Growth hormone secretagogues

Combinatorial Chemistry and High Throughput Screening

Volumn 9, Issue 3, 2006, Pages 175-180

  Isidro, Maria Luisa ^a   Cordido, Fernando ^a,b  

^a HOSPITAL JUAN CANALEJO   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

Ghrelin; Growth hormone; Growth hormone releasing peptides; Growth hormone secretagogues

Indexed keywords

1 [2 (2 AMINO 2 METHYLPROPIONYLAMINO) 3 (1H INDOL 3 YL)PROPIONYL] 3 BENZYL 3 PIPERIDINECARBOXYLIC ACID ETHYL ESTER; 2 AMINO 2 METHYL N [2,3,4,5 TETRAHYDRO 1 [[2' [[[(METHYLAMINO)CARBONYL]AMINO]METHYL][1,1' BIPHENYL] 4 YL]METHYL] 2 OXO 1H BENZAZEPIN 3 YL]PROPIONAMIDE; 3 AMINO 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; EP 01572; EP 51389; GHRELIN; GROWTH HORMONE SECRETAGOGUE; HEXARELIN; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; HUMAN GROWTH HORMONE; HYPOPHYSIS HORMONE; IBUTAMOREN; IPAMORELIN; PEPTIDE DERIVATIVE; PIPERIDINE DERIVATIVE; PRALMORELIN; QUINAZOLINE DERIVATIVE; SM 130686; TABIMORELIN; TRIPEPTIDE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; BIOLOGICAL ACTIVITY; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; FRACTURE; GROWTH DISORDER; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HEART FAILURE; HORMONE ACTION; HORMONE RELEASE; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; GROWTH HORMONE; HUMANS; PEPTIDE HORMONES;

EID: 33645861368     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620706776055458     Document Type: Review

References (37)

