.T.1
Nerenberg, J.B.2
Schreiber, S.L.3
-
5
-
-
0019859353
-
Taxol binding to polymerized tubulin in vitro
-
Parness, J. and Horwitz, S.B., Taxol binding to polymerized tubulin in vitro, J. Cell Biol., 91, 479, 1981.
-
(1981)
J. Cell Biol.
, vol.91
, pp. 479
-
-
Parness, J.1
Horwitz, S.B.2
-
6
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a Taxol-like mechanism of action
-
Bollag, P.A. et al., Epothilones, a new class of microtubule-stabilizing agents with a Taxol-like mechanism of action, Cancer Res., 55, 2325, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 2325
-
-
Bollag, P.A.1
-
7
-
-
0034903353
-
New natural epothilones from Sorangium cellulosum, strains Soce90/B2 and So ce90/D13: Isolation, structure elucidation and SAR studies
-
Hardt, I.H. et al., New natural epothilones from Sorangium cellulosum, strains Soce90/B2 and So ce90/D13: isolation, structure elucidation and SAR studies, J. Nat. Prod., 64, 847, 2001.
-
(2001)
J. Nat. Prod.
, vol.64
, pp. 847
-
-
Hardt, I.H.1
-
8
-
-
0030984058
-
Eleutherobin, a new cytotoxin that mimics Paclitaxel (Taxol) by stabilizing microtubules
-
Lindel, T. et al., Eleutherobin, a new cytotoxin that mimics Paclitaxel (Taxol) by stabilizing microtubules, J. Am. Chem. Soc., 119, 8744, 1997.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 8744
-
-
Lindel, T.1
-
9
-
-
0033083045
-
Laulimalide and isolaulimalide, a new paclitaxel-like microtubule-stabilizing agent
-
Mooberry, S.L. et al., Laulimalide and isolaulimalide, a new paclitaxel-like microtubule-stabilizing agent, Cancer Res., 59, 653, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 653
-
-
Mooberry, S.L.1
-
10
-
-
0038005594
-
Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin, Biochem
-
Isbrucker, R.A. et al., Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin, Biochem. Pharmacol., 66, 75, 2003.
-
(2003)
Pharmacol.
, vol.66
, pp. 75
-
-
Isbrucker, R.A.1
-
11
-
-
0033518052
-
Gram-scale synthesis of (+)-discodermolide
-
Smith, III A.B. et al., Gram-scale synthesis of (+)-discodermolide, Org. Lett., 1, 1823, 1999.
-
(1999)
Org. Lett.
, vol.1
, pp. 1823
-
-
Smith, I.1
-
12
-
-
38149147428
-
Species differentiation in the marine sponge genus Discodermia (Demospongiae: Lithistida): The utility of ethanol extract profiles as species-specific chemotaxonomic markers
-
Kelly-Borges, M. et al., Species differentiation in the marine sponge genus Discodermia (Demospongiae: Lithistida): the utility of ethanol extract profiles as species-specific chemotaxonomic markers, Biochem. Syst. Ecol., 22, 353, 1994.
-
(1994)
Biochem. Syst. Ecol.
, vol.22
, pp. 353
-
-
Kelly-Borges, M.1
-
13
-
-
0001212607
-
Discodermide: A new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta
-
Gunasekera, S.P., Gunasekera, M., and McCarthy, P., Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta, J. Org. Chem., 56, 4830, 1991.
-
(1991)
J. Org. Chem.
, vol.56
, pp. 4830
-
-
Gunasekera, S.P.1
Gunasekera, M.2
McCarthy, P.3
-
14
-
-
0026519660
-
Polydiscamide A: A new bioactive depsipeptide from the marine sponge Discodermia sp
-
Gulavita, N.K. et al., Polydiscamide A: a new bioactive depsipeptide from the marine sponge Discodermia sp., J. Org. Chem., 57, 1767, 1992.
