EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

Journal of Endocrinological Investigation

Volumn 25, Issue 8, 2002, Pages RC26-RC28

  Broglio, F ^a   Boutignon, F ^b   Benso, A ^a   Gottero, C ^a   Prodam, F ^a   Arvat, E ^a   Ghe C ^c   Catapano, F ^c   Torsello, A ^d   Locatelli, V ^d   Muccioli, G ^c   Boeglin, D ^e   Guerlavais, V ^e   Fehrentz, J A ^e   Martinez, J ^e   Ghigo, Ezio ^a   Deghenghi, R ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b Ardana   (France)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

^e Laboratoire des Aminoacides   (France)

Author keywords

GH; Ghrelin receptors; Humans; Oral administration; Synthetic GH secretagogues

Indexed keywords

2 METHYLALANYL DEXTRO TRYPTOPHAN 1 FORMAMIDO 2 (3 INDOLYL)ETHYLAMIDE; AMINOISOBUTYRYL DEXTRO TRYPTOPHYL DGTRYPTOPHYL ALDEHYDE; CORTICOTROPIN; FOLLITROPIN; GHRELIN; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE SECRETAGOGUE; HEXARELIN; PLACEBO; PROLACTIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BLOOD SAMPLING; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; FOLLITROPIN BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONE DETERMINATION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPOPHYSIS; HYPOTHALAMUS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NEWBORN; NONHUMAN; NORMAL HUMAN; PROLACTIN BLOOD LEVEL; RAT; REPRODUCIBILITY; SIDE EFFECT;

ADULT; ANIMALS; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; MALE; OLIGOPEPTIDES; PEPTIDE HORMONES; PITUITARY GLAND; RATS;

EID: 0036733916     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345096     Document Type: Article

References (9)

1. Ghrelin: Discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
2. Peptidomimetic regulation of growth hormone secretion
3. Neuroendocrine and peripheral activities of ghrelin: Implications in metabolism and obesity
4. Purification and distribution of ghrelin: The natural endogenous ligand for the growth hormone secretagogue receptor
5. Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland
6. 125I-labelled ghrelin to membranes from human hypothalamus and pituitary gland
7. Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release
8. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: Comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone