The contribution of biophysical lung injury to the development of biotrauma

Annual Review of Physiology

Volumn 68, Issue , 2006, Pages 585-618

  Dos Santos, Claudia C ^a   Slutsky, Arthur S ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL VENTILATION; BIOPHYSICS; CELL METABOLISM; CRITICAL ILLNESS; DISEASE SEVERITY; GENE EXPRESSION; HUMAN; HYPOXIA; LUNG INJURY; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME; RESPIRATORY FAILURE; RESUSCITATION; REVIEW; SYMPTOMATOLOGY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; BAROTRAUMA; BIOPHYSICS; HUMANS; LUNG; LUNG DISEASES; MULTIPLE ORGAN FAILURE; RESPIRATION, ARTIFICIAL;

EID: 33646003577     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.68.072304.113443     Document Type: Review

References (146)

1. Goss CH, Brower RG, Hudson LD, Rubenfeld GD. 2003. Incidence of acute lung injury in the United States. Crit. Care Med. 31:1607-11
2. Luhr OR, Antonsen K, Karlsson M, Aardal S, Thorsteinsson A, et al. 1999. Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland. The ARF Study Group. Am. J. Respir. Crit. Care Med. 159:1849-61
3. Hudson LD, Steinberg KP. 1999. Epidemiology of acute lung injury and ARDS. Chest 116:748-828
4. Rubenfeld GD, Angus DC, Pinsky MR, Curtis JR, Connors AF Jr, Bernard GR. 1999. Outcomes research in critical care: results of the American Thoracic Society Critical Care Assembly Workshop on Outcomes Research. The Members of the Outcomes Research Workshop. Am. J. Respir. Crit. Care Med. 160:358-67
5. Esteban A, Anzueto A, Alia I, Gordo F, Apezteguia C, et al. 2000. How is mechanical ventilation employed in the intensive care unit? An international utilization review. Am. J. Respir. Crit. Care Med. 161:1450-58
6. Esteban A, Anzueto A, Frutos F, Alia I, Brochard L, et al. 2002. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287:345-55
7. Petty TL, Ashbaugh DG. 1971. The adult respiratory distress syndrome. Clinical features, factors influencing prognosis and principles of management. Chest 60:233-39
8. Brun-Buisson C, Minelli C, Bertolini G, Brazzi L, Pimentel J, et al. 2004. Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study. Intensive Care Med. 30:51-61
9. Rubenfeld GD. 2003. Epidemiology of acute lung injury. Crit. Care Med. 31: S276-S284
10. Bersten AD, Edibam C, Hunt T, Moran J. 2002. Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian states. Am. J. Respir. Crit. Care Med. 165:443-48
11. Abel SJ, Finney SJ, Brett SJ, Keogh BF, Morgan CJ, Evans TW. 1998. Reduced mortality in association with the acute respiratory distress syndrome (ARDS). Thorax 53:292-94
12. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, et al. 1994. The American-European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am. J. Respir. Crit. Care Med. 149:818-24
13. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, et al. 1994. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med. 20:225-32
14. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, et al. 1994. Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. The Consensus Committee. J. Crit. Care 9:72-81
15. Tremblay LN, Slutsky AS. 1998. Ventilator-induced injury: from barotrauma to biotrauma. Proc. Assoc. Am. Physicians 110:482-88
16. Slutsky AS, Tremblay LN. 1998. Multiple system organ failure. Is mechanical ventilation a contributing factor? Am. J. Respir. Crit. Care Med. 157:1721-25
17. Slutsky AS. 1999. Lung injury caused by mechanical ventilation. Chest 116:9S-15S
18. The Acute Respiratory Distress Syndrome Network. 2000. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med. 342:1301-8
19. Sosin VV. 1959. On clinical manifestations of barotrauma of the lungs. Vojnosanit. Pregl. 8:46-48 (In Russian)
20. Denney MK, Glas WW. 1964. Experimental studies in barotrauma. J. Trauma 27:791-96
21. Dreyfuss D, Saumon G. 1998. Ventilator-induced lung injury: lessons from experimental studies. Am. J. Respir. Crit. Care Med. 157:294-323