1. Ghigo, E.; Arvat, E.; Giordano, R.; Broglio, F.; Gianotti, L.; Maccario, M.; Bisi, G.; Graziani, A.; Papotti, M.; Muccioli, G.; Deghenghi, R.; Camanni, F. Endocrine, 2001, 14, 87.
2. Bowers, C.Y.; Chang, J.; Momany, F.A.; Folkers, K. Molecular Endocrinology, MacIntyre G, Szelke H: Amsterdam, 1977.
3. Casanueva, F.F.; Dieguez, C. Trends Endocrinol. Metab., 1999, 10, 30.
4. Howard, A.D.; Feighner, S.D.; Cully, D.F.; Arena, J.P.; Liberator, P.A.; Rosenblum, C.I.; Hamelin, M.; Hreniuk, D.L.; Palyha, O.C.; Anderson, J.; Paress, P.S.; Diaz, C.; Chou, M.; Liu, K.K.; McKee, K.K.; Pong, S.S.; Chaung, L.Y.; Elbrecht, A.; Dashkevicz, M.; Heavens, R.; Rigby, M.; Sirinathsinghji, D.J.; Dean, D.C.; Melillo, D.G.; Van der Ploeg, L.H. Science, 1996, 273, 974.
5. Kojima, M.; Hosoda, H.; Date, Y.; Nakazato, M.; Matsuo, H.; Kangawa, K. Nature, 1999, 402, 656.
6. van der Lely, A.; Tschöp, M.; Heiman, M.; Ghigo, E. Endocr. Rew., 2004, 25, 426.
7. Broglio, F.; Benso, A.; Gottero, C.; Prodam, F.; Gauna, C.; Filtri, L.; Arvat, E.; van der Lely, A.J.; Deghenghi, R.; Ghigo, E. J. Endocrinol. Invest., 2003, 26, 192.
8. Alvarez, P; Isidro, L; Garcia-Buela, J; Leal-Cerro, A; Broglio, F; Tassone, F; Ghigo, E; Dieguez, C; Casanueva, F; Cordido, F. Clin. Endocrinol., 2004, 61, 255.
9. Baldelli, R.; Otero, X.L.; Camina, J.P.; Gualillo, O.; Popovic, V.; Dieguez, C.; Casanueva, F.F. Endocrine, 2001, 14, 95.
10. Cordido, F; Alvarez-Castro, P; Isidro, L; Casanueva, F; Dieguez, C. Eur. J. Endocrinol., 2003, 149, 122.
11. Peinó, R; Leal, A; Garcia-Mayor, R; Cordido, F; Mimic, D; Kopeschaar, H; Dieguez, C; Casanueva, F. Growth Horm. IGF Res. 1999, 9 Supl A, 101.
12. Yang, L.; Morriello, G.; Pan, Y.; Nargund, R.P.; Barakat, K.; Prendergast, K.; Cheng, K.; Chan, W.W.; Smith, R.; Patchett, A.A. Bioorg. Med. Chem. Lett., 1998, 8, 759.
13. Pihoker, C.; Middleton, R.; Reynolds, G.A.; Bowers, C.Y.; Badger, T.M. J. Clin. Endocrinol. Metab., 1995, 80, 2987.
14. Mericq, V.; Cassorla, F.; Salazar, T.; Avila, A.; Iniguez, G.; Bowers, C.Y.; Merriam, G.R. J. Clin. Endocrinol. Metab., 1998, 83, 2355.
15. Laferrere, B; Abraham, C; Rusell, CD; Bowers, CY. J. Clin. Endocrinol. Metab., 2005, 2, 611.
16. Deghenghi, R.; Cananzi, M.M.; Torsello, A.; Battisti, C.; Muller, E.E.; Locatelli, V. Life Sci., 1994, 54, 1321.
17. Deghenghi, R. In Impervious peptides as GH secretagogues. Ghigo E, Boghem M, Casanueva FF, Dieguez C, Eds. Elsevier Science BV: Amsterdam, 1999; pp. 19-24.
18. Guerlavais, V.; Boeglin, D.; Mousseaux, D.; Oiry, C.; Heitz, A.; Deghenghi, R.; Locatelli, V.; Torsello, A.; Ghe, C.; Catapano, F.; Muccioli, G.; Galleyrand, J.C.; Fehrentz, J.A.; Martinez, J. J. Med. Chem., 2003, 46, 1191.
19. Broglio, F.; Boutignon, F.; Benso, A.; Gottero, C.; Prodam, F.; Arvat, E.; Ghe, C.; Catapano, F.; Torsello, A.; Locatelli, V.; Muccioli, G.; Boeglin, D.; Guerlavais, V.; Fehrentz, J.A.; Martinez, J.; Ghigo, E.; Deghenghi, R. J. Endocrinol. Invest., 2002, 25, RC26.