-
(1992)
J. Org. Chem.
, vol.57
, pp. 1767
-
-
Gulavita, N.K.1
-
15
-
-
0036853788
-
Five new discodermolide analogs from the marine sponge Discodermia sp
-
Gunasekera, S.P. et al., Five new discodermolide analogs from the marine sponge Discodermia sp., J. Nat. Prod., 65, 1643, 2002.
-
(2002)
J. Nat. Prod.
, vol.65
, pp. 1643
-
-
Gunasekera, S.P.1
-
16
-
-
0035826325
-
Solution structure of (+)-discodermolide
-
Smith A.B. III, LaMarche, M.J., and Falcone-Hindley, M., Solution structure of (+)-discodermolide, Org. Lett., 3, 695, 2001.
-
(2001)
Org. Lett.
, vol.3
, pp. 695
-
-
Smith, A.1
Lamarche, M.J.2
Falcone-Hindley, M.3
-
17
-
-
0027858856
-
Total synthesis of the immunosuppressive agent (-)-discodermolide
-
Nerenberg, J.B. et al., Total synthesis of the immunosuppressive agent (-)-discodermolide, J. Am. Chem. Soc., 115, 12621, 1993.
-
(1993)
J. Am. Chem. Soc.
, vol.115
-
-
Nerenberg, J.B.1
-
18
-
-
0029860912
-
Synthesis of discodermolides useful for investigating microtubule binding and stabilization
-
Hung, D. T., Nerenberg, J.B., and Schreiber, S.L., Synthesis of discodermolides useful for investigating microtubule binding and stabilization, J. Am. Chem. Soc., 118, 11054, 1996.
-
(1996)
J. Am. Chem. Soc.
, vol.118
-
-
Hung, D.T.1
Nerenberg, J.B.2
Schreiber, S.L.3
-
19
-
-
0029619410
-
Total synthesis of (-)-discodermolide
-
Smith III A.B. et al., Total synthesis of (-)-discodermolide, J. Am. Chem. Soc., 117, 12011, 1995.
-
(2011)
J. Am. Chem. Soc.
, vol.117
, Issue.1
, pp. 1995
-
-
Smith, I.1
-
20
-
-
0030772544
-
Total synthesis of (-)-discodermolide: An application of a chelation-controlled alkylation reaction
-
Harried, S.S. et al., Total synthesis of (-)-discodermolide: an application of a chelation-controlled alkylation reaction, J. Org. Chem., 62, 6098, 1997.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 6098
-
-
Harried, S.S.1
-
21
-
-
0042510054
-
Total synthesis of (+)-discodermolide, a microtubule-stabilizing agent from the sponge Discodermia dissoluta
-
Harried, S.S. et al., Total synthesis of (+)-discodermolide, a microtubule-stabilizing agent from the sponge Discodermia dissoluta, J. Org. Chem., 68, 6646, 2003.
-
(2003)
J. Org. Chem.
, vol.68
, pp. 6646
-
-
Harried, S.S.1
-
22
-
-
0032582745
-
Total synthesis of (+)-discodermolide
-
Marshall, J.A. and Jones, B.A., Total synthesis of (+)-discodermolide, J. Org. Chem., 63, 7885, 1998.
-
(1998)
J. Org. Chem.
, vol.63
, pp. 7885
-
-
Marshall, J.A.1
Jones, B.A.2
-
23
-
-
0035802349
-
A practical synthesis of (+)-discodermolide and analogs: Fragment union by complex aldol reactions
-
Paterson, I. et al., A practical synthesis of (+)-discodermolide and analogs: fragment union by complex aldol reactions, J. Am. Chem. Soc., 123, 9535, 2001.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 9535
-
-
Paterson, I.1
-
24
-
-
0034597447
-
The chemistry and biology of discodermolide
-
Kalesse, M., The chemistry and biology of discodermolide, Chem. BioChem., 1, 171, 2000.
-
(2000)
Chem. Biochem.
, vol.1
, pp. 171
-
-
Kalesse, M.1
-
25
-
-
0034644383
-
Evolution of a gram-scale synthesis of (+)-discodermolide
-
Smith, III A.B. et al., Evolution of a gram-scale synthesis of (+)-discodermolide, J. Am. Chem. Soc., 122, 8654.