22. American Thoracic Society. 1999. International consensus conferences in intensive care medicine: Ventilator-associated lung injury in ARDS. Am. J. Respir. Crit. Care Med. 160:2118-24
23. Barth PJ, Holtermann W, Muller B. 1998. The spatial distribution of pulmonary lesions in severe ARDS. An autopsy study of 35 cases. Pathol. Res. Pract. 194:465-71
24. Gattinoni L, Pesenti A, Avalli L, Rossi F, Bombino M. 1987. Pressure-volume curve of total respiratory system in acute respiratory failure. Computed tomographic scan study. Am. Rev. Respir. Dis. 136:730-36
25. Schiller HJ, McCann UG, Carney DE, Gatto LA, Steinberg JM, Nieman GF. 2001. Altered alveolar mechanics in the acutely injured lung. Crit. Care Med. 29:1049-55
26. Mead J, Takishima T, Leith D. 1970. Stress distribution in lungs: a model of pulmonary elasticity. J. Appl. Physiol. 28:596-608
27. Geiser T. 2003. Mechanisms of alveolar epithelial repair in acute lung injury-a translational approach. Swiss. Med. Wkly. 133:586-90
28. Vlahakis NE, Hubmayr RD. 2005. Cellular stress failure in ventilator injured lungs. Am. J. Respir. Crit. Care Med. 171:1328-42
29. Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, et al. 2002. Ventilator-induced lung injury: in vivo and in vitro mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 283:L678-82
30. Mendez JL, Hubmayr RD. 2005. New insights into the pathology of acute respiratory failure. Curr. Opin. Crit. Care 11:29-36
31. Matute-Bello G, Martin TR. 2003. Science review, apoptosis in acute lung injury. Crit. Care 7:355-58
32. Martin TR, Nakamura M, Matute-Bello G. 2003. The role of apoptosis in acute lung injury. Crit. Care Med. 31:S184-88
33. Marini JJ, Hotchkiss JR, Broccard AF. 2003. Bench-to-bedside review: microvascular and airspace linkage in ventilator-induced lung injury. Crit. Care 7:435-44
34. Marini JJ. 2004. Microvasculature in ventilator-induced lung injury: target or cause? Minerva Anestesiol. 70:167-73
35. Pugin J. 2002. Is the ventilator responsible for lung and systemic inflammation? Intensive Care Med. 28:817-19
36. Pugin J. 2003. Molecular mechanisms of lung cell activation induced by cyclic stretch. Crit. Care Med. 31:S200-6
37. Tschumperlin DJ, Oswari J, Margulies AS. 2000. Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude. Am. J. Respir. Crit. Care Med. 162:357-62
38. Nucci G, Suki B, Lutchen K. 2003. Modeling airflow-related shear stress during heterogeneous constriction and mechanical ventilation. J. Appl. Physiol. 95:348-56
39. Liu M, Post M. 2000. Invited review: mechanochemical signal transduction in the fetal lung. J. Appl. Physiol. 89:2078-84
40. Liu M, Tanswell AK, Post M. 1999. Mechanical force-induced signal transduction in lung cells. Am. J. Physiol. 277: L667-83
41. dos Santos CC, Slutsky AS. 2000. Invited review: mechanisms of ventilator-induced lung injury: a perspective. J. Appl. Physiol. 89:1645-55
42. Uhlig S. 2002. Ventilation-induced lung injury and mechanotransduction: stretching it too far? Am. J. Physiol. Lung Cell Mol. Physiol. 282:L892-96
43. +-ATPase activity. J. Appl. Physiol. 87:715-21
44. Waters CM, Chang JY, Glucksberg MR, DePaola N, Grotberg JB. 1997. Mechanical forces alter growth factor release by pleural mesothelial cells. Am. J. Physiol. 272:L552-57
45. Lionetti V, Recchia FA, Ranieri VM. 2005. Overview of ventilator-induced lung injury mechanisms. Curr. Opin. Crit. Care 11:82-86
46. Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, et al. 2005. Visualizing the mechanical activation of Src. Nature 434:1040-45
47. Tschumperlin DJ, Dai G, Maly IV, Kikuchi T, Laiho LH, et al. 2004. Mechanotransduction through growth-factor shedding into the extracellular space. Nature 429:83-86
48. Shikata Y, Rios A, Kawkitinarong K, De-Paola N, Garcia JG, Birukov KG. 2005. Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells. Exp. Cell Res. 304:40-49
49. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. 1997. Injurious ventilatory strategies increase cytokines and c-fos mRNA expression in an isolated rat lung model. J. Clin. Invest. 99:944-52