20. Raun, K.; Hansen, B.S.; Johansen, N.L.; Thogersen, H.; Madsen, K.; Ankersen, M.; Andersen, P.H. Eur. J. Endocrinol., 1998, 139, 552.
21. Hansen, B.S.; Raun, K.; Nielsen, K.K.; Johansen, P.B.; Hansen, T.K.; Peschke, B.; Lau, J.; Andersen, P.H.; Ankersen, M. Eur. J. Endocrinol., 1999, 141,180.
22. Svensson, J.; Monson, J.P.; Vetter, T.; Hansen, T.K.; Savine, R.; Kann, P.; Bex, M.; Reincke, M.; Hagen, C:, Beckers, A.; Ilondo, M.M.; Zdravkovic, M.; Bengtsson, B.A.; Korbonits, M.; NN703 Clinical Research Group. Clin. Endocrinol. (Oxf), 2003, 58, 572.
23. Hansen, T.K.; Schlienger, N.; Hansen, B.S.; Andersen, P.H.; Bryce, M.R. Tetrahedron Lett., 1999, 40, 3651.
24. Hansen, T.K.; Ankersen, M.; Raun, K.; Hansen, B.S. Bioorg. Med. Chem. Lett., 2001, 11, 1915.
25. Peschke, B.; Ankersen, M.; Bauer, M.; Hansen, T.K.; Hansen, B.S.; Nielsen, K.K.; Raun, K.; Richter, L.; Westergaard, L. Eur. J. Med. Chem., 2002, 37, 487.
26. Ankersen, M.; Nielsen, K. K.; Hansen T. K.; Raun, K.; Hansen, B.S. Eur. J. Med. Chem., 2000, 35, 487.
27. Fehrentz, J.A.; Martinez, J.; Boeglin, D.; Guerlavais, V.; Deghenghi, R. Idrugs, 2002, 5, 804.
28. DeVita, R.J.; Bochis, R.; Frontier, A.J.; Kotliar, A:, Fisher, M.H.; Schoen, W.R, Wyvratt, M.J.; Cheng, K.; Chan, W.W.; Butler, B.; Jacks, T.M.; Hickey, G.J.; Schleim, K.D.; Leung, K.; Chen, Z.; Chiu, S.L.; Feeney, W.P.; Cunningham, P.K.; Smith, R.G. J. Med. Chem., 1998, 41, 1716.
29. Ye, Z.; Gao, Y.; Bakshi, R.K.; Chen, M.H.; Rohrer, S.P.; Feighner, S.D.; Pong, S.S.; Howard, A.D.; Blake, A.; Birzin, E.T.; Locco, L.; Parmar, R.M.; Chan, W.W.; Schaeffer, J.M.; Smith, R.G.; Patchett, A.A.; Nargund, R.P. Bioorg. Med. Chem. Lett., 2000, 10, 5.
30. Smith, R.G.; Cheng, K.; Schoen, W.R.; Pong, S.S.; Hickey, G.; Jacks, T.; Butler, B.; Chan, W.W.; Chaung, L.Y.; Judith, F. Science, 1993, 260, 1640.
31. Patchett, A.A.; Nargund, R.P.; Tata, J.R.; Chen, M.H.; Barakat, K.J.; Johnston, D.B.; Cheng, K.; Chan, W.W.; Butler, B.; Hickey, G. Proc. Natl. Acad. Sci., 1995, 92, 7001.
32. Yang, L.; Morriello, G.; Patchett, A.A.; Leung, K.; Jacks, T.; Cheng, K.; Schleim, K.D.; Feeney, W.; Chan, W.W.; Chiu, S.H.; Smith, R.G. J. Med. Chem., 1998, 41, 2439.
33. Barakat, K.J.; Cheng, K.; Chan, W.W.; Butler, B.S.; Jacks, T.M.; Schleim, K.D.; Hora, D.F. Jr.; Hickey, G.J.; Smith, R.G.; Patchett, A.A.; Nargund, R.P. Bioorg. Med. Chem. Lett., 1998, 8, 1431.
34. Palucki, B.L.; Feighner, S.D.; Pong, S.; McKee, K.K.; Hreniuk, D.L.; Tan, C.; Howard, A.D.; Van der Ploeg, L.H.; Patchett, A.A.; Nargund, R.P. Bioorg. Med. Chem. Lett., 2001, 11, 1955.
35. Nargund, R.P.; Barakat, K.H.; Cheng, K.; Chan, W.; Butler, B.R.; Smith, R.G.; Patchett, A.A. Bioorg. Med. Chem. Lett., 1996, 6, 1265.
36. Tokunaga, T.; Hume, W.E.; Umezome, T.; Okazaki, K.; Ueki, Y.; Kumagai, K.; Hourai, S.; Nagamine, J.; Seki, H.; Taiji, M.; Noguchi, H.; Nagata, R. J. Med. Chem., 2001, 44, 4641.
37. Nagamine, J.; Nagata, R.; Seki, H.; Nomura-Akimaru, N.; Ueki, Y.; Kumagai, K.; Taiji, M.; Noguchi, H. J. Endocrinol., 2001, 171, 481.