-
J. Am. Chem. Soc.
, vol.122
, pp. 8654
-
-
Smith, I.1
-
26
-
-
0842285267
-
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 1: Synthetic strategy and preparation of a common precursor
-
Mickel, S.J. et al., Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 1: synthetic strategy and preparation of a common precursor, Org. Process Res. Dev., 8, 92, 2004.
-
(2004)
Org. Process Res. Dev
, vol.8
, pp. 92
-
-
Mickel, S.J.1
-
27
-
-
0842263632
-
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 2: Synthesis of fragments C1-6 and C9-14
-
Mickel, S. J. et al., Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 2: synthesis of fragments C1-6 and C9-14, Org. Process Res. Dev., 8, 101, 2004.
-
(2004)
Org. Process Res. Dev
, vol.8
, pp. 101
-
-
Mickel, S.J.1
-
28
-
-
0842285266
-
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 3: Synthesis of fragment C15-21
-
Mickel, S.J. et al., Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 3: synthesis of fragment C15-21, Org. Process Res. Dev., 8, 107, 2004.
-
(2004)
Org. Process Res. Dev
, vol.8
, pp. 107
-
-
Mickel, S.J.1
-
29
-
-
0842328441
-
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 4: Preparation of fragment C7-24
-
Mickel, S.J. et al., Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 4: preparation of fragment C7-24, Org. Process Res. Dev., 8, 113, 2004.
-
(2004)
Org. Process Res. Dev
, vol.8
, pp. 113
-
-
Mickel, S.J.1
-
30
-
-
0842306927
-
Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 5: Linkage of fragments C1-6 and C7-24 and finale
-
Mickel, S.J. et al., Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 5: linkage of fragments C1-6 and C7-24 and finale, Org. Process Res. Dev., 8, 122, 2004.
-
(2004)
Org. Process Res. Dev
, vol.8
, pp. 122
-
-
Mickel, S.J.1
-
31
-
-
0034677179
-
Total synthesis of the antimicrotubule agent (+)-discodermolide using boronmediated aldol reactions of chiral ketones
-
Paterson, I. et al., Total synthesis of the antimicrotubule agent (+)-discodermolide using boronmediated aldol reactions of chiral ketones, Angew. Chem. Int. Ed., 39, 377, 2000.
-
(2000)
Angew. Chem. Int. Ed
, vol.39
, pp. 377
-
-
Paterson, I.1
-
32
-
-
0034826406
-
The relationship between Taxol and (+)-discodermolide: Synthetic analogs and modeling studies
-
Martello, L.A. et al., The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies, Chem. Biol., 8, 843, 2001.
-
(2001)
Chem. Biol.
, vol.8
, pp. 843
-
-
Martello, L.A.1
-
33
-
-
0035089418
-
Acetylated analogs of the microtubule-stabilizing agent discodermolide: Preparation and biological activity
-
Gunasekera, S P., Longley, R.E., and Isbrucker, R.A., Acetylated analogs of the microtubule-stabilizing agent discodermolide: preparation and biological activity, J. Nat. Prod., 64, 171, 2001.
-
(2001)
J. Nat. Prod.
, vol.64
, pp. 171
-
-
Gunasekera, S.P.1
Longley, R.E.2
Isbrucker, R.A.3
-
34
-
-
0036932485
-
Semisynthetic analogs of the microtubulestabilizing agent discodermolide: Preparation and biological activity
-
Gunasekera, S.P., Longley, R.E., and Isbrucker, R.A., Semisynthetic analogs of the microtubulestabilizing agent discodermolide: preparation and biological activity, J. Nat. Prod., 65, 1830, 2002.
-
(2002)
J. Nat. Prod.
, vol.65
, pp. 1830
-
-
Gunasekera, S.P.1
Longley, R.E.2
Isbrucker, R.A.3
-
35
-
-
2542520849
-
Synthetic analogs of the microtubule-stabilizing agent (+)-discodermolide: Preparation and biological activity
-
Gunasekera, S.P. et al., Synthetic analogs of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity, J. Nat. Prod., 67, 749, 2004.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 749
-
-
Gunasekera, S.P.1
-
36
-
-
0027744163
-
Immunosuppression by discodermolide
-
Longley, R.E. et al., Immunosuppression by discodermolide, Ann. N. Y. Acad. Sci., 696, 94, 1993.