50. Pugin J, Dunn I, Jolliet P, Tassaux D, Magnenat JL, et al. 1998. Activation of human macrophages by mechanical ventilation in vitro. Am. J. Physiol. 275:L1040-50
51. Vlahakis NE, Schroeder MA, Limper AH, Hubmayr RD. 1999. Stretch induces cytokine release by alveolar epithelial cells in vitro. Am. J. Physiol. 277:L167-73
52. Dunn I, Pugin J. 1999. Mechanical ventilation of various human lung cells in vitro: identification of the macrophage as the main producer of inflammatory mediators. Chest 116:95S-97S
53. Oudin S, Pugin J. 2002. Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch. Am. J. Respir. Cell Mol. Biol. 27:107-14
54. Tremblay LN, Miatto D, Hamid Q, Govindarajan A, Slutsky AS. 2002. Injurious ventilation induces widespread pulmonary epithelial expression of tumor necrosis factor-α, and interleukin-6 messenger RNA. Crit. Care Med. 30:1693-700
55. Ma SF, Grigoryev DN, Taylor AD, Nonas S, Sammani S, et al. 2005. Bioinformatic identification of novel early stress response genes in rodent models of lung injury. Am. J. Physiol Lung Cell Mol. Physiol. 289:L468-77
56. Grigoryev DN, Ma SF, Irizarry RA, Ye SQ, Quackenbush J, Garcia JG. 2004. Orthologous gene-expression profiling in multi-species models: search for candidate genes. Genome Biol. 5:R34
57. Altemeier WA, Matute-Bello G, Gharib SA, Glenny RW, Martin TR, Liles WC. 2005. Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. J. Immunol. 175:3369-76
58. Copland IB, Kavanagh BP, Engelberts D, McKerlie C, Belik J, Post M. 2003. Early changes in lung gene expression due to high tidal volume. Am. J. Respir. Crit. Care Med. 168:1051-59
59. Wilson MR, Choudhury S, Goddard ME, O'Dea KP, Nicholson AG, Takata M, 2003. High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury. J. Appl. Physiol. 95:1385-93
60. von Bethmann AN, Brasch F, Nusing R, Vogt K, Volk HD, et al. 1998. Hyperventilation induces release of cytokines from perfused mouse lung. Am. J. Respir. Crit. Care Med. 157:263-72
61. Choudhury S, Wilson MR, Goddard ME, O'Dea KP, Takata M. 2004. Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 287:L902-10
62. Dreyfuss D, Ricard JD, Saumon G. 2003. On the physiologic and clinical relevance of lung-borne cytokines during ventilator-induced lung injury. Am. J. Respir. Crit. Care Med. 167:1467-71
63. Uhlig S, Ranieri M, Slutsky AS. 2004. Biotrauma hypothesis of ventilator-induced lung injury. Am. J. Respir. Crit. Care Med. 169:314-15
64. Ricard JD, Dreyfuss D, Saumon G. 2001. Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. Am. J. Respir. Crit. Care Med. 163:1176-80
65. Verbrugge SJ, Uhlig S, Neggers SJ, Martin C, Held HD, et al. 1999. Different ventilation strategies affect lung function but do not increase tumor necrosis factor-α and prostacyclin production in lavaged rat lungs in vivo. Anesthesiology 91:1834-43
66. Wrigge H, Uhlig U, Zinserling J, Behrends-Callsen E, Ottersbach G, et al. 2004. The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery. Anesth. Analg. 98:775-81
67. Bregeon F, Delpierre S, Chetaille B, Kajikawa O, Martin TR, et al. 2005. Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia. Anesthesiology 102:331-39
68. Bregeon F, Roch A, Delpierre S, Ghigo E, Autillo-Touati A, et al. 2002. Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription. Respir. Physiol. Neurobiol. 132:191-203
69. Kurahashi K, Ota S, Nakamura K, Nagashima Y, Yazawa T, et al. 2004. Effect of lung-protective ventilation on severe Pseudomonas aeruginosa pneumonia and sepsis in rats. Am. J. Physiol. Lung Cell Mol. Physiol. 287:L402-10
70. Moriyama K, Ishizaka A, Nakamura M, Kubo H, Kotani T, et al. 2004. Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Am. J. Physiol. Lung Cell Mol. Physiol. 286:L1114-21
71. Chiumello D, Pristine G, Slutsky AS. 1999. Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 160:109-16
72. Haitsma JJ, Uhlig S, Goggel R, Verbrugge SJ, Lachmann U, Lachmann B. 2000. Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-α. Intensive Care Med. 26:1515-22
