-
1
-
-
0038404760
-
Targeting ICAM-l/LFA-l interaction for controlling autoimmune diseases: Designing peptide and small molecule inhibitors
-
Anderson. M.E. and Siahaan. T.J. (2003). Targeting ICAM-l/LFA-l interaction for controlling autoimmune diseases:designing peptide and small molecule inhibitors. Peptides24, 487–501
-
(2003)
Peptides24
, pp. 487-501
-
-
-
2
-
-
14244265717
-
Induced fit of an epitope peptide to a monoclonal antibody probed with a novel parallel surface plasmon resonance assay
-
Baggio, R., Carven. G.J., Chiulli, A., Palmer. M., Stern. L.J. and Arenas, J.E. (2005). Induced fit of an epitope peptide to a monoclonal antibody probed with a novel parallel surface plasmon resonance assay. Journal of Biological Chemistry280(6). 4188–4194
-
(2005)
Journal of Biological Chemistry280(6)
, pp. 4188-4194
-
-
Baggio, R.1
-
3
-
-
0242363259
-
Quest for the best
-
Booth. B. and Zemmel. R. (2003). Quest for the best. Nature Reviews in Drug Discovery2, 838–841
-
(2003)
Nature Reviews in Drug Discovery2
, pp. 838-841
-
-
-
4
-
-
18544399201
-
Clinical studies of reversal of drug resistance based on glutathione. Chemical Biological Interactions 111–112
-
Calvert. P., Yao. K.S., Hamilton. T.C. and O’Dwyer, P.J. (1998). Clinical studies of reversal of drug resistance based on glutathione. Chemical Biological Interactions 111–112, 213–224
-
(1998)
213–224
-
-
-
5
-
-
0034700103
-
A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)
-
Chan. T.F., Carvalho. J., Riles. L. and Zheng. X.F. (2000). A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR). Proceedings of the National Academy of Sciences of the United States of America97, 13227–13232
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America97
, pp. 13227-13232
-
-
-
6
-
-
0242432396
-
Developing a strategy for activity-based detection of enzymes in a protein microarray
-
Chen. G.Y., Uttamchandani. M., Zhu. Q., Wang. G. and Yao. S.Q. (2003). Developing a strategy for activity-based detection of enzymes in a protein microarray. Chembiochemistry4, 336–339
-
(2003)
Chembiochemistry4
, pp. 336-339
-
-
-
7
-
-
5644254327
-
Drug safety. Withdrawal of Vioxx casts a shadow over COX-2 inhibitors
-
Couzin, J. (2004). Drug safety. Withdrawal of Vioxx casts a shadow over COX-2 inhibitors. Science306, 384–385
-
(2004)
Science306
, pp. 384-385
-
-
Couzin, J.1
-
8
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies. S.P., Reddv, H., Caivano. M. and Cohen. P. (2000). Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemical Journal351, 95–105
-
(2000)
Biochemical Journal351
, pp. 95-105
-
-
-
11
-
-
0034651008
-
UPA. a universal protein array system for quantitative detection of protein-protein. protein-DNA. protein-RNA, and protein-ligand interactions
-
Ge. H. (2000). UPA. a universal protein array system for quantitative detection of protein-protein. protein-DNA. protein-RNA, and protein-ligand interactions. Nucleic Acids Research28, e3.
-
(2000)
Nucleic Acids Research28
, vol.e3
-
-
-
12
-
-
5644229499
-
Regulation of gene expression by a metabolic enzyme
-
Hall, D., A., Zhu. H., Zhu. X., Royce. T., Gerstein. M. and Snyder. M. (2004). Regulation of gene expression by a metabolic enzyme. Science306, 482–484
-
(2004)
Science306
, pp. 482-484
-
-
Hall, D.1
-
14
-
-
9344247454
-
Finding new components of the target of rapamycin (TOR) signalling network through chemical genetics and proteome chips
-
Huang, J., Zhu, H., Haggarty, S.J. et al. (2004). Finding new components of the target of rapamycin (TOR) signalling network through chemical genetics and proteome chips. Proceedings of the National Academy of Sciences of the United States of America101, 16594–16599.
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America101
, pp. 16594-16599
-
-
Huang, J.1
Zhu, H.2
Haggarty, S.J.3
-
15
-
-
7244245762
-
Finishing the euchromatic sequence of the human genome
-
International Human Genome Sequencing Consortium (2004). Finishing the euchromatic sequence of the human genome. Nature431, 931–945
-
(2004)
Nature431
, pp. 931-945
-
-
-
16
-
-
1942520229
-
A functional protein chip for pathway optimization and in vitro metabolic engineering
-
Jung, G.Y. and Stephanopoulos, G. (2004). A functional protein chip for pathway optimization and in vitro metabolic engineering. Science304, 428–431
-
(2004)
Science304
, pp. 428-431
-
-
Jung, G.Y.1
Stephanopoulos, G.2
-
17
-
-
0035491482
-
Proteomic profiling of the cancer microenvironment by antibody arrays
-
Knezevic, V., Leethanakul, C., Bichsel, V.E. et al. (2001). Proteomic profiling of the cancer microenvironment by antibody arrays. Proteomics1, 1271–1278
-
(2001)
Proteomics1
, pp. 1271-1278
-
-
Knezevic, V.1
Leethanakul, C.2
Bichsel, V.E.3
-
18
-
-
0043069489
-
Drag research: Myths, hype and reality
-
Kubinyi. H. (2003). Drag research:myths, hype and reality. Nature Reviews in Drug Discovery2, 665–668
-
(2003)
Nature Reviews in Drug Discovery2
, pp. 665-668
-
-
-
19
-
-
0034711209
-
Tyrosine phosphorylation of cortactin is required for H202-mediated injury of human endothelial cells
-
Li. Y., Liu. J. and Zhan, X. (2000). Tyrosine phosphorylation of cortactin is required for H202-mediated injury of human endothelial cells. Journal of Biological Chemistiy275, 37187–37193.
-
(2000)
Journal of Biological Chemistiy275
, pp. 37187-37193
-
-
-
20
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski. C.A., Lombardo, F., Dominy. B.W. and Feeney. P.J. (2001). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews46, 3–26
-
(2001)
Advanced Drug Delivery Reviews46
, pp. 3-26
-
-
-
21
-
-
0034622925
-
Printing proteins as microarrays for high-throughput function determination
-
MacBeath. G. and Schreiber. S.L. (2000). Printing proteins as microarrays for high-throughput function determination. Science289, 1760–1763.
-
(2000)
Science289
, pp. 1760-1763
-
-
-
22
-
-
2542570187
-
Cyclooxygenase-2 inhibitors versus non-selective, non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: A population-based cohort study
-
Mamdani, M., Juurlink, D.N., Lee, D.S. et al. (2004). Cyclooxygenase-2 inhibitors versus non-selective, non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients:a population-based cohort study. Lancet363, 1751–1756
-
(2004)
Lancet363
, pp. 1751-1756
-
-
Mamdani, M.1
Juurlink, D.N.2
Lee, D.S.3
-
23
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning. G., Whyte, D.B., Martinez. R., Hunter. T. and Sudarsanam. S. (2002). The protein kinase complement of the human genome. Science298, 1912–1934
-
(2002)
Science298
, pp. 1912-1934
-
-
-
24
-
-
0036834178
-
Expression of drug resistance gene products during progression of lung carcinomas
-
Mattern, I., Koomagi.R. and Volm.M. (2002). Expression of drug resistance gene products during progression of lung carcinomas. Oncology Reproduction9, 1181–1184.
-
(2002)
Oncology Reproduction9
, pp. 1181-1184
-
-
-
25
-
-
0346753808
-
Analysing antibody specificity with whole proteome microarrays
-
Michaud, G.A., Salcius, M., Zhou, F. et al. (2003). Analysing antibody specificity with whole proteome microarrays. Nature Biotechnology21, 1509–1512
-
(2003)
Nature Biotechnology21
, pp. 1509-1512
-
-
Michaud, G.A.1
Salcius, M.2
Zhou, F.3
-
27
-
-
0037595546
-
Comprehensive identification of human bZIP interactions with coiled-coil arrays
-
Newman, J.R. and Keating, A.E. (2003). Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science300, 2097–2101
-
(2003)
Science300
, pp. 2097-2101
-
-
Newman, J.R.1
Keating, A.E.2
-
28
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design from structure
-
Noble. M.E., Endicott. J.A. and Johnson, L.N. (2004). Protein kinase inhibitors:insights into drug design from structure. Science303, 1800–1805.
-
(2004)
Science303
, pp. 1800-1805
-
-
-
29
-
-
9144252038
-
Complete sequencing and characterization of 21 243 full-length human cDNAs
-
Ota, T., Suzuki, Y., Nishikawa, T. et al. (2004). Complete sequencing and characterization of 21 243 full-length human cDNAs. Nature Genetics36, 40–45
-
(2004)
Nature Genetics36
, pp. 40-45
-
-
Ota, T.1
Suzuki, Y.2
Nishikawa, T.3
-
30
-
-
1042298833
-
Functional protein microarrays: Ripe for discovery
-
Predki. P.F. (2004). Functional protein microarrays:ripe for discovery. Current Opinion in Chemistry and Biology8, 8–13
-
(2004)
Current Opinion in Chemistry and Biology8
, pp. 8-13
-
-
-
31
-
-
0038004738
-
Making better drugs: Decision gates in non-clinical drug development
-
Pritchard, J.F., Jurima-Romet, M., Reimer, M.L., Mortimer, E., Rolfe, B. And Cayen, M.N. (2003). Making better drugs:decision gates in non-clinical drug development. Nature Reviews in Drug Discovery2, 542–553
-
(2003)
Nature Reviews in Drug Discovery2
, pp. 542-553
-
-
Pritchard, J.F.1
Jurima-Romet, M.2
Reimer, M.L.3
Mortimer, E.4
Rolfe, B.A.C.5
-
32
-
-
0242407063
-
Microarrays to characterize protein interactions on a whole-protcome scale
-
Schweitzer. B., Predki. P. and Snyder. M. (2003). Microarrays to characterize protein interactions on a whole-protcome scale. Proteomics3, 2190–2199
-
(2003)
Proteomics3
, pp. 2190-2199
-
-
-
33
-
-
1842431419
-
High-throughput structural biology in drug discovery: Protein kinases
-
Stout. T.J., Foster, P.G. and Matthews. D.J. (2004). High-throughput structural biology in drug discovery:protein kinases. Current Pharmaceutical Design10, 1069–1082
-
(2004)
Current Pharmaceutical Design10
, pp. 1069-1082
-
-
-
34
-
-
0023552288
-
-
Takahashi I., Kobayashi.E., Asano, K., Yoshida, M. and Nakano, H. (I987). UCN-Oi, a selective inhibitor of protein kinase C from Streptomyces. Journal of Antibiotics (Tokyo)40, 1782–1784
-
Takahashi I., Kobayashi.E., Asano, K., Yoshida, M. and Nakano, H. (I987). UCN-Oi, a selective inhibitor of protein kinase C from Streptomyces. Journal of Antibiotics (Tokyo)40, 1782–1784
-
-
-
-
35
-
-
0037364162
-
ADMET in silico modelling: Towards prediction paradise?
-
Van DE Waterbeemd. H. and Gifford, E. (2003). ADMET in silico modelling:towards prediction paradise? Nature Reviews in Drug Discovery2, 192–204
-
(2003)
Nature Reviews in Drug Discovery2
, pp. 192-204
-
-
Van, D.W.H.1
Gifford, E.2
-
36
-
-
0037394124
-
Designing screens: How to make your hits a hit
-
Walters. W.P, and Namchuk, M. (2003). Designing screens:how to make your hits a hit. Nature Reviews in Drug Discovery2, 259–266
-
(2003)
Nature Reviews in Drug Discovery2
, pp. 259-266
-
-
-
37
-
-
0034449920
-
Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammalion
-
Weinberg, J.B. (2000). Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammalion. Immunologic Research22, 319–341
-
(2000)
Immunologic Research22
, pp. 319-341
-
-
Weinberg, J.B.1
-
38
-
-
3042592410
-
The use of in vitro peptide-Iibrary screens in the analysis of phosphoserine/threonine-binding domain structure and function
-
Yaffe, M.B. and Smerdon, S.J. (2004). The use of in vitro peptide-Iibrary screens in the analysis of phosphoserine/threonine-binding domain structure and function. Annual Review of Biophysics and Biomolecular Structure33, 225–244
-
(2004)
Annual Review of Biophysics and Biomolecular Structure33
, pp. 225-244
-
-
Yaffe, M.B.1
Smerdon, S.J.2
-
40
-
-
0035860499
-
Global analysis of protein activities using proteome chips
-
Zhu, H., Bilgin, M., Bangham, R. et al, (2001). Global analysis of protein activities using proteome chips. Science293, 2101–2105.
-
(2001)
Science293
, pp. 2101-2105
-
-
Zhu, H.1
Bilgin, M.2
Bangham, R.3
|