-
(1993)
Ann. N. Y. Acad. Sci.
, vol.696
, pp. 94
-
-
Longley, R.E.1
-
37
-
-
0001723343
-
Graft versus host reactions: Their natural history and applicability as tools of research
-
Simonsen, M., Graft versus host reactions: their natural history and applicability as tools of research, Prog. Allergy, 6, 349, 1962.
-
(1962)
Prog. Allergy
, vol.6
, pp. 349
-
-
Simonsen, M.1
-
38
-
-
0017157814
-
Biological effects of cyclosporin A: A new antilymphocytic agent
-
Borel, J.F. et al., Biological effects of cyclosporin A: a new antilymphocytic agent, Agent Action, 6, 468, 1977.
-
(1977)
Agent Action
, vol.6
, pp. 468
-
-
Borel, J.F.1
-
39
-
-
84881556839
-
-
U. S. Patent 5,840,750 issued November 24
-
Longley, R.E., Gunasekera, S.P., and Pomponi, S.A., Discodermolide compounds. U. S. Patent 5,840,750 issued November 24, 1998.
-
(1998)
Discodermolide Compounds
-
-
Longley, R.E.1
Gunasekera, S.P.2
Pomponi, S.A.3
-
40
-
-
85055217178
-
The NCI in vitro anticancer drug discovery screen
-
Boyd, M.R., The NCI in vitro anticancer drug discovery screen, Cancer Lett., 15, 6, 1989.
-
(1989)
Cancer Lett
, vol.15
, pp. 6
-
-
Boyd, M.R.1
-
41
-
-
0030039669
-
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
-
ter Harr, E. et al., Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol, Biochemistry, 35, 243, 1996.
-
(1996)
Biochemistry
, vol.35
, pp. 243
-
-
Ter Harr, E.1
-
42
-
-
0030113284
-
(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest
-
Hung, D.T., Chen, J., and Schreiber, S.L., (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest, Chem. Biol., 3, 287, 1996.
-
(1996)
Chem. Biol.
, vol.3
, pp. 287
-
-
Hung, D.T.1
Chen, J.2
Schreiber, S.L.3
-
43
-
-
0027249107
-
A novel model of a metastatic breast tumour xenograft line
-
Hurst, J. et al., A novel model of a metastatic breast tumour xenograft line, Br. J. Cancer, 68, 274, 1993.
-
(1993)
Br. J. Cancer
, vol.68
, pp. 274
-
-
Hurst, J.1
-
44
-
-
12944277104
-
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
-
Giannakakou, P. et al., A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells, Proc. Natl. Acad. Sci. USA, 97, 2904, 2000.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 2904
-
-
Giannakakou, P.1
-
45
-
-
0034636084
-
A common pharmacophore for Taxol® and the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain
-
He, L. et al., A common pharmacophore for Taxol® and the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain, Biochemistry, 39, 3972, 2000.
-
(2000)
Biochemistry
, vol.39
, pp. 3972
-
-
He, L.1
-
46
-
-
85055220869
-
-
Abstract A252 2003, AACRNCI-EORTC Meeting, Molecular Target and Cancer therapeutics, Boston, MA, November 17–21
-
Mita, C. et al., Phase 1 and pharmacokinetic study of XAA296A (discodermolide) administered once every three weeks in adult patients with advanced solid malignancies, Abstract A252 2003, AACRNCI-EORTC Meeting, Molecular Target and Cancer therapeutics, Boston, MA, November 17–21, 2003.
-
(2003)
Phase 1 and Pharmacokinetic Study of XAA296A (Discodermolide) Administered Once Every Three Weeks in Adult Patients with Advanced Solid Malignancies
-
-
Mita, C.1
|