73. Imai Y, Kawano T, Miyasaka K, Takata M, Imai T, Okuyama K. 1994. Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation. Am. J. Respir. Crit. Care Med. 150:1550-54
74. Imai Y, Kawano T, Iwamoto S, Nakagawa S, Takata M, Miyasaka K. 1999. Intra-tracheal anti-tumor necrosis factor-α antibody attenuates ventilator-induced lung injury in rabbits. J. Appl. Physiol. 87:510-15
75. Narimanbekov IO, Rozycki HJ. 1995. Effect of IL-1 blockade on inflammatory manifestations of acute ventilator-induced lung injury in arabbit model. Exp. Lung Res. 21:239-54
76. Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, et al. 1999. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282:54-61
77. Ranieri VM, Giunta F, Suter PM, Slutsky AS. 2000. Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome. JAMA 284:43-44
78. Parsons PE, Matthay MA, Ware LB, Eisner MD. 2005. Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 288:L426-31
79. Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, et al. 2005. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit. Care Med. 33:1-6
80. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. 2002. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am. J. Respir. Crit. Care Med. 165:242-49
81. Stuber F, Wrigge H, Schroeder S, Wetegrove S, Zinserling J, et al. 2002. Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury. Intensive Care Med. 28:834-41
82. Verbrugge SJ, Sorm V, van't Veen A, Mouton JW, Gommers D, Lachmann B. 1998. Lung overinflation without positive end-expiratory pressure promotes bacteremia after experimental Klebsiella pneumoniae inoculation. Intensive Care Med. 24:172-77
83. Nahum A, Hoyt J, Schmitz L, Moody J, Shapiro R, Marini JJ. 1997. Effect of mechanical ventilation strategy on dissemination of intratracheally instilled Escherichia coli in dogs. Crit. Care Med. 25:1733-43
84. Murphy DB, Cregg N, Tremblay L, Engelberts D, Laffey JG, et al. 2000. Adverse ventilatory strategy causes pulmonary-to-systemic translocation of endotoxin. Am. J. Respir. Crit. Care Med. 162:27-33
85. Kotani M, Kotani T, Ishizaka A, Fujishima S, Koh H, et al. 2004. Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung. Crit. Care Med. 32:514-19
86. Li LF, Yu L, Quinn DA. 2004. Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase. Am. J. Respir. Crit. Care Med. 169:518-24
87. Belperio JA, Keane MP, Burdick MD, Londhe V, Xue YY, et al. 2002. Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J. Clin. Invest. 110:1703-16
88. Steinberg JM, Schiller HJ, Halter JM, Gatto LA, Lee HM, et al. 2004. Alveolar instability causes early ventilator-induced lung injury independent of neutrophils. Am. J. Respir. Crit. Care Med. 169:57-63
89. Plotz FB, Vreugdenhil HA, Slutsky AS, Zijlstra J, Heijnen CJ, van Vught H. 2002. Mechanical ventilation alters the immune response in children without lung pathology. Intensive Care Med. 28:486-92
90. Herrera MT, Toledo C, Valladares F, Muros M, Diaz-Flores L, et al. 2003. Positive end-expiratory pressure modulates local and systemic inflammatory responses in a sepsis-induced lung injury model. Intensive Care Med. 29:1345-53
91. Altemeier WA, Matute-Bello G, Frevert CW, Kawata Y, Kajikawa O, et al. 2004. Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin. Am. J. Physiol. Lung Cell Mol. Physiol. 287:L533-42
92. Bregeon FDS, Chetaille B, Kajikawa O, Martin TR, Autillo-Touati A, et al. 2005. Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia. Anesthesiology 102(2):331-39
93. Plotz FB, Slutsky AS, van Vught AJ, Heijnen CJ. 2004. Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med. 30:1865-72
94. Frank JA, Matthay MA. 2003. Science review: mechanisms of ventilator-induced injury. Crit. Care 7:233-41
95. Whitehead T, Slutsky AS. 2002. The pulmonary physician in critical care. 7. Ventilator induced lung injury. Thorax 57:635-42
96. Pinhu L, Whitehead T, Evans T, Griffiths M. 2003. Ventilator-associated lung injury. Lancet 361:332-40
