The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency

European Journal of Medicinal Chemistry

Volumn 37, Issue 6, 2002, Pages 487-501

  Peschke, Bernd ^a   Ankersen, Michael ^a   Bauer, Michael ^a   Hansen, Thomas Kruse ^a   Hansen, Birgit Sehested ^a   Nielsen, Karin Kramer ^a   Raun, Kirsten ^a   Richter, Lutz ^a   Westergaard, Lisbet ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

GH release; Growth hormone secretagogue; NN703; Oral bioavailability; Peptidomimetic

Indexed keywords

AMINE; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE; IPAMORELIN; TABIMORELIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; GROWTH HORMONE RELEASE; HORMONE DETERMINATION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR SIZE; NONHUMAN; RAT; SUBSTITUTION REACTION; SWINE;

ANIMALS; BIOLOGICAL AVAILABILITY; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALF-LIFE; HORMONES; HUMAN GROWTH HORMONE; HYDROGEN BONDING; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METHYLATION; MOLECULAR CONFORMATION; OLIGOPEPTIDES; RATS; SWINE;

EID: 0036592421     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01370-3     Document Type: Article

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