Expression of drug resistance gene products during progression of lung carcinomas

Oncology Reports

Volumn 9, Issue 6, 2002, Pages 1181-1184

  Mattern, Jürgen ^a   Koomägi, Reet ^a   Volm, Manfred ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Drug resistance; Lung cancer; Tumor progression

Indexed keywords

ANTINEOPLASTIC AGENT; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; GLYCOPROTEIN P; GSTP1 PROTEIN, HUMAN; ISOENZYME; METALLOTHIONEIN;

ARTICLE; CANCER STAGING; DISEASE COURSE; DRUG RESISTANCE; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; HUMAN; LUNG NON SMALL CELL CANCER; LUNG TUMOR; METABOLISM; MULTIDRUG RESISTANCE; PROGNOSIS;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE PROGRESSION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOENZYME TECHNIQUES; ISOENZYMES; LUNG NEOPLASMS; METALLOTHIONEIN; NEOPLASM STAGING; P-GLYCOPROTEIN; PROGNOSIS;

EID: 0036834178     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.9.6.1181     Document Type: Article

References (18)

1. Richardson GE and Johnson BE: The biology of lung cancer. Semin Oncol 20: 105-127, 1993. (Pubitemid 23119086)
2. World Health Organization: Histological typing of lung tumours. Tumori 6: 253-272, 1981.
3. Volm M, Mattern J and Samsel B: Overexpression of P-glycoprotein and glutathione S-transferase-π in resistant non-small cell lung carcinomas of smokers. Br J Cancer 64: 700-704, 1991.
4. Volm M, Mattern J, Stammler G, Royer-Pokora B, Schneider S, Weirich A and Ludwig R: Expression of resistance-related proteins in nephroblastoma after chemotherapy. Int J Cancer 63: 193-197, 1995.
5. Goodman LA and Kruskal WH: Measures of association for cross classifications. J Am Stat Assoc 49: 732-764, 1954.
6. Awasthi YC, Singh SV, Ahmad H and Moller PC: Immunohistochemical evidence for the expression of GST1, GST2, and GST3 gene loci for glutathione S-transferase in human lung. Lung 165: 323-332, 1987. (Pubitemid 17165343)
7. Anttila S, Hirvonen A, Vainio H, Husgafvel-Pursiainen K, Hayes JD and Ketterer B: Immunohistochemical localization of glutathione S-transferases in human lung. Cancer Res 53: 5643-5648, 1993. (Pubitemid 23360265)
8. Di Ilio C, Del Boccio G, Aceto A, Casaccia R, Mucilli F and Federici G: Elevation of glutathione transferase activity in human lung tumor. Carcinogenesis 9: 335-340, 1988. (Pubitemid 18038003)
9. Nakagawa K, Saijo N, Tsuchidas S, Sakai M, Tsunokawa Y, Yokota J, Muramatsu M, Sato K, Tereda M and Tew KD: Glutathione S-transferase-π as a detrminant of drug resistance in transfected cell lines. J Biol Chem 265: 4296-4301, 1990.
10. Whelan RDH, Hosking LK, Townsend AJ, Cowan KH and Hill BT: Differential increases in glutathione S-transferase activities in a range of multidrug-resistant human tumor cell lines. Cancer Commun 1: 359-365, 1989.
11. Gros P, Neriah YB, Croop JM and Housman DE: Isolation and expression of a complementary DANN that confers multidrug resistance. Nature 323: 728-731, 1986. (Pubitemid 17172974)
12. Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM and Pastan I: Expression of multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sei USA 84: 265-269, 1987. (Pubitemid 17013615)
13. 6-alkylguanine-DNA alkyltransferase and P-glycoprotein as indicators of drug resistance in tumor and normal lung of patients with lung cancer. Int J Cancer 59: 629-636, 1994.
14. Abe Y, Nakamura M, Ota E, Ozeki Y, Tamai S, Inoue H, Ueyama Y, Ogata T and Tamaoki N: Expression of the multidrug resistance gene (MDR1) in non-small cell lung cancer. Jpn J Cancer Res 85: 536-541, 1994. (Pubitemid 24164643)
15. Hart BA, Voll GW and Vacek PM: Metallothionein in human lung carcinoma. Cancer Lett 75: 121-128, 1993. (Pubitemid 24014535)
16. Hamer DH: Metallothionein. Annu Rev Biochem 55: 913-951, 1986.
17. Kasahara K, Fujiwara Y, Nishio K, Ohmori T, Sugimoto Y, Komiya K, Matsuda T and Saijo N: Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin. Cancer Res 51: 3237-3242, 1991.
18. Kelley SL, Basu A, Teicher BA, Hacker MP, Hamer DH and Lazo JS: Overexpression of metallothionein confers resistance to anticancer drugs. Science 241: 1813-1815, 1988.