97. Reynolds SD, Giangreco A, Hong KU, McGrath KE, Ortiz LA, Stripp BR. 2004. Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction. Am. J. Physiol. Lung Cell Mol. Physiol. 287:L1256-65
98. Vlahakis NE, Hubmayr RD. 2003. Response of alveolar cells to mechanical stress. Curr. Opin. Crit. Care 9:2-8
99. Vlahakis NE, Hubmayr RD. 2000. Invited review: plasma membrane stress failure in alveolar epithelial cells. J. Appl. Physiol. 89:2490-96
100. Wirtz HR, Dobbs LG. 2000. The effects of mechanical forces on lung functions. Respir. Physiol. 119:1-17
101. Mendez JL, Rickman OB, Hubmayr RD. 2004. Plasma membrane stress failure in ventilator-injured lungs. A hypothesis about osmoregulation and the pharmacologic protection of the lungs against deformation injury. Biol. Neonate 85:290-92
102. John E, McDevitt M, Wilborn W, Cassady G. 1982. Ultrastructure of the lung after ventilation. Br. J. Exp. Pathol. 63:401-7
103. Dreyfuss D, Soler P, Saumon G. 1995. Mechanical ventilation-induced pulmonary edema. Interaction with previous lung alterations. Am. J. Respir. Crit. Care Med. 151:1568-75
104. Neal CR, Michel CC. 1997. Transcellular openings through frog microvascular endothelium. Exp. Physiol. 82:419-22
105. Michel CC, Neal CR. 1999. Openings through endothelial cells associated with increased microvascular permeability. Microcirculation 6:45-54
106. Feng D, Nagy JA, Hipp J, Pyne K, Dvorak HF, Dvorak AM. 1997. Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea-pig, mouse and rat: many are transcellular pores. J. Physiol. 504(Pt. 3):747-61
107. Elliott AR, Fu Z, Tsukimoto K, Prediletto R, Mathieu-Costello O, West JB. 1992. Short-term reversibility of ultrastructural changes in pulmonary capillaries caused by stress failure. J. Appl. Physiol. 73:1150-58
108. Birukov KG, Birukova AA, Dudek SM, Verin AD, Crow MT, et al. 2002. Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. Am. J. Respir. Cell Mol. Biol. 26:453-64
109. Parker JC, Hernandez LA, Peevy KJ. 1993. Mechanisms of ventilator-induced lung injury. Crit. Care Med. 21:131-43
110. Dreyfuss D, Basset G, Soler P, Saumon G. 1985. Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am. Rev. Respir. Dis. 132:880-84
111. Webb HH, Tierney DF. 1974. Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure. Am. Rev. Respir. Dis. 110:556-65
112. Broccard A, Shapiro RS, Schmitz LL, Adams AB, Nahum A, Marini JJ. 2000. Prone positioning attenuates and redistributes ventilator-induced lung injury in dogs. Crit. Care Med. 28:295-303
113. Fu Z, Costello ML, Tsukimoto K, Prediletto R, Elliott AR, et al. 1992. High lung volume increases stress failure in pulmonary capillaries. J. Appl. Physiol. 73:123-33
114. Costello ML, Mathieu-Costello O, West JB. 1992. Stress failure of alveolar epithelial cells studied by scanning electron microscopy. Am. Rev. Respir. Dis. 145:1446-55
115. Parker JC, Townsley MI. 2004. Evaluation of lung injury in rats and mice. Am. J. Physiol. Lung Cell Mol. Physiol. 286:L231-46
116. Cakar N, Akinci O, Tugrul S, Ozcan PE, Esen F, et al. 2002. Recruitment maneuver: does it promote bacterial translocation? Crit. Care Med. 30:2103-6
117. Savel RH, Yao EC, Gropper MA. 2001. Protective effects of low tidal volume ventilation in a rabbit model of Pseudomonas aeraginosa-induced acute lung injury. Crit. Care Med. 29:392-98
118. Douzinas EE, Tsidemiadou PD, Pitaridis MT, Andrianakis I, Bobota-Chloraki A, et al. 1997. The regional production of cytokines and lactate in sepsis-related multiple organ failure. Am. J. Respir. Crit. Care Med. 155:53-59
119. Eisner MD, Parsons P, Matthay MA, Ware L, Greene K. 2003. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax 58:983-88
120. Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA. 2003. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit. Care Med. 31:20-27
121. De Pasquale CG, Arnolda LF, Doyle IR, Grant RL, Aylward PE, Bersten AD. 2003. Prolonged alveolocapillary barrier damage after acute cardiogenic pulmonary edema. Crit. Care Med. 31:1060-67
