Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 11, 1998, Pages 1431-1436

  Barakat, Khaled J ^a   Cheng, Kang ^a   Chan, Wanda W S ^a   Butler, Bridget S ^a   Jacks, Thomas M ^a   Schleim, Klaus D ^a   Hora Jr , Donald F ^a   Hickey, Gerard J ^a   Smith, Roy G ^a   Patchett, Arthur A ^a   Nargund, Ravi P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE DERIVATIVE; PHENYLPIPERAZINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CELLS, CULTURED; DRUG DESIGN; GROWTH HORMONE; INDOLES; MOLECULAR MIMICRY; PEPTIDES; PIPERAZINES; PITUITARY GLAND; RATS; SPIRO COMPOUNDS; STIMULATION, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0032474520     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00238-8     Document Type: Article

References (11)

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10. 50 for half-maximal release of GH in the rat pituitary cell assay normalized for L-692,429 @ 60 nM.
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