The high affinity melatonin binding site probed with conformationally restricted ligands - I. Pharmacophore and minireceptor models

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 8, 1996, Pages 1321-1332

  Jansen, Johanna M ^a,c   Copinga, Swier ^a   Gruppen, Gert ^a   Molinari, Eduardo J ^b   Dubocovich, Margarita L ^b   Grol, Cor J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b NORTHWESTERN UNIVERSITY   (United States)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Melatonin; Minireceptor; Modeling; Pharmacophore; Receptor

Indexed keywords

MELATONIN; MELATONIN RECEPTOR; RECEPTOR SUBTYPE; CELL RECEPTOR; CELL SURFACE RECEPTOR; DRUG DERIVATIVE;

ARTICLE; BINDING SITE; BRAIN; CHICKEN; COMPUTER SIMULATION; DRUG DESIGN; DRUG RECEPTOR BINDING; ENANTIOMER; HAMSTER; LIGAND BINDING; MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RETINA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; COMPUTER PROGRAM; METABOLISM; PROTEIN CONFORMATION; STEREOISOMERISM;

BOS GRUNNIENS; CRICETINAE; GALLUS GALLUS;

ANIMALS; BINDING SITES; CRICETINAE; MELATONIN; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, MELATONIN; SOFTWARE; STEREOISOMERISM;

EID: 0030201178     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00113-7     Document Type: Article

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