122. De Pasquale CG, Arnolda LF, Doyle IR, Aylward PE, Chew DP, Bersten AD. 2004. Plasma surfactant protein-B: a novel biomarker in chronic heart failure. Circulation 110:1091-96
123. Kendall M, Brown L, Trought K. 2004. Molecular adsorption at particle surfaces: a PM toxicity mediation mechanism. Inhal. Toxicol 16(Suppl. 1):99-105
124. De Pasquale CG, Bersten AD, Doyle IR, Aylward PE, Arnolda LF. 2003. Infarct-induced chronic heart failure increases bidirectional protein movement across the alveolocapillary barrier. Am. J. Physiol. Heart Circ. Physiol. 284:H2136-45
125. Greene R. 1999. Acute lobar collapse: adults and infants differ in important ways. Crit. Care Med. 27:1677-79
126. Doyle IR, Nicholas TE, Bersten AD. 1995. Serum surfactant protein-A levels in patients with acute cardiogenic pulmonary edema and adult respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 152:307-17
127. Doyle IR, Bersten AD, Nicholas TE. 1997. Surfactant proteins-A and -B are elevated in plasma of patients with acute respiratory failure. Am. J. Respir. Crit Care Med. 156:1217-29
128. Pan T, Nielsen LD, Allen MJ, Shannon KM, Shannon JM, et al. 2002. Serum SP-D is a marker of lung injury in rats. Am. J. Physiol. Lung Cell Mol. Physiol. 282:L824-32
129. Guery BP, Welsh DA, Viget NB, Robriquet L, Fialdes P, et al. 2003. Ventilation-induced lung injury is associated with an increase in gut permeability. Shock 19:559-63
130. Edwards YS. 2001. Stretch stimulation: its effects on alveolar type II cell function in the lung. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 129:245-60
131. Del RV, van Tuyl M, Post M. 2004. Apoptosis in lung development and neonatal lung injury. Pediatr. Res. 55:183-89
132. Bardales RH, Xie SS, Schaefer RF, Hsu SM. 1996. Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury. Am. J. Pathol. 149:845-52
133. Matute-Bello G, Liles WC, Steinberg KP, Kiener PA, Mongovin S, et al. 1999. Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS). J. Immunol. 163:2217-25
134. Matute-Bello G, Winn RK, Jonas M, Chi EY, Martin TR, Liles WC. 2001. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am. J. Pathol. 158:153-61
135. Wen LP, Madani K, Fahrni JA, Duncan SR, Rosen GD. 1997. Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas. Am. J. Physiol. 273:L921-29
136. Fine A, Anderson NL, Rothstein TL, Williams MC, Gochuico BR. 1997. Fas expression in pulmonary alveolar type II cells. Am. J. Physiol 213:L64-71
137. Kitamura Y, Hashimoto S, Mizuta N, Kobayashi A, Kooguchi K, et al. 2001. Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice. Am. J. Respir. Crit. Care Med. 163:762-69
138. Matute-Bello G, Liles WC, Frevert CW, Nakamura M, Ballman K, et al. 2001. Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits. Am. J. Physiol. Lung Cell Mol. Physiol. 281:L328-35
139. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, et al. 1999. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit. Care Med. 27:1230-51
140. Hotchkiss RS, Schmieg RE Jr, Swanson PE, Freeman BD, Tinsley KW, et al. 2000. Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock. Crit. Care Med. 28:3207-17
141. Imai Y, de Parodo J, Kajikawa O, Perrot M, Fischer S, et al. 2003. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 289:2104-12
142. Carney D, DiRocco J, Nieman G. 2005. Dynamic alveolar mechanics and ventilator-induced lung injury. Crit. Care Med. 33:S122-28
143. Ye SQ, Simon BA, Maloney JP, Zambelli-Weiner A, Gao L, et al. 2005. Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am. J. Respir. Crit. Care Med. 171:361-70
144. Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, et al. 2002. Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 166:646-50
145. Nesslein LL, Melton KR, Ikegami M, Na CL, Wert SE, et al. 2005. Partial sp-b deficiency perturbs lung function and causes airspace abnormalities. Am. J. Physiol. Lung Cell Mol. Physiol. 288(6):L1154-61
146. McVerry BJ, Peng X, Hassoun PM, Sammani S, Simon BA, Garcia JG. 2004. Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. Am. J. Respir. Crit. Care Med. 170:987-93